Startseite Medizin Standard and high dose ergocalciferol regimens for treatment of hypovitaminosis D in epileptic children and adolescents
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Standard and high dose ergocalciferol regimens for treatment of hypovitaminosis D in epileptic children and adolescents

  • Suchavadee Vichutavate , Piradee Suwanpakdee , Napakjira Likasitthananon , Nawaporn Numbenjapon , Charcrin Nabangchang und Voraluck Phatarakijnirund ORCID logo EMAIL logo
Veröffentlicht/Copyright: 4. Oktober 2022
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 35 Heft 11

Abstract

Objectives

Children with epilepsy are at increased risk of vitamin D deficiency. We aimed to compare the effect of two ergocalciferol regimens given for 90 days.

Methods

Epileptic patients aged 5–18 years who received at least one antiepileptic drug (AED) for more than 6 months and had serum 25-OHD <30 ng/mL were randomized to receive 20,000 IU/10 d (standard dose, n=41) or 60,000 IU/10 d (high dose, n=41) of oral ergocalciferol. Serum Ca, P, Mg, ALP, iPTH and urine Ca/Cr ratio were measured at baseline and after 90 days of treatment. Change in serum 25-OHD and vitamin D status after treatment was evaluated.

Results

The initial serum 25-OHD in the standard dose and high dose group was 19.5 ± 4.9 and 18.4 ± 4.6 ng/mL, respectively. Serum 25-OHD after treatment was significantly higher in the high dose group (39.0 ± 11.5 vs. 27.5 ± 8.6 ng/mL, p<0.05). The average increase in serum 25-OHD in the high dose and standard dose group was 20.6 ± 11.4 and 7.2 ± 7.5 ng/mL, respectively (p<0.05). Normalized serum 25-OHD was achieved in 80.5% of the high dose group compared to 36.6% of the standard dose group (p<0.05). No adverse events were found. Patients with a BMI Z-score>0 had a 2.5 times greater risk of continued hypovitaminosis D after treatment compared to those with a BMI Z-score<0 (95% CI: 1.0–5.9, p<0.05).

Conclusions

Oral ergocalciferol 60,000 IU/10 d for 90 days was more effective at normalizing serum 25-OHD than 20,000 IU/10 d in epileptic children and adolescents who were receiving AEDs.

Keywords: rickets; seizure children; vitamin D deficiency; vitamin D supplementation
Corresponding author: Voraluck Phatarakijnirund, MD, Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, 315 Ratchawithi Road, Phayathai, Ratchathewi, Bangkok, 10400, Thailand, Phone: +66814318155, E-mail:

Acknowledgments

We are grateful to Chula Kooanantakool for statistic consultation, Thitiwan Simasathien and Warissara Sanor for helping in this study, Professor Somchit Jarurattanasirikul for suggesting and review of manuscript.

  1. Research funding: This study was supported by a grant from Phramongkutklao College of Medicine. The funding organization played no role in the study design; in the collection analysis, and interpretation of data; in writing of the report; or in the decision to submit the report for publication.

  2. Author contributions: Suchavadee Vichutavate: performed investigation, reviewed the medical literature, analysis and interpretation of data and composed the first draft of the manuscript. Piradee Suwanpakdee, Napakjira Likasitthananon, Nawaporn Numbenjapon, Charcrin Nabangchang: helped with the clinical studies of the patients. Voraluck Phatarakijnirund: design of the work, performed and coordinated the investigation, analysis and interpretation of data, manuscript preparation and completion. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study was approved by the Institutional Review Board Royal Thai Army Medical Department.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpem-2022-0197).

Received: 2022-01-23
Accepted: 2022-09-12
Published Online: 2022-10-04
Published in Print: 2022-11-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. Effects of exercise combined with diet intervention on body composition and serum biochemical markers in adolescents with obesity: a systematic review and meta-analysis
  4. Mini Review
  5. Effect of stimulants on final adult height
  6. Original Articles
  7. Organic acidemias in the neonatal period: 30 years of experience in a referral center for inborn errors of metabolism
  8. The long-term growth, cost-effectiveness, and glycemic effects of growth hormone therapy on children born small for gestational age over 10 years: a retrospective cohort study
  9. Standard and high dose ergocalciferol regimens for treatment of hypovitaminosis D in epileptic children and adolescents
  10. Children and adolescents with type 1 diabetes mellitus in Nigeria: clinical characteristics and compliance with care
  11. Disordered eating and behaviors among young Egyptians with type 1 diabetes: risk factors and comorbidities
  12. Normal or elevated prolactin is a good indicator to show pituitary stalk interruption syndrome in patients with multiple pituitary hormone deficiency
  13. No pubertal growth spurt, rapid bone maturation, and menarche post GnRHa treatment in girls with precocious puberty
  14. Genetic analysis of failed male puberty using whole exome sequencing
  15. Gender diversity in adolescents with polycystic ovary syndrome
  16. Case Reports
  17. Management challenges of Rabson Mendenhall syndrome in a resource limited country: a case report
  18. Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha
  19. Pseudohypoaldosteronism associated with hypertrophic cardiomyopathy, hypertension and thrombocytosis due to mutation in the ELAC2 gene: a case report
  20. Acromicric dysplasia due to a novel missense mutation in the fibrillin 1 gene in a three-generation family
  21. A case of severe systemic type 1 pseudohypoaldosteronism with 10 years of evolution
  22. Advantages of monitoring rT3 and dividing LT3 dose in the treatment of consumptive hypothyroidism associated with infantile hepatic hemangioma
https://doi.org/10.1515/jpem-2022-0197
Schlagwörter für diesen Artikel
rickets; seizure children; vitamin D deficiency; vitamin D supplementation

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. Effects of exercise combined with diet intervention on body composition and serum biochemical markers in adolescents with obesity: a systematic review and meta-analysis
  4. Mini Review
  5. Effect of stimulants on final adult height
  6. Original Articles
  7. Organic acidemias in the neonatal period: 30 years of experience in a referral center for inborn errors of metabolism
  8. The long-term growth, cost-effectiveness, and glycemic effects of growth hormone therapy on children born small for gestational age over 10 years: a retrospective cohort study
  9. Standard and high dose ergocalciferol regimens for treatment of hypovitaminosis D in epileptic children and adolescents
  10. Children and adolescents with type 1 diabetes mellitus in Nigeria: clinical characteristics and compliance with care
  11. Disordered eating and behaviors among young Egyptians with type 1 diabetes: risk factors and comorbidities
  12. Normal or elevated prolactin is a good indicator to show pituitary stalk interruption syndrome in patients with multiple pituitary hormone deficiency
  13. No pubertal growth spurt, rapid bone maturation, and menarche post GnRHa treatment in girls with precocious puberty
  14. Genetic analysis of failed male puberty using whole exome sequencing
  15. Gender diversity in adolescents with polycystic ovary syndrome
  16. Case Reports
  17. Management challenges of Rabson Mendenhall syndrome in a resource limited country: a case report
  18. Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha
  19. Pseudohypoaldosteronism associated with hypertrophic cardiomyopathy, hypertension and thrombocytosis due to mutation in the ELAC2 gene: a case report
  20. Acromicric dysplasia due to a novel missense mutation in the fibrillin 1 gene in a three-generation family
  21. A case of severe systemic type 1 pseudohypoaldosteronism with 10 years of evolution
  22. Advantages of monitoring rT3 and dividing LT3 dose in the treatment of consumptive hypothyroidism associated with infantile hepatic hemangioma
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