Associated autoimmune thyroid diseases in children and adolescents with type one diabetes in Jordan
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Rasha Odeh
,
Lobna Gharaibeh
,
Sarah Ibrahim
and
Abeer Alassaf
Abstract
Objectives
To investigate the prevalence of thyroid autoimmunity and related thyroid disorders among children and adolescents with type 1 diabetes in Jordan.
Methods
In a retrospective study, thyroid stimulating hormone and thyroid hormone (Free T4) levels were measured in 684 children with type 1 diabetes who presented to Jordan University Hospital between January 2012 and February 2021. Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TGAb) antibodies were measured in 526 and 438 subjects with type 1 diabetes, respectively.
Results
681 children were included in the study (52.4 % females, average current age 14.3 years, average age at diagnosis 8.0 years, and average diabetes duration 6.2 years). Of the whole group, 18 children (2.6 %) were diagnosed with subclinical hypothyroidism and 31 children (4.4 %) had overt hypothyroidism. Of those who were tested for TPOAb and TGAb, 22.6 and 23.1 % were positive respectively. Predictors for developing hypothyroidism were female sex and positive antibodies to glutamic acid decarboxylase.
Conclusions
Screening for associated thyroid autoimmunity in children and adolescents with type one diabetes from Jordan is advised with a special focus on females and those with positive antibodies to glutamic acid decarboxylase.
Funding source: Deanship of Academic Research, University of Jordan
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Research ethics: The study was approved by the Institutional Ethics Committee of Jordan University Hospital, Amman, Jordan. (approval no. 11702/2023).The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).
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Informed consent: Not applicable.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Research funding: This research has been done during the sabbatical leave for the first author from the University of Jordan for the academic year 2021/2022.
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Data availability: The raw data can be obtained on request from the corresponding author.
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© 2023 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- Artificial Intelligence (AI) in pediatric endocrinology
- Relationship between vitamin D deficiency and neonatal hypocalcemia: a meta-analysis
- Original Articles
- Associated autoimmune thyroid diseases in children and adolescents with type one diabetes in Jordan
- The therapeutic effect of oral desmopressin lyophilisate formulation in children with central diabetes insipidus
- Effect of complete suppression of androstenedione on auxological development in prepubertal patients with classical congenital adrenal hyperplasia
- Safety and efficacy of the structured onboarding steps and initiation protocol for MiniMed™ 780G system among an Egyptian cohort of young people living with type 1 diabetes
- The effect of problem-solving skills on blood glucose regulation and disease management in children with type 1 diabetes mellitus
- Depression, anxiety, eating problems, and diabulimia risk in adolescents with type 1 diabetes: a case–control study
- Genotyping in patients with congenital adrenal hyperplasia by sequencing of newborn bloodspot samples
- Case Reports
- A pediatric case of autosomal dominant hypocalcemia type 2
- Very severe hypertriglyceridemia complicating pediatric acute lymphoblastic leukemia treatment: a call for management guidelines
- Management of acute metabolic crisis in TANGO2 deficiency: a case report
- Novel PAX4 variant in a child and family with diabetes mellitus – case report and review of the literature
- Graves’ disease after COVID mRNA vaccination for the first time diagnosed in adolescence-case report. Cause and effect relationship or simple coincidence?
Articles in the same Issue
- Frontmatter
- Reviews
- Artificial Intelligence (AI) in pediatric endocrinology
- Relationship between vitamin D deficiency and neonatal hypocalcemia: a meta-analysis
- Original Articles
- Associated autoimmune thyroid diseases in children and adolescents with type one diabetes in Jordan
- The therapeutic effect of oral desmopressin lyophilisate formulation in children with central diabetes insipidus
- Effect of complete suppression of androstenedione on auxological development in prepubertal patients with classical congenital adrenal hyperplasia
- Safety and efficacy of the structured onboarding steps and initiation protocol for MiniMed™ 780G system among an Egyptian cohort of young people living with type 1 diabetes
- The effect of problem-solving skills on blood glucose regulation and disease management in children with type 1 diabetes mellitus
- Depression, anxiety, eating problems, and diabulimia risk in adolescents with type 1 diabetes: a case–control study
- Genotyping in patients with congenital adrenal hyperplasia by sequencing of newborn bloodspot samples
- Case Reports
- A pediatric case of autosomal dominant hypocalcemia type 2
- Very severe hypertriglyceridemia complicating pediatric acute lymphoblastic leukemia treatment: a call for management guidelines
- Management of acute metabolic crisis in TANGO2 deficiency: a case report
- Novel PAX4 variant in a child and family with diabetes mellitus – case report and review of the literature
- Graves’ disease after COVID mRNA vaccination for the first time diagnosed in adolescence-case report. Cause and effect relationship or simple coincidence?
