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Assessment of insulin like growth factor-1 and IGF binding protein-3 in healthy Indian girls from Delhi and their correlation with age, pubertal status, obesity and thyroid hormonal status

  • Raman K. Marwaha EMAIL logo , M.K. Garg , Sushil Gupta , A.K. Khurana , Archna Narang , Manoj Shukla , Preeti Arora , Aditi Chadha , Deb Datta Nayak and R.K. Manchanda
Published/Copyright: June 23, 2017
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 30 Issue 7

Abstract

Background:

Population specific data and influence of sub-clinical hypothyroidism on insulin like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3) in Indian children is lacking. This study was undertaken to evaluate serum IGF-1 and IGFBP-3 and their correlation with age, gender, pubertal status and thyroid functions.

Methods:

A total of 840 apparently healthy school girls aged 6–18 years, were recruited for the study and underwent assessment of height, weight, body mass index, pubertal status and serum T3, T4, TSH, IGF-1, IGFBP-3 and IGF-1/IGFBP-3 molar ratio.

Results:

The mean serum levels of IGF-1, IGFBP-3 levels and IGF-1/IGFBP-3 molar ratio were 381.8±240.5 ng/mL, 4.19±2.08 μg/mL and 40.5±37.2%, respectively. The serum IGF-1 and IGF-1/IGFBP-3 molar ratio increased significantly (p<0.0001) at 11 years followed by a steady yet non-significant rise till 16 years of age. A similar pattern was observed for IGFBP-3 showing a steep rise at 12 years and peaking at 16 years. Likewise, serum levels of IGF-1 and molar ratio of IGF-1/IGFBP-3 increased significantly with pubertal maturation from stage 1 to 3 and were higher in overweight girls compared to normal weight and obese girls. The growth factors were no different in girls with or without subclinical hypothyroidism.

Conclusions:

There was no significant impact of age on IGF-1 and IGFBP-3 in pre-pubertal girls. A sudden marked increase at 11 years followed by a gradual rise in growth factors till 16 years is indicative of pubertal initiation and maturation. Subclinical hypothyroidism did not influence growth factors in girls.

Keywords: adolescent girls; insulin like growth factor-1; IGF-binding protein-3; IGF-1/IGFBP-3 molar ratio; puberty; subclinical hypothyroidism
Corresponding author: Maj Gen (Retd). Dr. Raman K. Marwaha, Senior Consultant Endocrinology and Scientific Advisor (Projects), ILSI-India, Flat No 17, Gautam Apartments, Gautam Nagar, New Delhi 110049, India, Phone: +91 9810296820; Fax: +91 11 26523477

Acknowledgments

The authors gratefully acknowledge the assistance and participation of school principals, children and their parents in carrying this study. The assistance of the following team members is also gratefully acknowledged: Mrs. Pamela Marwaha, Dr. S.K. Mathur, Mrs. Neeru Gandhi, Dristhi Sharma, Archita Gupta and Shrijan Jaipuriar.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: Financial support was provided by the Central Council of Research in Homeopathy, Ministry of Ayush, India.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Accepted: 2017-5-19
Published Online: 2017-6-23
Published in Print: 2017-7-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. High prevalence of organ specific autoantibodies in Indian type 1 diabetic patients
  4. Improved metabolic control in tetrahydrobiopterin (BH4), responsive phenylketonuria with sapropterin administered in two divided doses vs. a single daily dose
  5. Excessive weight gain in exclusively breast-fed infants
  6. Comparison of Tanner staging of HIV-infected and uninfected girls at the University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria
  7. Joint association of screen time and physical activity with anthropometric measures in Iranian children and adolescents: the weight disorders survey of the CASPIAN-IV study
  8. Assessment of insulin like growth factor-1 and IGF binding protein-3 in healthy Indian girls from Delhi and their correlation with age, pubertal status, obesity and thyroid hormonal status
  9. Impact of discontinuation of growth hormone treatment on lipids and weight status in adolescents
  10. Clinical, biochemical and genetic features with nonclassical 21-hydroxylase deficiency and final height
  11. A combined approach to generate laboratory reference intervals using unbalanced longitudinal data
  12. Clinical evaluation and mutational analysis of GALK and GALE genes in patients with galactosemia in Greece: one novel mutation and two rare cases
  13. Case Reports
  14. Pediatric toxic polycystic thyroid
  15. In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature
  16. Postprandial hyperinsulinemic hypoglycemia in a child as a late complication of esophageal reconstruction
  17. Long-term follow-up of a child with Klinefelter syndrome and achondroplasia from infancy to 16 years
https://doi.org/10.1515/jpem-2016-0359
Keywords for this article
adolescent girls; insulin like growth factor-1; IGF-binding protein-3; IGF-1/IGFBP-3 molar ratio; puberty; subclinical hypothyroidism

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. High prevalence of organ specific autoantibodies in Indian type 1 diabetic patients
  4. Improved metabolic control in tetrahydrobiopterin (BH4), responsive phenylketonuria with sapropterin administered in two divided doses vs. a single daily dose
  5. Excessive weight gain in exclusively breast-fed infants
  6. Comparison of Tanner staging of HIV-infected and uninfected girls at the University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria
  7. Joint association of screen time and physical activity with anthropometric measures in Iranian children and adolescents: the weight disorders survey of the CASPIAN-IV study
  8. Assessment of insulin like growth factor-1 and IGF binding protein-3 in healthy Indian girls from Delhi and their correlation with age, pubertal status, obesity and thyroid hormonal status
  9. Impact of discontinuation of growth hormone treatment on lipids and weight status in adolescents
  10. Clinical, biochemical and genetic features with nonclassical 21-hydroxylase deficiency and final height
  11. A combined approach to generate laboratory reference intervals using unbalanced longitudinal data
  12. Clinical evaluation and mutational analysis of GALK and GALE genes in patients with galactosemia in Greece: one novel mutation and two rare cases
  13. Case Reports
  14. Pediatric toxic polycystic thyroid
  15. In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature
  16. Postprandial hyperinsulinemic hypoglycemia in a child as a late complication of esophageal reconstruction
  17. Long-term follow-up of a child with Klinefelter syndrome and achondroplasia from infancy to 16 years
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