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Relationship between vitamin D deficiency and neonatal hypocalcemia: a meta-analysis

  • Ruihan Li , Aojing Han , Qilin Hu and Wei Liang EMAIL logo
Published/Copyright: August 28, 2023
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 36 Issue 10

Abstract

We aimed to explore the associations of neonatal hypocalcemia with neonatal vitamin D deficiency and maternal vitamin D deficiency. A comprehensive systematic literature search using PubMed and web of science was performed for relevant articles from inception to February 17th, 2023. We used odds ratio (OR) and 95 % confidence interval (CI) as effect sizes for our meta-analysis. Publication bias was evaluated using funnel plot, Begg’s test, and Egger regression test. All the statistical analyses were performed using Stata 14.0. A total of 11 studies were included and analyzed, including 452 newborns with hypocalcemia and 2,599 newborns with normal serum calcium level. Our research results revealed that vitamin D deficiency in newborns may be related to the higher prevalence of hypocalcemia (OR: 2.87, 95 % CI: 1.17–7.04). In addition, maternal vitamin D deficiency might also be a risk factor for neonatal hypocalcemia (OR: 7.83, 95 % CI: 3.62–16.92). There was a significant correlation between vitamin D deficiency and neonatal hypocalcemia.This meta-analysis indicates that newborns with vitamin D deficiency have a higher risk of hypocalcemia, and maternal vitamin D level play a crucial role in this association. Vitamin D supplementation may have a positive effect in reducing the prevalence of neonatal hypocalcemia.

Keywords: vitamin D; hypocalcemia; meta-analysis; newborns
Corresponding author: Wei Liang, School of Public Health, Wuhan University, Wuhan, 430071, P.R. China, Phone: +86 18136791029, E-mail:

Acknowledgments

Thanks to Hou Dong from Zhenjiang Center for Disease Control and Prevention for the help with grammar.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  4. Competing interests: The authors state no conflict of interest.

  5. Research funding: None declared.

  6. Data availability: The raw data can be obtained on request from the corresponding author.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/jpem-2023-0183).

Received: 2023-04-25
Accepted: 2023-08-15
Published Online: 2023-08-28
Published in Print: 2023-10-26

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

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  4. Relationship between vitamin D deficiency and neonatal hypocalcemia: a meta-analysis
  5. Original Articles
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https://doi.org/10.1515/jpem-2023-0183
Keywords for this article
vitamin D; hypocalcemia; meta-analysis; newborns

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Artificial Intelligence (AI) in pediatric endocrinology
  4. Relationship between vitamin D deficiency and neonatal hypocalcemia: a meta-analysis
  5. Original Articles
  6. Associated autoimmune thyroid diseases in children and adolescents with type one diabetes in Jordan
  7. The therapeutic effect of oral desmopressin lyophilisate formulation in children with central diabetes insipidus
  8. Effect of complete suppression of androstenedione on auxological development in prepubertal patients with classical congenital adrenal hyperplasia
  9. Safety and efficacy of the structured onboarding steps and initiation protocol for MiniMed™ 780G system among an Egyptian cohort of young people living with type 1 diabetes
  10. The effect of problem-solving skills on blood glucose regulation and disease management in children with type 1 diabetes mellitus
  11. Depression, anxiety, eating problems, and diabulimia risk in adolescents with type 1 diabetes: a case–control study
  12. Genotyping in patients with congenital adrenal hyperplasia by sequencing of newborn bloodspot samples
  13. Case Reports
  14. A pediatric case of autosomal dominant hypocalcemia type 2
  15. Very severe hypertriglyceridemia complicating pediatric acute lymphoblastic leukemia treatment: a call for management guidelines
  16. Management of acute metabolic crisis in TANGO2 deficiency: a case report
  17. Novel PAX4 variant in a child and family with diabetes mellitus – case report and review of the literature
  18. Graves’ disease after COVID mRNA vaccination for the first time diagnosed in adolescence-case report. Cause and effect relationship or simple coincidence?
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