Effects of vitamin D and estrogen receptor polymorphisms on bone mineral density in adolescents with anorexia nervosa
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Işıl İnan-Erdoğan
,
Kübra Işgın-Atıcı
Abstract
Background
Anorexia nervosa (AN) is a serious eating disorder that is associated with decreased bone mineral density (BMD) and greater lifetime risk for fractures. The aim of this study was to determine the correlation between BMD and genetic polymorphisms in AN.
Methods
This case-control study analyzed vitamin D receptor (VDR) (VDRBsml, VDRFokl) and estrogen receptor (ESR) (ESR1Xbal, ESR1Pvull) polymorphisms in 45 adolescents diagnosed with AN and 46 age-matched healthy controls. BMD values of the AN group were classified as low or normal, and polymorphisms were compared between cases and controls. The effects of body mass index (BMI), duration of disease and amenorrhea on BMD were also evaluated.
Results
In girls with AN, a positive effect of the bb genotype of VDRBsmI polymorphism on femur Z-scores (p = 0.103) and of the Ff genotype of VDRFokI polymorphism on vertebra Z-scores (p = 0.097) was observed. In boys with AN, a positive effect of the Ff genotype of VDRFokI polymorphism on vertebra BMD (g/cm2) was detected (p = 0.061). No association was detected between ESR polymorphisms. An inverse relationship was observed between BMD and duration of illness and amenorrhea. A direct relationship was detected between BMD and BMI.
Conclusions
Specific VDR gene polymorphism genotypes may have positive effects on BMD in patients with AN. Additionally, the lack of association between ESR gene polymorphisms on BMD could be attributed to the low estrogen status of the patient.
Author contributions: All procedures performed in this study involving human participants were in accordance with the ethical standards of the Hacettepe University Noninvasive Clinical Researches Ethical Committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Research funding: This study was funded by Hacettepe University Scientific Research Projects Coordination Unit (grant number: THD-2015-5065).
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
Conflict of interest: All authors have no conflicts of interest.
Informed consent: Informed consent was obtained from all individual participants and the parents/LAR of participants included in the study.
References
1. Treasure J, Claudino AM, Zucker N. Eating disorders. Lancet 2010;375:583–93.10.1016/S0140-6736(09)61748-7Suche in Google Scholar PubMed
2. Lucas AR, Beard CM, O’Fallon WM, Kurland LT. 50-Year trends in the incidence of anorexia nervosa in Rochester, Minn.: a population-based study. Am J Psychiatry 1991;148:917–22.10.1176/ajp.148.7.917Suche in Google Scholar PubMed
3. Smink FR, van Hoeken D, Hoek HW. Epidemiology, course, and outcome of eating disorders. Curr Opin Psychiatry 2013;26:543–8.10.1097/YCO.0b013e328365a24fSuche in Google Scholar PubMed
4. Katzman DK. Medical complications in adolescents with anorexia nervosa: a review of the literature. Int J Eat Disord 2005;37:52–9.10.1002/eat.20118Suche in Google Scholar PubMed
5. Rosen DS. Identification and management of eating disorders in children and adolescents. Pediatrics 2010;126:1240–53.10.1542/peds.2010-2821Suche in Google Scholar PubMed
6. Misra M, Klibanski A. Anorexia nervosa and bone. J Endocrinol 2014;221:163–76.10.1530/JOE-14-0039Suche in Google Scholar PubMed PubMed Central
7. Soyka LA, Misra M, Frenchman A, Miller KK, Grinspoon S, et al. Abnormal bone mineral accrual in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 2002;87:4177–85.10.1210/jc.2001-011889Suche in Google Scholar PubMed
8. Vestergaard P, Emborg C, Støving RK, Hagen C, Mosekilde L, et al. Fractures in patients with anorexia nervosa, bulimia nervosa, and other eating disorders – a nationwide register study. Int J Eat Disord 2002;32:301–8.10.1002/eat.10101Suche in Google Scholar PubMed
9. Misra M, Golden NH, Katzman DK. State of the art systematic review of bone disease in anorexia nervosa. Int J Eat Disord 2016;49:276–92.10.1002/eat.22451Suche in Google Scholar PubMed PubMed Central
