Startseite Association of hepatokines with markers of endothelial dysfunction and vascular reactivity in obese adolescents
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Association of hepatokines with markers of endothelial dysfunction and vascular reactivity in obese adolescents

  • David Stein , Daniela Ovadia , Stuart Katz und Preneet Cheema Brar ORCID logo EMAIL logo
Veröffentlicht/Copyright: 26. Februar 2024
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 37 Heft 4

Abstract

Objectives

Obesity-induced insulin resistance (IR) is known to influence hepatic cytokines (hepatokines), including fibroblast growth factor (FGF-21), fetuin-A, and chemerin. This study aimed to investigate the association between hepatokines and markers of endothelial dysfunction and vascular reactivity in obese adolescents.

Methods

A total of 45 obese adolescents were categorized into three groups based on glucose tolerance: normal glucose tolerance (NGT), prediabetes (PD), and type 2 diabetes (T2D). We examined the relationships between FGF-21, fetuin-A, and chemerin with endothelial markers (plasminogen activator inhibitor-1 [PAI-1], intercellular adhesion molecule-1 [ICAM-1], and vascular cell adhesion marker-1 [VCAM-1]) and vascular surrogates (brachial artery reactivity testing [BART] and peak reactive hyperemia [PRH]).

Results

Obese adolescents (age 16.2±1.2 years; 62 % female, 65 % Hispanic) with NGT (n=20), PD (n=14), and T2D (n=11) had significant differences between groups in BMI; waist-hip ratio (p=0.05), systolic BP (p=0.008), LDL-C (p=0.02), PAI-1 (p<0.001). FGF-21 pg/mL (mean±SD: NGT vs. PD vs. T2D 54±42; 266±286; 160±126 p=0.006) and fetuin-A ng/mL (266±80; 253±66; 313±50 p=0.018), were significantly different while chemerin ng/mL (26±5; 31±10; 28±2) did not significantly differ between the groups. Positive correlations were found between chemerin and both PAI-1 (r=0.6; p=0.05) and ICAM-1 (r=0.6; p=0.05), FGF-21 and PAI-1 (r=0.6; p<0.001), and fetuin-A with TNFα (r=−0.4; p=0.05). Negative correlations were found between chemerin and PRH (r= −0.5; p=0.017) and fetuin-A and PRH (r=−0.4; p=0.05).

Conclusions

In our cohort, IR predicted higher FGF-21 levels suggesting a linear relationship may exist between the two parameters. Hepatokines can augment alterations in the microvascular milieu in obese adolescents as demonstrated by their associations with the markers PAI-1, ICAM-1, and PRH.

Keywords: fibroblast growth factor 21 (FGF-21); chemerin; fetuin-A; endothelial dysfunction; adolescent obesity; diabetes mellitus
Corresponding author: Preneet Cheema Brar, MD, MS, Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, New York University Grossman School of Medicine, 153 East 32nd Street, L3, New York, NY, 10016, USA, Phone: 212-263-5940, Fax: 646-363-7754, E-mail:

  1. Research ethics: The study received approval from the New York University Institutional Review Board.

  2. Informed consent: Informed consent was obtained from all individuals included in this study.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: Authors state no conflict of interest.

  5. Research funding: None declared.

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Received: 2023-07-20
Accepted: 2024-02-05
Published Online: 2024-02-26
Published in Print: 2024-04-25

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. The effect of GnRH analog treatment on BMI in children treated for precocious puberty: a systematic review and meta-analysis
  4. Original Articles
  5. Association of hepatokines with markers of endothelial dysfunction and vascular reactivity in obese adolescents
  6. Evaluation of cardiac electrophysiological features in patients with premature adrenarche
  7. Growth hormone treatment in children with short stature: impact of the diagnosis on parents
  8. Ovarian reserve and fertility parameters in post-pubertal females with congenital adrenal hyperplasia: a case-control study
  9. Early change of retinal nerve fiber layer in children with type 1 diabetes mellitus in northern China
  10. Investigating the connection among thyroid function, sensitivity to thyroid hormones, and metabolic syndrome in euthyroid children and adolescents affected by type 1 diabetes
  11. Surgical treatment of secondary hyperparathyroidism in children with chronic kidney disease. Experience in 19 patients
  12. Short Communication
  13. Decline in case rates of youth onset type 2 diabetes in year three of the COVID-19 pandemic
  14. Letters to the Editor
  15. The effect of phenylketonuria on family quality of life
  16. Struggle for the future health of adolescent patients with phenylketonuria and parents with a sick child due to the economic crisis
  17. Case Reports
  18. A new onset drug induced diabetes mellitus presenting with diabetic ketoacidosis in a child undergoing treatment for B cell acute lymphoblastic leukemia. A case report and review of literature
  19. Late diagnosis of the X-linked MCT8 deficiency (Allan–Herndon–Dudley syndrome) in a teenage girl with primary ovarian insufficiency
  20. An infant developing hypercalcemia and hypophosphatemia due to the use of exclusively almond milk
  21. New data supporting that early diagnosis and treatment are possible and necessary in intracellular cobalamin depletion: the case of transcobalamin II deficiency
https://doi.org/10.1515/jpem-2023-0339
Schlagwörter für diesen Artikel
fibroblast growth factor 21 (FGF-21); chemerin; fetuin-A; endothelial dysfunction; adolescent obesity; diabetes mellitus

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. The effect of GnRH analog treatment on BMI in children treated for precocious puberty: a systematic review and meta-analysis
  4. Original Articles
  5. Association of hepatokines with markers of endothelial dysfunction and vascular reactivity in obese adolescents
  6. Evaluation of cardiac electrophysiological features in patients with premature adrenarche
  7. Growth hormone treatment in children with short stature: impact of the diagnosis on parents
  8. Ovarian reserve and fertility parameters in post-pubertal females with congenital adrenal hyperplasia: a case-control study
  9. Early change of retinal nerve fiber layer in children with type 1 diabetes mellitus in northern China
  10. Investigating the connection among thyroid function, sensitivity to thyroid hormones, and metabolic syndrome in euthyroid children and adolescents affected by type 1 diabetes
  11. Surgical treatment of secondary hyperparathyroidism in children with chronic kidney disease. Experience in 19 patients
  12. Short Communication
  13. Decline in case rates of youth onset type 2 diabetes in year three of the COVID-19 pandemic
  14. Letters to the Editor
  15. The effect of phenylketonuria on family quality of life
  16. Struggle for the future health of adolescent patients with phenylketonuria and parents with a sick child due to the economic crisis
  17. Case Reports
  18. A new onset drug induced diabetes mellitus presenting with diabetic ketoacidosis in a child undergoing treatment for B cell acute lymphoblastic leukemia. A case report and review of literature
  19. Late diagnosis of the X-linked MCT8 deficiency (Allan–Herndon–Dudley syndrome) in a teenage girl with primary ovarian insufficiency
  20. An infant developing hypercalcemia and hypophosphatemia due to the use of exclusively almond milk
  21. New data supporting that early diagnosis and treatment are possible and necessary in intracellular cobalamin depletion: the case of transcobalamin II deficiency
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