Daily vs. monthly oral vitamin D3 for treatment of symptomatic vitamin D deficiency in infants: a randomized controlled trial
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Anupriya Gora
Abstract
Objectives
Compare the efficacy and safety of daily vs. monthly oral vitamin D3 in treating symptomatic vitamin D deficiency in infants.
Methods
90 infants with symptomatic vitamin D deficiency were randomized into Daily (D) [46 infants] and Bolus (B) [44 infants] groups to receive oral vitamin D3, daily (2000 IU/day) and bolus (60,000 IU/month) for three months respectively. Both groups received daily oral calcium @50 mg/kg/day. Serum calcium (Ca), phosphate (P), alkaline phosphatase (ALP), 25-hydroxy cholecalciferol [25(OH)D], parathyroid hormone (PTH) levels, urine calcium: creatinine ratio and radiological score were assessed at baseline, 4 and 12 weeks. At the end of 12 weeks, 78 infants were available for evaluation of efficacy and safety of both regimens.
Results
Both regimens led to a statistically significant increase in Ca and P levels and fall in ALP and PTH levels from baseline to 4 and 12 weeks of therapy, with no inter-group difference. Infants in group D had statistically significant higher mean 25(OH)D levels as compared to group B at 4 weeks (group D 130.89 ± 43.43 nmol/L, group B – 108.25 ± 32.40 nmol/L; p – 0.012) and 12 weeks (group D – 193.69 ± 32.47 nmol/L, group B – 153.85 ± 33.60 nmol/L; p<0.001). Eight infants [group D – 6/41 (14.6 %); group B – 2/37 (5.4 %), p=0.268] developed mild asymptomatic hypercalcemia without hypercalciuria at 12 weeks that corrected spontaneously within a week.
Conclusions
Both daily and monthly oral vitamin D3 in equivalent doses are efficacious and safe for treating symptomatic vitamin D deficiency in infants.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: Cleared by the Institutional Ethics Committee, Lady Hardinge Medical College (LHMC/ECHR/2018/63 T) on 26/10/2018.
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© 2023 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review Article
- Molecular mechanisms involved in fetal programming and disease origin in adulthood
- Original Articles
- Neuropathy in paediatric type 1 diabetes mellitus – clinical characterization and analysis of risk factors in the diabetes prospective follow-up registry DPV (Diabetes-Patienten-Verlaufsdokumentation)-registry
- Effect of metabolic control on cognitive functions in children and adolescents with type 1 diabetes mellitus
- Uric acid and sCD163 as biomarkers for metabolic dysfunction and MAFLD in children and adolescents with overweight and obesity
- Endocrinological, immunological and metabolic features of patients with Fabry disease under therapy
- Evaluation and management of pediatric thyroid nodules and thyroid cancer at a single institution after adoption of the American Thyroid Association 2015 guidelines
- Fasting ketone levels vary by age: implications for differentiating physiologic from pathologic ketotic hypoglycemia
- Association of adipocytokines and adipocytokine ratios with cardiovascular risk factors in Japanese preadolescents
- Daily vs. monthly oral vitamin D3 for treatment of symptomatic vitamin D deficiency in infants: a randomized controlled trial
- Short Communication
- Management and outcomes in secondary diabetes among pediatric patients hospitalized with hemophagocytic lymphohistiocytosis
- Letter to the Editor
- Potential usefulness of assessing serum betamethasone levels during betamethasone therapy
- Case Reports
- Acquired idiopathic isolated ACTH deficiency with associated autoimmune thyroiditis in pediatrics: case report and review of the literature
- A very rare cause of hypertrygliseridemia in infancy: a novel mutation in glycerol-3-phosphate dehydrogenase 1 (GPD1) gene
- Difficult to think about but easy to treat: scurvy
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- Corrigendum
- Diagnosis of adrenal insufficiency in children: a survey among pediatric endocrinologists in North America
Artikel in diesem Heft
- Frontmatter
- Review Article
- Molecular mechanisms involved in fetal programming and disease origin in adulthood
- Original Articles
- Neuropathy in paediatric type 1 diabetes mellitus – clinical characterization and analysis of risk factors in the diabetes prospective follow-up registry DPV (Diabetes-Patienten-Verlaufsdokumentation)-registry
- Effect of metabolic control on cognitive functions in children and adolescents with type 1 diabetes mellitus
- Uric acid and sCD163 as biomarkers for metabolic dysfunction and MAFLD in children and adolescents with overweight and obesity
- Endocrinological, immunological and metabolic features of patients with Fabry disease under therapy
- Evaluation and management of pediatric thyroid nodules and thyroid cancer at a single institution after adoption of the American Thyroid Association 2015 guidelines
- Fasting ketone levels vary by age: implications for differentiating physiologic from pathologic ketotic hypoglycemia
- Association of adipocytokines and adipocytokine ratios with cardiovascular risk factors in Japanese preadolescents
- Daily vs. monthly oral vitamin D3 for treatment of symptomatic vitamin D deficiency in infants: a randomized controlled trial
- Short Communication
- Management and outcomes in secondary diabetes among pediatric patients hospitalized with hemophagocytic lymphohistiocytosis
- Letter to the Editor
- Potential usefulness of assessing serum betamethasone levels during betamethasone therapy
- Case Reports
- Acquired idiopathic isolated ACTH deficiency with associated autoimmune thyroiditis in pediatrics: case report and review of the literature
- A very rare cause of hypertrygliseridemia in infancy: a novel mutation in glycerol-3-phosphate dehydrogenase 1 (GPD1) gene
- Difficult to think about but easy to treat: scurvy
- Severe hypophosphataemia can be an early sign of osteopetrorickets: a case report
- Corrigendum
- Diagnosis of adrenal insufficiency in children: a survey among pediatric endocrinologists in North America
