The association between plasma carnitines and duration of diabetic ketoacidosis treatment in children with type 1 diabetes
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Deniz Okdemir
Abstract
Objectives
The aim of this study is to determine the plasma free carnitine and acyl-carnitine levels at the time of diabetic ketoacidosis (DKA) diagnosis, and at the end of DKA treatment and to investigate their association with the duration of DKA treatment in children with DKA.
Methods
A total of 40 children with DKA who were treated consecutively in a tertiary health center for DKA were included in the study. The median age of the children was 11.3 years (1.1–17.5) and 25 of them (62.5%) were girls. In addition to routine blood tests, plasma free carnitine and acyl-carnitine levels were measured just before the start of intravenous insulin therapy and at the time of discontinuation of intravenous insulin therapy when DKA therapy was completed.
Results
There was no difference in plasma free carnitine and acyl-carnitine levels before and after DKA treatment (p=0.776 and p=0.743 respectively). However, while the frequency of low plasma free carnitine was 30% at the beginning of the treatment, it was observed that this frequency was 20% at the end of the DKA treatment. There was no correlation between duration of DKA treatment and plasma free carnitine or acyl-carnitine levels at admission (p=0.497, r=−0.111 and p=0.474, r=0.116 respectively).
Conclusions
There is no a relationship between duration of DKA treatment and plasma free carnitine or acyl-carnitine level at admission in children with DKA.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from the legal guardians of all individuals included in this study.
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Ethical approval: Ethical approval for the study was obtained from the local Ethics Committee.
References
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review Article
- The efficacy and safety of dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 agonists in pediatric patients with type 2 diabetes: a systematic review
- Original Articles
- Triple burden of malnutrition and role of anaemia in the development of complications associated with type 1 diabetes in Indian children and youth
- Effect of obesity and excessive body fat on glycaemic control in paediatric type 1 diabetes
- Role of pan immune inflammatory value in the evaluation of hepatosteatosis in children and adolescents with obesity
- Secular trends of birth weight and its associations with obesity and hypertension among Southern Chinese children and adolescents
- Insights into the implication of obesity in hypogonadism among adolescent boys
- The association between plasma carnitines and duration of diabetic ketoacidosis treatment in children with type 1 diabetes
- Cathelicidin as a marker for subclinical cardiac changes and microvascular complications in children and adolescents with type 1 diabetes
- Developing a risk assessment tool for identifying individuals at high risk for developing insulin resistance in European adolescents: the HELENA-IR score
- Hemoglobin A1C can differentiate subjects with GCK mutations among patients suspected to have MODY
- Perceptions and use of complementary and alternative medicine in patients with precocious puberty
- Case Reports
- Infection with SARS-CoV-2 may alter the half-life of desmopressin (DDAVP) in patients with central diabetes insipidus
- Heterozygous CDC73 mutation causing hyperparathyroidism in children and adolescents: a report of 2 cases
- Wolfram syndrome in a young woman with associated hypergonadotropic hypogonadism – A case report
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Artikel in diesem Heft
- Frontmatter
- Review Article
- The efficacy and safety of dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 agonists in pediatric patients with type 2 diabetes: a systematic review
- Original Articles
- Triple burden of malnutrition and role of anaemia in the development of complications associated with type 1 diabetes in Indian children and youth
- Effect of obesity and excessive body fat on glycaemic control in paediatric type 1 diabetes
- Role of pan immune inflammatory value in the evaluation of hepatosteatosis in children and adolescents with obesity
- Secular trends of birth weight and its associations with obesity and hypertension among Southern Chinese children and adolescents
- Insights into the implication of obesity in hypogonadism among adolescent boys
- The association between plasma carnitines and duration of diabetic ketoacidosis treatment in children with type 1 diabetes
- Cathelicidin as a marker for subclinical cardiac changes and microvascular complications in children and adolescents with type 1 diabetes
- Developing a risk assessment tool for identifying individuals at high risk for developing insulin resistance in European adolescents: the HELENA-IR score
- Hemoglobin A1C can differentiate subjects with GCK mutations among patients suspected to have MODY
- Perceptions and use of complementary and alternative medicine in patients with precocious puberty
- Case Reports
- Infection with SARS-CoV-2 may alter the half-life of desmopressin (DDAVP) in patients with central diabetes insipidus
- Heterozygous CDC73 mutation causing hyperparathyroidism in children and adolescents: a report of 2 cases
- Wolfram syndrome in a young woman with associated hypergonadotropic hypogonadism – A case report
- Continuous glucose monitoring in an infant with panhypopituitarism having hypoglycemia on growth hormone therapy
- Severe consumptive hypothyroidism in hepatic hemangioendothelioma
- Efficacy of aromatase inhibitor therapy in a case with large cell calcifying Sertoli cell tumour-associated prepubertal gynaecomastia
