Metabolic features and changes in glucose-induced serum glucagon-like peptide-1 levels in children with hypothalamic obesity
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Rapeepun Chai-udom
Abstract
Background
Hypothalamic damage may alter glucagon-like peptide-1 (GLP-1) secretion and be involved in the pathogenesis of obesity. We aim to evaluate the metabolic features and the dynamic changes of GLP-1 levels during an oral glucose tolerance test (OGTT) in children with hypothalamic obesity (HO) compared with simple obesity controls.
Methods
Subjects included eight patients (six females, aged 9–16 years) with hypothalamo-pituitary tumors who later developed obesity and eight controls with simple obesity matched for age, body mass index (BMI), gender and puberty. We assessed the metabolic syndrome features, fat mass, severity of hyperphagia using a standardized questionnaire, and measured glucose, insulin and GLP-1 levels during a standard 75 g OGTT.
Results
Age, gender distribution, pubertal status and BMI-Z scores were not significantly different. Subjects with HO had higher fasting triglycerides (TG) than controls (128 vs. 94 mg/dL; p=0.05). Four HO subjects and three controls met the criteria for the metabolic syndrome. Fasting and 120 min post-glucose load GLP-1 levels were significantly higher in HO patients than in controls (21.9 vs. 19.7 pg/mL; p=0.025, 22.1 vs. 17.7 pg/mL; p=0.012). Patients with HO had significantly higher hyperphagia scores than in simple obese controls (13 vs. 2.5; p=0.012).
Conclusions
Patients with HO appear to have more metabolic complications and hyperphagia than controls with simple obesity. Impaired satiety may play an important role in HO. Fasting and glucose-induced serum GLP-1 concentrations seem to be altered in HO patients and could be a part of the pathogenesis of HO.
Acknowledgments
We would like to thank the patients and their families for participation in this study.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This study was supported by the Ratchadapiseksompotch Fund (RA59/058), Faculty of Medicine, Chulalongkorn University and the Thailand Research Fund (IRG5780015), Funder Id: 10.13039/501100004396.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Original Articles
- Vitamin D status in Israeli pediatric type 1 diabetes patients: the AWeSoMe Study Group experience and literature review
- Metabolic features and changes in glucose-induced serum glucagon-like peptide-1 levels in children with hypothalamic obesity
- Assessment of intima-media thickness of the carotid artery and intraluminal diameter of the brachial artery as cardiovascular risk markers in Brazilian adolescents with overweight or obesity
- The role of LCPUFA-ω3 on the obesity-associated hyperandrogenemia of pubertal girls: secondary analysis of a randomized clinical trial
- Genetic variants of the phenylalanine hydroxylase gene in patients with phenylketonuria in the northeast of Iran
- Oral health status of children with phenylketonuria
- Birth weight related blood concentrations of the neurotransmission amino acids glutamine plus glutamate, phenylalanine and tyrosine in full-term breastfed infants perinatally
- Hyperthyrotropinemia is common in preterm infants who are born small for gestational age
- Radioactive iodine therapy for pediatric Graves’ disease: a single-center experience over a 10-year period
- The decision-making levels of urine tetrasaccharide for the diagnosis of Pompe disease in the Turkish population
- A questionnaire study on sleep disturbances associated with Prader-Willi syndrome
- Body size measurements, digit ratio (2D:4D) and oestrogen and progesterone receptors’ expressions in juvenile gigantomastia
- The effect of celiac disease and gluten-free diet on pubertal development: a two-center study
- Observational study of disorders of sex development in Yaounde, Cameroon
- Letter to the Editor
- Reforming the male Tanner genital scale
- Short Communication
- The association between vitamin D levels and precocious puberty: a meta-analysis
- Case Reports
- Partial trisomy 9p and 14q microduplication in a patient with growth retardation: a case report and review of the literature
- Two different missense mutations of PEX genes in two similar patients with severe Zellweger syndrome: an argument on the genotype-phenotype correlation
- Patient report
- Marked phenotypic variable expression among brothers with duplication of Xq27.1 involving the SOX3 gene
- Case Report
- Does the risk of arterial hypertension increase in the course of triptorelin treatment?
Articles in the same Issue
- Frontmatter
- Original Articles
- Vitamin D status in Israeli pediatric type 1 diabetes patients: the AWeSoMe Study Group experience and literature review
- Metabolic features and changes in glucose-induced serum glucagon-like peptide-1 levels in children with hypothalamic obesity
- Assessment of intima-media thickness of the carotid artery and intraluminal diameter of the brachial artery as cardiovascular risk markers in Brazilian adolescents with overweight or obesity
- The role of LCPUFA-ω3 on the obesity-associated hyperandrogenemia of pubertal girls: secondary analysis of a randomized clinical trial
- Genetic variants of the phenylalanine hydroxylase gene in patients with phenylketonuria in the northeast of Iran
- Oral health status of children with phenylketonuria
- Birth weight related blood concentrations of the neurotransmission amino acids glutamine plus glutamate, phenylalanine and tyrosine in full-term breastfed infants perinatally
- Hyperthyrotropinemia is common in preterm infants who are born small for gestational age
- Radioactive iodine therapy for pediatric Graves’ disease: a single-center experience over a 10-year period
- The decision-making levels of urine tetrasaccharide for the diagnosis of Pompe disease in the Turkish population
- A questionnaire study on sleep disturbances associated with Prader-Willi syndrome
- Body size measurements, digit ratio (2D:4D) and oestrogen and progesterone receptors’ expressions in juvenile gigantomastia
- The effect of celiac disease and gluten-free diet on pubertal development: a two-center study
- Observational study of disorders of sex development in Yaounde, Cameroon
- Letter to the Editor
- Reforming the male Tanner genital scale
- Short Communication
- The association between vitamin D levels and precocious puberty: a meta-analysis
- Case Reports
- Partial trisomy 9p and 14q microduplication in a patient with growth retardation: a case report and review of the literature
- Two different missense mutations of PEX genes in two similar patients with severe Zellweger syndrome: an argument on the genotype-phenotype correlation
- Patient report
- Marked phenotypic variable expression among brothers with duplication of Xq27.1 involving the SOX3 gene
- Case Report
- Does the risk of arterial hypertension increase in the course of triptorelin treatment?
