Relation of fetuin A levels with cardiac, subcutaneous lipid accumulation and insulin resistance parameters in Turkish obese children
-
Şamil Hızlı
,
Ayhan Abacı
Abstract
Background: Fetuin A is an inhibitor of insulin action and have been found to be related with subcutaneous lipid accumulation and insulin resistance. The relation of cardiac lipid accumulation, fetuin A and insulin resistance parameters in obese children is not well-known. The aim of the study was to evaluate the relation of serum fetuin A levels with subcutaneous and cardiac lipid accumulation, and insulin resistance parameters in Turkish obese children.
Methods: Serum fetuin A levels, cardiac and subcutaneous lipid accumulation parameters of 42 obese (10.9±2.3 years, 19 female) and 40 control group subjects (11.2±2.7) were compared. Cardiac lipid accumulation measured by subepicardial adipose tissue thickness. Insulin resistance was assessed using homeostasis model assessment (HOMA-IR) index.
Results: There were significant correlations serum fetuin A levels with BMI-SDS, circumferences of waist, hip and midarm, SATT and HOMA-IR (r=0.362, p=0.018, r=0.728, p=0.001, r=0.662, p=0.0001, r=0.713, p=0.0001, r=0.477, p=0.001, and r=0.330, p=0.038 as, respectively).
Conclusions: Fetuin A was correlated well with cardiac and subcutaneous lipid accumulation, insulin resistance parameters, which may be related with early pathogenetic mechanisms of metabolic obesity complications in children.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Sypniewska G. Laboratory assessment of cardiometabolic risk in overweight and obese children. Clin Biochem 2015;48:370–6.10.1016/j.clinbiochem.2014.12.024Suche in Google Scholar
2. Masarone M, Federico A, Abenavoli L, Loguercio C, Persico M. Non alcoholic fatty liver. Epidemiology and Natural History. Rev Recent Clin Trials 2014;9:126–33.10.2174/1574887109666141216111143Suche in Google Scholar
3. Pacifico L, Nobili V, Anania C, Verdecchia P, Chiesa C. Pediatric nonalcoholic fatty liver disease, metabolic syndrome and cardiovascular risk. World J Gastroenterol 2011;17:3082–91.Suche in Google Scholar
4. Schwimmer JB, Deutsch R, Rauch JB, Behling C, Newbury R, Lavine JE. Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr 2003;143:500–5.10.1067/S0022-3476(03)00325-1Suche in Google Scholar
5. Atabek ME. Diagnosis of nonalcoholic fatty liver disease in obese children. J Pediatric Endocrinol Metab 2012;25:613.10.1515/jpem-2012-0072Suche in Google Scholar PubMed
6. Patton HM, Yates K, Unalp-Arida A, Behling CA, Huang TT, et al. Association between metabolic syndrome and liver histology among children with nonalcoholic fatty liver disease. Am J Gastroenterol 2010;105:2093–102.10.1038/ajg.2010.152Suche in Google Scholar PubMed PubMed Central
7. Srinivas PR, Wagner AS, Reddy LV, Deutsch DD, Leon MA, et al. Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Mol Endocrinol 1993;7:1445–55.Suche in Google Scholar
8. Stefan N, Hennige AM, Staiger H, Machann J, Schick F, et al. Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans. Diabetes Care 2006;29:853–7.10.2337/diacare.29.04.06.dc05-1938Suche in Google Scholar PubMed
9. Trepanowski JF, Mey J, Varady KA. Fetuin-A: a novel link between obesity and related complications. Int J Obes (Lond) 2015;39:734–41.10.1038/ijo.2014.203Suche in Google Scholar PubMed
10. Weikert C, Stefan N, Schulze MB, Pischon T, Berger K, et al. Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation 2008;118:2555–62.10.1161/CIRCULATIONAHA.108.814418Suche in Google Scholar PubMed
11. Mori K, Emoto M, Araki T, Yokoyama H, Teramura M, et al. Association of serum fetuin-A with carotid arterial stiffness. Clin Endocrinol (Oxf) 2007;66:246–50.10.1111/j.1365-2265.2006.02716.xSuche in Google Scholar PubMed
12. Jialal I, Devaraj S, Hennige AM, Staiger H, Wicke C, et al. Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS One 2008;3:1.Suche in Google Scholar
13. Bettaieb A, Haj F, Adams-Huet B. Increased adipose tissue secretion of Fetuin-A, lipopolysaccharide-binding protein and high-mobility group box protein 1 in metabolic syndrome. Atherosclerosis 2015;241:130–7.10.1016/j.atherosclerosis.2015.04.814Suche in Google Scholar PubMed
14. Mukhopadhyay S, Mondal SA, Kumar M, Dutta D. Proinflammatory and antiinflammatory attributes of fetuin-a: a novel hepatokine modulating cardiovascular and glycemic outcomes in metabolic syndrome. Endocr Pract 2014;20:1345–51.10.4158/EP14421.RASuche in Google Scholar PubMed
15. Ismail NA, Ragab S, El Dayem SM, Elbaky AA, Salah N, et al. Fetuin-A levels in obesity: differences in relation to metabolic syndrome and correlation with clinical and laboratory variables. Arch Med Sci 2012;8:826–33.10.5114/aoms.2012.31616Suche in Google Scholar PubMed PubMed Central