10. Fazeli PK, Klibanski A. Anorexia nervosa and bone metabolism. Bone 2014;66:39–45.10.1016/j.bone.2014.05.014Suche in Google Scholar PubMed PubMed Central
11. Campbell K, Peebles R. Eating disorders in children and adolescents: state of the art review. Pediatrics 2014;134:582–92.10.1542/peds.2014-0194Suche in Google Scholar PubMed
12. Misra M, Aggarwal A, Miller KK, Almazan C, Worley M, et al. Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls. Pediatrics 2004;114:1574–83.10.1542/peds.2004-0540Suche in Google Scholar PubMed
13. Riggs BL. The mechanisms of estrogen regulation of bone resorption. J Clin Invest 2000;106:1203–4.10.1172/JCI11468Suche in Google Scholar PubMed
14. Modder UI, Clowes JA, Hoey K, Peterson JM, McCready L, et al. Regulation of circulating sclerostin levels by sex steroids in women and in men. J Bone Miner Res 2011;26:27–34.10.1002/jbmr.128Suche in Google Scholar PubMed
15. Faje AT, Fazeli PK, Katzman D, Miller KK, Breggia A, et al. Inhibition of Pref-1 (preadipocyte factor 1) by oestradiol in adolescent girls with anorexia nervosa is associated with improvement in lumbar bone mineral density. Clin Endocrinol (Oxf) 2013;79:326–32.10.1111/cen.12144Suche in Google Scholar PubMed
16. Deng W, Han JC, Chen L, Qi WL. Estrogen receptor alpha gene PvuII polymorphism and risk of fracture in postmenopausal women: a meta-analysis. Genet Mol Res 2015;14:1293–300.10.4238/2015.February.13.8Suche in Google Scholar PubMed
17. Gennari L, Merlotti D, De Paola V, Calabrò A, Becherini L, et al. Estrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE review. Am J Epidemiol 2005;161:307–20.10.1093/aje/kwi055Suche in Google Scholar PubMed
18. Uitterlinden AG, Fang Y, Bergink AP, van Meurs JB, van Leeuwen HP, et al. The role of vitamin D receptor gene polymorphisms in bone biology. Mol Cell Endocrinol 2002;197:15–21.10.1016/S0303-7207(02)00274-5Suche in Google Scholar PubMed
19. Mohammadi Z, Fayyazbakhsh F, Ebrahimi M, Amoli MM, Khashayar P, et al. Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review. J Diabetes Metab Disord 2014;13:98.10.1186/s40200-014-0098-xSuche in Google Scholar PubMed PubMed Central
20. Ferrari S, Rizzoli R, Slosman D, Bonjour JP. Familial resemblance for bone mineral mass is expressed before puberty. J Clin Endocrinol Metab 1998;83:358–61.10.1210/jc.83.2.358Suche in Google Scholar PubMed
21. Laaksonen MM, Karkkainen MU, Outila TA, Rita HJ, Lamberg-Allardt CJ. Vitamin D receptor gene start codon polymorphism (FokI) is associated with forearm bone mineral density and calcaneal ultrasound in Finnish adolescent boys but not in girls. J Bone Miner Metab 2004;22:479–85.10.1007/s00774-004-0510-6Suche in Google Scholar PubMed
22. Stergioti E, Deligeoroglou E, Economou E, Tsitsika A, Dimopoulos KD, et al. Gene receptor polymorphism as a risk factor for BMD deterioration in adolescent girls with anorexia nervosa. Gynecol Endocrinol 2013;29:716–9.10.3109/09513590.2013.798275Suche in Google Scholar PubMed
23. American Psychiatric Association. Eating Disorders. In: Diagnostic and statistical manual of mental disorders, 5th ed. Washington, DC, USA: American Psychiatric Association (APA), 2013.Suche in Google Scholar
24. American Psychiatric Association. Eating Disorders. In: Diagnostic and statistical manual of mental disorders, 4th ed., Text Revision. Washington, DC, USA: American Psychiatric Association (APA), 2000.Suche in Google Scholar
25. “2 to 20 years: Boys-Girls. Body mass index-for-age percentiles”. Published May 30, 2000 (modified 10/16/00). Developed by the National Center for Health Statistics in collaboration with the National Center for Chronic Disease Prevention and Health Promotion. http://www.cdc.gov/growthcharts.Suche in Google Scholar
26. Bogunovic L, Doyle SM, Vogiatzi MG. Measurement of bone density in the pediatric population. Curr Opin Pediatr 2009;21:77–82.10.1097/MOP.0b013e32831ec338Suche in Google Scholar PubMed
27. Bianchi ML. Osteoporosis in children and adolescents. Bone 2007;41:486–95.10.1016/j.bone.2007.07.008Suche in Google Scholar PubMed
