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Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome

  • Ismail Guzelkas , Zerrin Orbak EMAIL logo , Hakan Doneray , Nurinnisa Ozturk and Nevin Sagsoz
Published/Copyright: February 16, 2022
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 35 Issue 4

Abstract

Objectives

Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction, clinical and/or biochemical hyperandrogenism, and polycystic ovaries. Its pathogenesis is still unclear. This study aimed to investigate the relationship between kisspeptin, leptin, neuropeptide Y (NPY), and neurokinin B (NKB) levels for evaluating the pathogenesis of PCOS.

Methods

Levels of these parameters were analyzed in 20 patients with PCOS, and 16 healthy adolescents.

Results

Serum NPY levels were significantly higher in the obese and non-obese PCOS group (p<0.01). There was a negative correlation between the kisspeptin and the NKB levels (p<0.01) in the PCOS group but not in the control group. This negative correlation was also found in both PCOS groups (p<0.01). In the obese PCOS group, serum kisspeptin levels were significantly lower than the control and non-obese PCOS groups (p<0.05) although serum leptin and NPY levels were significantly higher in the obese PCOS group (p<0.01).

Conclusions

The high NPY levels in both obese and non-obese patients with PCOS indicate that NPY plays a role in the pathogenesis independently from obesity. Significantly high leptin and low kisspeptin levels in the obese PCOS group suggested that they may be associated with obesity rather than PCOS.

Keywords: adolescents; kisspeptin; leptin; neuropeptide Y and neurokinin B; polycysticovary syndrome
Corresponding author: Zerrin Orbak, MD, Department of Pediatric Endocrinology, Ataturk University Faculty of Medicine, Erzurum, 25240, Turkey, Phone: 009 05333559339, E-mail:

  1. Research funding: This work was supported by Ataturk University Scientific Research Projects Commission with the code TTU-2017-6272.

  2. Author contributions: IG collected the data and drafted the initial manuscript; ZO designed the study, supervised data collection and reviewed and revised the manuscripts critically for important intellectual content; NO analyzed blood samples; HD and NS approved the final manuscript.

  3. Competing interests: The authors have no conflict of interest.

  4. Statement of Ethics: Approval for this work was obtained from the institutional Ethics Committee (B.30.2.ATA.0.01.00/109). Written informed consent form for each patient were taken.

  5. Informed consent: Informed consent was obtained from all individuals included in this study.

  6. Ethical approval: The local Institutional Review Board deemed the study exempt from review.

    Approval for this work was obtained from the institutional Ethics Committee (B.30.2.ATA.0.01.00/109).

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Received: 2021-03-14
Revised: 2022-01-26
Accepted: 2022-01-31
Published Online: 2022-02-16
Published in Print: 2022-04-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Review Article
  3. Nephrogenic diabetes insipidus: a comprehensive overview
  4. Original Articles
  5. Prevalence of type 2 diabetes mellitus, metabolic syndrome, and related morbidities in overweight and obese children
  6. Impact of sports participation on components of metabolic syndrome in adolescents: ABCD growth study
  7. Expected or unexpected clinical findings in liver glycogen storage disease type IX: distinct clinical and molecular variability
  8. Evaluation of patients with phenylalanine metabolism disorder: a single center experience
  9. The association of grandparental co-residence and dietary knowledge with excess body weight among children aged 7–15 years in China
  10. Clinical characteristics of polyglandular autoimmune syndromes in pediatric age: an observational study
  11. Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome
  12. Ultrasonographic measurements of the testicular volume in Turkish boys aged 0–8 years and comparison with international references
  13. Fructose 1,6 bisphosphatase deficiency: outcomes of patients in a single center in Turkey and identification of novel splice site and indel mutations in FBP1
  14. Benefits of metformin add-on insulin therapy (MAIT) for HbA1c and lipid profile in adolescents with type 1 diabetes mellitus: preliminary report from a double-blinded, placebo-controlled, randomized clinical trial
  15. Evaluation of efficacy and safety of long-acting PEGylated recombinant human growth hormone (Jintrolong) for patients with growth hormone deficiency
  16. Evaluation of endocrinological involvement and metabolic status in patients with Gaucher disease Type 1 and Fabry disease under enzyme replacement therapy
  17. Letter to the Editor
  18. Correspondence on “Obesity after the Covid-19 pandemic”
  19. Case Reports
  20. An unusual presentation of primary adrenal insufficiency with new onset type 1 diabetes: case report and review of the literature
  21. Niemann–Pick type C disease with a novel intronic mutation: three Turkish cases from the same family
  22. Weight management in youth with rapid-onset obesity with hypothalamic dysregulation, hypoventilation, autonomic dysregulation, and neural crest tumor (ROHHAD-NET): literature search and case report
  23. Successful use of cinacalcet monotherapy in the management of siblings with homozygous calcium-sensing receptor mutation
https://doi.org/10.1515/jpem-2021-0487
Keywords for this article
adolescents; kisspeptin; leptin; neuropeptide Y and neurokinin B; polycysticovary syndrome

Articles in the same Issue

  1. Frontmatter
  2. Review Article
  3. Nephrogenic diabetes insipidus: a comprehensive overview
  4. Original Articles
  5. Prevalence of type 2 diabetes mellitus, metabolic syndrome, and related morbidities in overweight and obese children
  6. Impact of sports participation on components of metabolic syndrome in adolescents: ABCD growth study
  7. Expected or unexpected clinical findings in liver glycogen storage disease type IX: distinct clinical and molecular variability
  8. Evaluation of patients with phenylalanine metabolism disorder: a single center experience
  9. The association of grandparental co-residence and dietary knowledge with excess body weight among children aged 7–15 years in China
  10. Clinical characteristics of polyglandular autoimmune syndromes in pediatric age: an observational study
  11. Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome
  12. Ultrasonographic measurements of the testicular volume in Turkish boys aged 0–8 years and comparison with international references
  13. Fructose 1,6 bisphosphatase deficiency: outcomes of patients in a single center in Turkey and identification of novel splice site and indel mutations in FBP1
  14. Benefits of metformin add-on insulin therapy (MAIT) for HbA1c and lipid profile in adolescents with type 1 diabetes mellitus: preliminary report from a double-blinded, placebo-controlled, randomized clinical trial
  15. Evaluation of efficacy and safety of long-acting PEGylated recombinant human growth hormone (Jintrolong) for patients with growth hormone deficiency
  16. Evaluation of endocrinological involvement and metabolic status in patients with Gaucher disease Type 1 and Fabry disease under enzyme replacement therapy
  17. Letter to the Editor
  18. Correspondence on “Obesity after the Covid-19 pandemic”
  19. Case Reports
  20. An unusual presentation of primary adrenal insufficiency with new onset type 1 diabetes: case report and review of the literature
  21. Niemann–Pick type C disease with a novel intronic mutation: three Turkish cases from the same family
  22. Weight management in youth with rapid-onset obesity with hypothalamic dysregulation, hypoventilation, autonomic dysregulation, and neural crest tumor (ROHHAD-NET): literature search and case report
  23. Successful use of cinacalcet monotherapy in the management of siblings with homozygous calcium-sensing receptor mutation
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