Pediatric differentiated thyroid carcinoma: trends in practice and outcomes over 40 years at a single tertiary care institution
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Courtney Olmsted
Abstract
Background:
This study aims to analyze changes in characteristics, practice and outcomes of pediatric differentiated thyroid cancer (DTC) at our tertiary care institution.
Methods:
Patients <21 years of age diagnosed between 1973 and 2013 were identified. Clinicopathological data, treatment and outcomes were obtained by a retrospective review.
Results:
Thirteen males and 68 females were divided into Group A (n=35, diagnosed before July 1993) and Group B (n=46, diagnosed after July 1993). Group B was more likely to undergo neck ultrasound (US) (70% vs. 23%, p<0.0001) and fine-needle aspiration (FNA) biopsy (80% vs. 26%, p<0.0001). Patients in Group B more often underwent total thyroidectomy as a definitive surgical treatment (87% vs. 69%, p=0.04). There was no difference in radioactive iodine use. Recurrence-free survival was similar.
Conclusions:
Increased use of US and FNA has affected initial surgical management in the latter part of the study, possibly due to extension of adult DTC guidelines. The effects of the new pediatric DTC guidelines need further study.
Acknowledgments
Dr. Olmsted was supported by the VA Quality Scholars Fellowship Program, VA Office of Academic Affiliation.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. The authors also wish to thank Dr. Charles F. Lynch from the Iowa Cancer Registry for assistance with study patient identification.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
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Artikel in diesem Heft
- Frontmatter
- Review
- Individualised growth response optimisation (iGRO) tool: an accessible and easy-to-use growth prediction system to enable treatment optimisation for children treated with growth hormone
- Original Articles
- Relation of insulin resistance to neurocognitive function and electroencephalography in obese children
- Body weight misperception and health-related factors among Iranian children and adolescents: the CASPIAN-V study
- Do sufficient vitamin D levels at the end of summer in children and adolescents provide an assurance of vitamin D sufficiency at the end of winter? A cohort study
- Type 3 renal tubular acidosis associated with growth hormone deficiency
- Serum α-klotho levels are not informative for the evaluation of growth hormone secretion in short children
- Evaluation of neurodevelopment of children with congenital hypothyroidism by the Denver Developmental Screening Test
- Pediatric differentiated thyroid carcinoma: trends in practice and outcomes over 40 years at a single tertiary care institution
- Physical activity and bone mineral density at the femoral neck subregions in adolescents with Down syndrome
- A pilot study on the utility of reduced urine collection frequency protocols for the assessment of reproductive hormones in adolescent girls
- MODY in Ukraine: genes, clinical phenotypes and treatment
- A retrospective review of initial bisphosphonate infusion in an inpatient vs. outpatient setting for bisphosphonate naïve patients
- Molecular genetic and clinical delineation of 22 patients with congenital hypogonadotropic hypogonadism
- Letter to the Editor
- Rare cases of galactose metabolic disorders: identification of more than two mutations per patient
- Case Reports
- When one disease is not enough: succinyl-CoA: 3-oxoacid coenzyme A transferase (SCOT) deficiency due to a novel mutation in OXCT1 in an infant with known phenylketonuria
- Pseudohypoparathyroidism type 1B associated with assisted reproductive technology
- Long QT syndrome diagnosed in two sisters with propionic acidemia: a case report
- Delayed diagnosis of proopiomelanocortin (POMC) deficiency with type 1 diabetes in a 9-year-old girl and her infant sibling