28. Falcini F, Bindi G, Ermini M, Galluzzi F, Poggi G, et al. Comparison of quantitative calcaneal ultrasound and dual energy X-ray absorptiometry in the evaluation of osteoporotic risk in children with chronic rheumatic diseases. Calcif Tissue Int 2000;67:19–23.10.1007/s00223001090Suche in Google Scholar PubMed
29. Sundberg SS, Sernbo I, Karlsson MK. Normative calcaneal quantitative ultrasound data as an estimation of skeletal development in Swedish children and adolescents. Calcif Tissue Int 2010;87:493–506.10.1007/s00223-010-9425-5Suche in Google Scholar PubMed
30. Wünsche K, Wünsche B, Fähnrich H, Mentzel HJ, Vogt S, et al. Ultrasound bone densitometry of the Os calcis in children and adolescents. Calcif Tissue Int 2000;67:349–55.10.1007/s002230001143Suche in Google Scholar PubMed
31. Ahuja SP, Greenspan SL, Lin Y, Bowen AD, Bartels D, et al. A pilot study of heel ultrasound to screen for low bone mass in children with leukemia. J Pediatr Hematol Oncol 2006;28:427–32.10.1097/01.mph.0000212946.28103.29Suche in Google Scholar PubMed
32. Frost ML, Blake GM, Fogelman I. Can the WHO criteria for diagnosing osteoporosis be applied to calcaneal quantitative ultrasound? Osteoporos Int 2000;11:321–30.10.1007/s001980070121Suche in Google Scholar PubMed
33. Baim S, Leonard MB, Bianchi ML, Hans DB, Kalkwarf HJ, et al. Official positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Pediatric Position Development Conference. J Clin Densitom 2008;11:6–21.10.1016/j.jocd.2007.12.002Suche in Google Scholar PubMed
34. Kobayashi S, Inoue S, Hosoi T, Ouchi Y, Shiraki M, et al. Association of bone mineral density with polymorphism of the estrogen receptor gene. J Bone Miner Res 1996;11:306–11.10.1002/jbmr.5650110304Suche in Google Scholar PubMed
35. Wood RJ, Fleet JC. The genetics of osteoporosis: vitamin D receptor polymorphisms. Annu Rev Nutr 1998;18:233–58.10.1146/annurev.nutr.18.1.233Suche in Google Scholar PubMed
36. Wang KJ, Shi DQ, Sun LS, Jiang X, Lü YY, et al. Association of estrogen receptor alpha gene polymorphisms with bone mineral density: a meta-analysis. Chin Med J (Engl) 2012;125:2589–97.Suche in Google Scholar PubMed
37. Ioannidis JP, Stavrou I, Trikalinos TA, Zois C, Brandi ML, et al. Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis. J Bone Miner Res 2002;17:2048–60.10.1359/jbmr.2002.17.11.2048Suche in Google Scholar PubMed
38. Zhu H, Jiang J, Wang Q, Zong J, Zhang L, et al. Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis. BMC Endocr Disord 2018;18:11.10.1186/s12902-018-0230-xSuche in Google Scholar PubMed
39. Castro J, Lázaro L, Pons F, Halperin I, Toro J. Predictors of bone mineral density reduction in adolescents with anorexia nervosa. J Am Acad Child Adolesc Psychiat 2000;39:1365–70.10.1097/00004583-200011000-00010Suche in Google Scholar
40. Schneider M, Fisher M, Weinerman S, Lesser M. Correlates of low bone density in females with anorexia nervosa. J Adolesc Heal 2017;18:115.10.1016/1054-139X(96)81146-3Suche in Google Scholar
41. Faje AT, Fazeli PK, Miller KK, Katzman DK, Ebrahimi S, et al. Fracture risk and areal bone mineral density in adolescent females with anorexia nervosa. Int J Eat Disord 2014;47:458–66.10.1002/eat.22248Suche in Google Scholar PubMed PubMed Central
42. Kurt O, Yilmaz-Aydogan H, Uyar M, Isbir T, Seyhan MF, et al. Evaluation of ER and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women. Mol Biol Rep 2012;39:6723–30.10.1007/s11033-012-1496-0Suche in Google Scholar PubMed
43. Yavuz DG, Yoldemir T, Erenus M. Estrogen receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density. Climacteric 2012;15:368–73.10.3109/13697137.2011.617851Suche in Google Scholar PubMed
44. Gogas Yavuz D, Keskin L, Kıyıcı S, Sert M, Yazıcı D, et al. Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients. Acta Diabetol 2011;48:329–36.10.1007/s00592-011-0284-ySuche in Google Scholar PubMed
©2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Mini Review
- Can preimplantation genetic diagnosis be used for monogenic endocrine diseases?
