Use of complementary and alternative medicine in patients with inherited metabolic disease
-
Sahin Erdol
and
Halil Saglam
Abstract
Background
There are no studies on the use of complementary and alternative medicine (CAM) therapies in subjects with inherited metabolic disease (IMD) in the current literature. This study aimed to determine the type, frequency of and reasons for the use, and factors associated with the use of CAM therapies.
Methods
Subjects included in this study consisted of 335 children (95.7%) and 15 (4.3%) adults with a median age of 5.66±6.16 (0.08–48) years with inherited metabolic disease. A single physician conducted face-to-face interviews with the mother and/or father for pediatric subjects and with the subjects themselves for adults of a normal intelligence. Data were obtained from responses to the questions in the standard survey form.
Results
Our study included 350 patients in total, of whom 164 (46.9%) were female and 186 (53.1%) male. We found that 144 of the patients (41.1%) had used at least one CAM therapy method. The highest rate of use among the CAM therapy methods was of the mind-body approach therapies (n=98, 28%). This was followed by biologically-based (n=75, 21.4%) and manipulative and body-based (n=5, 1.4%) therapies, respectively. The most commonly used herbal product was herbal tea (n=21, 6%), and the most commonly used dietary supplementation was a royal jelly and pollen mixture (n=9, 2.6%). Significant differences in the subjects’ age, their follow-up duration, their mother’s and father’s ages, and CAM therapy use were identified from sociodemographic data.
Conclusions
In our study, the use of CAM therapies was determined at a high rate. This is important when dealing with clinical problems and for clinicians who follow-up with IMD subjects and suspect they may be using CAM therapy.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Kelly KM. Bringing evidence to complementary and alternative medicine in children with cancer: focus on nutrion-related therapies. Pediatr Blood Cancer 2008;50:490–3.10.1002/pbc.21402Search in Google Scholar PubMed
2. Wong C. Five types of Complementary and Alternative Medicine. 12 February 2016. Available at: http://altmedicine.about.com/od/alternativemedicinebasics/a/types.htm. Accessed: 01 January 2018.Search in Google Scholar
3. Kelly KM, Jacobsan JS, Kennendy DD, Braudt SM, Mallick M, et al. Use of unconventional therapies by children with cancer at an urban medical center. J Pediatr Hematol Oncol 2000;22:412–6.10.1097/00043426-200009000-00005Search in Google Scholar PubMed
4. Kelly KM. Comlementary and alternative medicines for use in supportive care in pediatric cancer. Support Care Cancer 2007;15:457–60.10.1007/s00520-006-0162-2Search in Google Scholar PubMed
5. Vlieger AM, Blink M, Tromp E, Benninga MA. Use of complementary and alternative medicine by pediatric patients with functional and organic gastrointestinal diseases: results from a multicenter survey. Pediatrics 2008;122:446–51.10.1542/peds.2008-0266Search in Google Scholar PubMed
6. Bahall M. Prevalence, patterns, and perceived value of complementary and alternative medicine among HIV patients: a descriptive study. BMC Complement Altern Med 2017;17:422.10.1186/s12906-017-1928-4Search in Google Scholar PubMed PubMed Central
7. Kamel FO, Magadmi RM, Hagras MM, Magadmi B, AlAhmad RA. Knowledge, attitude, and beliefs toward traditional herbal medicine use among diabetics in Jeddah Saudi Arabia. Complement Ther Clin Pract 2017;29:207–12.10.1016/j.ctcp.2017.10.007Search in Google Scholar PubMed
8. Ayele AA, Tegegn HG, Haile KT, Belachew SA, Mersha AG, et al. Complementary and alternative medicine use among elderly patients living with chronic diseases in a teaching hospital in Ethiopia. Complement Ther Med 2017;35: 115–9.10.1016/j.ctim.2017.10.006Search in Google Scholar PubMed
9. Balwani M, Fuerstman L, Desnick RJ, Buckley B, Margaret MG. Use of complementary and alternative medicine by patients with lysosomal storage diseases. Genet Med 2009; 11:722–7.10.1097/GIM.0b013e3181b182c3Search in Google Scholar PubMed
10. Saudubray JM, Cazorla AG. Clinical approach to inborn errors of metabolism in pediatrics. In: Saudubray JM, Baumgartner MR, Walter John H, editors. Inborn metabolic diseases. Berlin: Springer-Verlag, 2016:3–69.10.1007/978-3-662-49771-5_1Search in Google Scholar
11. Kemppainen LM, Kemppainen TT, Reippainen JA, Salmenniemi ST, Vuolanto PH. Use of complementary and alternative medicine in Europe: health-related and sociodemographic determinants. Scand J Public Health 2018;46:448–55.10.1177/1403494817733869Search in Google Scholar PubMed PubMed Central
