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The current review of adolescent obesity: the role of genetic factors

  • Birsen Yılmaz ORCID logo EMAIL logo und Makbule Gezmen Karadağ
Veröffentlicht/Copyright: 16. November 2020
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 34 Heft 2

Abstract

Obesity, a complex, multi-factor and heterogeneous condition, is thought to result from the interaction of environmental and genetic factors. Considering the result of adolescence obesity in adulthood, the role of genetic factors comes to the fore. Recently, many genome-wide association studies (GWAS) have been conducted and many loci associated with adiposity have been identified. In adolescents, the strongest association with obesity has been found in single nucleotide polymorphisms (SNP) in the FTO gene. Besides FTO, GWAS showed consistent effects between variants in MC4R, TMEM18, TNNI3K, SEC16B, GNPDA2, POMC and obesity. However, these variants may not have similar effects for all ethnic groups. Although recently genetic factors are considered to contribute to obesity, relatively little is known about the specific loci related to obesity and the mechanisms by which they cause obesity.

Keywords: adiposity; adolescent; FTO; genetic; obesity; polymorphism
Corresponding author: Birsen Yılmaz, Department of Nutrition and Dietetics, Research Assistant, Faculty of Health Sciences, Gazi University, Emek, Bişkek Cad., 6. Sok, Gazi Üniversitesi No: 2, 06490, Çankaya, Ankara, Turkey; and Department of Nutrition and Dietetics, Faculty of Health Sciences, Çukurova University, Sarıçam, Adana, Turkey, Fax: +90 (312) 216 26 36, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

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Received: 2020-08-18
Accepted: 2020-10-20
Published Online: 2020-11-16
Published in Print: 2021-02-23

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. The current review of adolescent obesity: the role of genetic factors
  4. Original Articles
  5. Trends in abdominal obesity among Chinese children and adolescents, 1993–2015
  6. Association of childhood obesity with retinal microvasculature and corneal endothelial cell morphology
  7. Communication frequency between visits is associated with improved glycemic control in pediatric diabetes
  8. Increased length of stay and hospital charges in adolescents with type 1 diabetes and psychiatric illness
  9. Distance from the endocrinology clinic and diabetes control in a rural pediatric population
  10. Care of children with type 1 diabetes mellitus in school – An interventional study
  11. Treatment and long-term follow-up of patients diagnosed with type 1 diabetes mellitus before age 5
  12. Diabetes distress in Indian children with type 1 diabetes mellitus and their mothers
  13. Impact of lockdown for COVID-19 pandemic in Indian children and youth with type 1 diabetes from different socio-economic classes
  14. First report on the nationwide prevalence of paediatric type 1 diabetes in Serbia and temporal trends of diabetes ketoacidosis at diagnosis—a multicentre study
  15. Factors affecting thyroid volume in adolescent students attending a rural middle school in East Hangzhou, China
  16. Impact of maternal thyroid disease on neonatal thyroid status
  17. Impact of growth hormone treatment on scoliosis development and progression: analysis of 1128 patients with idiopathic short stature
  18. Short Communication
  19. Are we ignoring coexisting rhabdomyolysis as an important aggravating factor for acute kidney injury among childhood diabetic ketoacidosis?
  20. Case Reports
  21. Microdeletion in the IGF-1 receptor gene of a patient with short stature and obesity: a case report
  22. SLC25A19 deficiency and bilateral striatal necrosis with polyneuropathy: a new case and review of the literature
  23. Familial neonatal nonautoimmune hyperthyroidism due to a gain-of-function (D619G) thyrotropin-receptor mutation
  24. Transient neonatal diabetes due to a disease causing novel variant in the ATP-binding cassette subfamily C member 8 (ABCC8) gene unmasks maturity-onset diabetes of the young (MODY) diabetes cases within a family
https://doi.org/10.1515/jpem-2020-0480
Schlagwörter für diesen Artikel
adiposity; adolescent; FTO; genetic; obesity; polymorphism

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. The current review of adolescent obesity: the role of genetic factors
  4. Original Articles
  5. Trends in abdominal obesity among Chinese children and adolescents, 1993–2015
  6. Association of childhood obesity with retinal microvasculature and corneal endothelial cell morphology
  7. Communication frequency between visits is associated with improved glycemic control in pediatric diabetes
  8. Increased length of stay and hospital charges in adolescents with type 1 diabetes and psychiatric illness
  9. Distance from the endocrinology clinic and diabetes control in a rural pediatric population
  10. Care of children with type 1 diabetes mellitus in school – An interventional study
  11. Treatment and long-term follow-up of patients diagnosed with type 1 diabetes mellitus before age 5
  12. Diabetes distress in Indian children with type 1 diabetes mellitus and their mothers
  13. Impact of lockdown for COVID-19 pandemic in Indian children and youth with type 1 diabetes from different socio-economic classes
  14. First report on the nationwide prevalence of paediatric type 1 diabetes in Serbia and temporal trends of diabetes ketoacidosis at diagnosis—a multicentre study
  15. Factors affecting thyroid volume in adolescent students attending a rural middle school in East Hangzhou, China
  16. Impact of maternal thyroid disease on neonatal thyroid status
  17. Impact of growth hormone treatment on scoliosis development and progression: analysis of 1128 patients with idiopathic short stature
  18. Short Communication
  19. Are we ignoring coexisting rhabdomyolysis as an important aggravating factor for acute kidney injury among childhood diabetic ketoacidosis?
  20. Case Reports
  21. Microdeletion in the IGF-1 receptor gene of a patient with short stature and obesity: a case report
  22. SLC25A19 deficiency and bilateral striatal necrosis with polyneuropathy: a new case and review of the literature
  23. Familial neonatal nonautoimmune hyperthyroidism due to a gain-of-function (D619G) thyrotropin-receptor mutation
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Heruntergeladen am 19.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/jpem-2020-0480/pdf
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