- Original Articles
- The distribution of intrafamilial CYP21A2 mutant alleles and investigation of clinical features in Turkish children and their siblings in Southeastern Anatolia
- 3-Methylcrotonyl-CoA carboxylase deficiency newborn screening in a population of 536,008: is routine screening necessary?
- Long non-coding RNA HCP5 serves as a ceRNA sponging miR-17-5p and miR-27a/b to regulate the pathogenesis of childhood obesity via the MAPK signaling pathway
- Once-weekly supervised combined training improves neurocognitive and psychobehavioral outcomes in young patients with type 1 diabetes mellitus
- Associations between thyroid-stimulating hormone, blood pressure and adiponectin are attenuated in children and adolescents with overweight or obesity
- Mental health of both child and parents plays a larger role in the health-related quality of life of obese and overweight children
- Near final adult height, and body mass index in overweight/obese and normal-weight children with idiopathic central precocious puberty and treated with gonadotropin-releasing hormone analogs
- Effects of vitamin D and estrogen receptor polymorphisms on bone mineral density in adolescents with anorexia nervosa
- Case Reports
- Whole exome sequencing identified a heterozygous KCNJ2 missense variant underlying autosomal dominant familial hypokalemic periodic paralysis in a Pakistani family
- Infantile cerebral infarction caused by severe diabetic ketoacidosis in new-onset type 1 diabetes mellitus
- Gallstone formation due to rapid weight loss through hyperthyroidism
- A neonate with mucolipidosis II and transient secondary hyperparathyroidism
- Zoledronate-responsive calcitriol-mediated hypercalcemia in a 5-year-old case with squamous cell carcinoma on the background of xeroderma pigmentosum
Artikel in diesem Heft
- Frontmatter
- Mini Review
- Can preimplantation genetic diagnosis be used for monogenic endocrine diseases?
- Original Articles
- The distribution of intrafamilial CYP21A2 mutant alleles and investigation of clinical features in Turkish children and their siblings in Southeastern Anatolia
- 3-Methylcrotonyl-CoA carboxylase deficiency newborn screening in a population of 536,008: is routine screening necessary?
- Long non-coding RNA HCP5 serves as a ceRNA sponging miR-17-5p and miR-27a/b to regulate the pathogenesis of childhood obesity via the MAPK signaling pathway
- Once-weekly supervised combined training improves neurocognitive and psychobehavioral outcomes in young patients with type 1 diabetes mellitus
- Associations between thyroid-stimulating hormone, blood pressure and adiponectin are attenuated in children and adolescents with overweight or obesity
- Mental health of both child and parents plays a larger role in the health-related quality of life of obese and overweight children
- Near final adult height, and body mass index in overweight/obese and normal-weight children with idiopathic central precocious puberty and treated with gonadotropin-releasing hormone analogs
- Effects of vitamin D and estrogen receptor polymorphisms on bone mineral density in adolescents with anorexia nervosa
- Case Reports
- Whole exome sequencing identified a heterozygous KCNJ2 missense variant underlying autosomal dominant familial hypokalemic periodic paralysis in a Pakistani family
- Infantile cerebral infarction caused by severe diabetic ketoacidosis in new-onset type 1 diabetes mellitus
- Gallstone formation due to rapid weight loss through hyperthyroidism
- A neonate with mucolipidosis II and transient secondary hyperparathyroidism
- Zoledronate-responsive calcitriol-mediated hypercalcemia in a 5-year-old case with squamous cell carcinoma on the background of xeroderma pigmentosum
