Van Wyk-Grumbach syndrome with hemangioma in an infant
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Moumita Biswas
Abstract
Background
Van Wyk-Grumbach syndrome (VWGS) is characterized by juvenile primary hypothyroidism, delayed bone age and isosexual incomplete precocious puberty with reversal to the prepubertal state following thyroid hormone replacement.
Case presentation
In this case, an 18-month-old girl presented with premature menarche since 9 months of age, delayed bone age and enlarged bilateral multicystic ovaries along with a superficial infantile hemangioma over the upper anterior chest. VWGS was diagnosed based on the clinical features. High serum thyroid stimulating hormone and low free thyroxine with the absence of any carpal bones in the wrist X-ray were suggestive of congenital hypothyroidism. Interestingly, the coexisting hemangioma could also play a role in the etiology of the hypothyroidism through “consumptive hypothyroidism”. Thyroid hormone replacement resulted in the complete resolution of signs and symptoms.
Conclusions
Untreated congenital hypothyroidism of short duration, onset of symptoms in infancy and association of an infantile hemangioma in VWGS were the unique features in our case.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Intracranial pathologies associated with central diabetes insipidus in infants
- Omentin-1 and NAMPT serum concentrations are higher and CK-18 levels are lower in children and adolescents with type 1 diabetes when compared to healthy age, sex and BMI matched controls
- Evaluation of anthropometric parameters of central obesity in Pakistani children aged 5–12 years, using receiver operating characteristic (ROC) analysis
- A lower energetic, protein and uncooked cornstarch intake is associated with a more severe outcome in glycogen storage disease type III: an observational study of 50 patients
- Untreated congenital hypothyroidism due to loss to follow-up: developing preventive strategies through quality improvement
- The effect of 17 years of increased salt iodization on the prevalence and nature of goiter in Croatian schoolchildren
- Is there an association between thyrotropin levels within the normal range and birth growth parameters in full-term newborns?
- Etiology of short stature in Indian children and an assessment of the growth hormone-insulin-like growth factor axis in children with idiopathic short stature
- Growth of patients with congenital adrenal hyperplasia due to 21-hydroxylase in infancy, glucocorticoid requirement and the role of mineralocorticoid therapy
- A personal series of 100 children operated for Cushing’s disease (CD): optimizing minimally invasive diagnosis and transnasal surgery to achieve nearly 100% remission including reoperations
- 12-Week aerobic exercise and nutritional program minimized the presence of the 64Arg allele on insulin resistance
- Letter to the Editor
- Successful treatment of life-threatening severe metabolic acidosis by continuous veno-venous hemodialysis in a child with diabetic ketoacidosis
- Case Reports
- Two siblings with metachromatic leukodystrophy caused by a novel identified homozygous mutation in the ARSA gene
- To diet or not to diet in neonatal diabetes responding to sulfonylurea treatment
- Van Wyk-Grumbach syndrome with hemangioma in an infant
- Maternal iodine excess: an uncommon cause of acquired neonatal hypothyroidism
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Intracranial pathologies associated with central diabetes insipidus in infants
- Omentin-1 and NAMPT serum concentrations are higher and CK-18 levels are lower in children and adolescents with type 1 diabetes when compared to healthy age, sex and BMI matched controls
- Evaluation of anthropometric parameters of central obesity in Pakistani children aged 5–12 years, using receiver operating characteristic (ROC) analysis
- A lower energetic, protein and uncooked cornstarch intake is associated with a more severe outcome in glycogen storage disease type III: an observational study of 50 patients
- Untreated congenital hypothyroidism due to loss to follow-up: developing preventive strategies through quality improvement
- The effect of 17 years of increased salt iodization on the prevalence and nature of goiter in Croatian schoolchildren
- Is there an association between thyrotropin levels within the normal range and birth growth parameters in full-term newborns?
- Etiology of short stature in Indian children and an assessment of the growth hormone-insulin-like growth factor axis in children with idiopathic short stature
- Growth of patients with congenital adrenal hyperplasia due to 21-hydroxylase in infancy, glucocorticoid requirement and the role of mineralocorticoid therapy
- A personal series of 100 children operated for Cushing’s disease (CD): optimizing minimally invasive diagnosis and transnasal surgery to achieve nearly 100% remission including reoperations
- 12-Week aerobic exercise and nutritional program minimized the presence of the 64Arg allele on insulin resistance
- Letter to the Editor
- Successful treatment of life-threatening severe metabolic acidosis by continuous veno-venous hemodialysis in a child with diabetic ketoacidosis
- Case Reports
- Two siblings with metachromatic leukodystrophy caused by a novel identified homozygous mutation in the ARSA gene
- To diet or not to diet in neonatal diabetes responding to sulfonylurea treatment
- Van Wyk-Grumbach syndrome with hemangioma in an infant
- Maternal iodine excess: an uncommon cause of acquired neonatal hypothyroidism