12. Sobo EJ. Parent use of cannabis for intractable pediatric epilepsy: everyday empiricism and the boundaries of scientific medicine. Soc Sci Med 2017;190:190–8.10.1016/j.socscimed.2017.08.003Search in Google Scholar PubMed
13. Judaki A, Rahmani A, Feizi J, Asadollahi K, Hafezi Ahmadi MR. Curcumin in combination with triple therapy regimes ameliorates oxidative stress and histopathologic changes in chronic gastritis-associated Helicobacter pylori infection. Arq Gastroenterol 2017;54:177–82.10.1590/s0004-2803.201700000-18Search in Google Scholar PubMed
14. Cheifetz AS, Gianotti R, Luber R, Gibson PR. Complementary and alternative medicines used by patients with inflammatory bowel diseases. Gastroenterology 2017;152:415–29.10.1053/j.gastro.2016.10.004Search in Google Scholar PubMed
15. Damião AO. Complementary and alternative medicine: a world to be explored. Arq Gastroenterol 2017;54:175–6.10.1590/s0004-2803.201700000-16Search in Google Scholar PubMed
©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Original Articles
- The associations between mental health, health-related quality of life and insulin pump therapy among children and adolescents with type 1 diabetes
- Achieving target levels for vascular risk parameters in Polish school-age children with type 1 diabetes – a single center study
- Adipocyte aquaporin 7 (AQP7) expression in lean children and children with obesity. Possible involvement in molecular mechanisms of childhood obesity
- Use of complementary and alternative medicine in patients with inherited metabolic disease
- Are breast milk adipokines affected by maternal dietary factors?
- Comparison of serum 25-hydroxyvitamin D levels between radioimmunoassay and liquid chromatography-tandem mass spectrometry in infants and postpartum women
- Reference intervals for neonatal thyroid function tests in the first 7 days of life
- Treatment outcomes in pediatric differentiated thyroid carcinoma
- Seasonality of month of birth in children and adolescents with autoimmune thyroiditis: a continuing conundrum
- Follow-up in children with non-obese and non-autoimmune subclinical hypothyroidism
- Glucose intolerance in children with cystic fibrosis: a developing country’s perspective
- Letter to the Editor
- A patient with classical galactosemia is graduated with a university degree
- Case Reports
- Prepubertal gynaecomastia in a boy with Peutz-Jeghers syndrome: managing the aromatase overexpression
- Hypogammaglobulinemia and imaging features in a patient with infantile free sialic acid storage disease (ISSD) and a novel mutation in the SLC17A5 gene
- Xanthogranuloma of the sellar region accompanied by growth hormone deficiency: case report and literature review
- A case of Graves’ disease associated with membranoproliferative glomerulonephritis and leukocytoclastic vasculitis
Articles in the same Issue
- Frontmatter
- Original Articles
- The associations between mental health, health-related quality of life and insulin pump therapy among children and adolescents with type 1 diabetes
- Achieving target levels for vascular risk parameters in Polish school-age children with type 1 diabetes – a single center study
- Adipocyte aquaporin 7 (AQP7) expression in lean children and children with obesity. Possible involvement in molecular mechanisms of childhood obesity
- Use of complementary and alternative medicine in patients with inherited metabolic disease
- Are breast milk adipokines affected by maternal dietary factors?
- Comparison of serum 25-hydroxyvitamin D levels between radioimmunoassay and liquid chromatography-tandem mass spectrometry in infants and postpartum women
- Reference intervals for neonatal thyroid function tests in the first 7 days of life
- Treatment outcomes in pediatric differentiated thyroid carcinoma
- Seasonality of month of birth in children and adolescents with autoimmune thyroiditis: a continuing conundrum
- Follow-up in children with non-obese and non-autoimmune subclinical hypothyroidism
- Glucose intolerance in children with cystic fibrosis: a developing country’s perspective
- Letter to the Editor
- A patient with classical galactosemia is graduated with a university degree
- Case Reports
- Prepubertal gynaecomastia in a boy with Peutz-Jeghers syndrome: managing the aromatase overexpression
- Hypogammaglobulinemia and imaging features in a patient with infantile free sialic acid storage disease (ISSD) and a novel mutation in the SLC17A5 gene
- Xanthogranuloma of the sellar region accompanied by growth hormone deficiency: case report and literature review
- A case of Graves’ disease associated with membranoproliferative glomerulonephritis and leukocytoclastic vasculitis