16. Lebensztejn DM, Białokoz-Kalinowska I, Kłusek-Oksiuta M, Tarasów E, Wojtkowska M, et al. Serum fetuin A concentration is elevated in children with non-alcoholic fatty liver disease. Adv Med Sci 2014;59:81–4.10.1016/j.advms.2013.08.003Suche in Google Scholar PubMed
17. Reinehr T, Roth CL. Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. J Clin Endocrinol Metab 2008;93:4479–85.10.1210/jc.2008-1505Suche in Google Scholar PubMed
18. Malin SK, del Rincon JP, Huang H, Kirwan JP. Exercise-induced lowering of fetuin-A may increase hepatic insulin sensitivity. Med Sci Sports Exerc 2014;46:2085–90.10.1249/MSS.0000000000000338Suche in Google Scholar PubMed PubMed Central
19. Preis SR, Massaro JM, Robins SJ, Hoffmann U, Vasan RS, et al. Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study. Obesity (Silver Spring) 2010;18:2191–8.10.1038/oby.2010.59Suche in Google Scholar PubMed PubMed Central
20. Fluchter S, Haghi D, Dinter D, Heberlein W, Kühl HP, et al. Volumetric assessment of epicardial adipose tissue with cardiovascular magnetic resonance imaging. Obesity (Silver Spring) 2007;15:870–8.10.1038/oby.2007.591Suche in Google Scholar PubMed
21. Hızlı S, Ozdemir O, Abacı A, Razi CH, Kabakuş N. Relation of subepicardial adipose tissue thickness and clinical and metabolic parameters in obese prepubertal children. Pediatr Diabetes 2010;11:556–62.10.1111/j.1399-5448.2010.00644.xSuche in Google Scholar PubMed
22. de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, et al. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 2007;85:660–7.10.2471/BLT.07.043497Suche in Google Scholar PubMed PubMed Central
23. Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115:e500–3.10.1542/peds.2004-1921Suche in Google Scholar PubMed
24. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555–76.10.1542/peds.114.S2.555Suche in Google Scholar
25. Demircioğlu F, Koçyiğit A, Arslan N, Cakmakçi H, Hizli S, et al. Intima-media thickness of carotid artery and susceptibility to atherosclerosis in obese children with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 2008;47:68–75.10.1097/MPG.0b013e31816232c9Suche in Google Scholar PubMed
26. Dahlman I, Eriksson P, Kaaman M, Jiao H, Lindgren CM, et al. Alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action. Diabetologia 2004;47:1974–9.10.1007/s00125-004-1556-7Suche in Google Scholar PubMed
27. Hizli S, Koçyigit A, Arslan N, Tuncel SA, Demircioglu F, et al. Hepatic artery resistance in children with obesity and fatty liver. Indian J Pediatr 2010;77:407–11.10.1007/s12098-010-0045-xSuche in Google Scholar PubMed
©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Review
- Medullary thyroid carcinoma: a review on ethical considerations in treatment of children
- Original Articles
- Monocyte chemoattractant protein 1 and macrophage migration inhibitory factor in children with type 1 diabetes
- Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes
- Seasonality of diagnosis of type 1 diabetes mellitus in the Netherlands (Young Dudes-2)
- Health-related quality of life in children and adolescents with type 1 diabetes mellitus from Montenegro: relationship to metabolic control
- Relation of fetuin A levels with cardiac, subcutaneous lipid accumulation and insulin resistance parameters in Turkish obese children
- Prooxidant-antioxidant balance in patients with phenylketonuria and its correlation to biochemical and hematological parameters
- Serum vaspin concentrations in girls with anorexia nervosa
- Effect of intramuscular cholecalciferol megadose in children with nutritional rickets
- Focus on BMI and subclinical hypothyroidism in adolescent girls first examined for amenorrhea or oligomenorrhea. The emerging role of polycystic ovary syndrome
- Absence of a relationship between thyroid hormones and vitamin D levels
- Parathyroid hormone-ionized calcium dynamics over the first year of life
- Biochemical markers of bone turnover in children with clinical bone fragility
- Adipocytokines and bone metabolism markers in relation to bone mineral values in early pubertal boys with different physical activity
- Bone mineral density in young Chilean patients with type 1 diabetes mellitus
- Case Reports
- A case of mature teratoma with a falsely high serum estradiol value measured with an immunoassay
- Leigh syndrome associated with a novel mutation in the COX15 gene
- More than one way to skin a thyroid. Managing pediatric hypothyroidism with weekly intramuscular levothyroxine
- First case report of rare congenital adrenal insufficiency caused by mutations in the CYP11A1 gene in the Czech Republic
- Arg924X homozygous mutation in insulin receptor gene in a Tunisian patient with Donohue syndrome
- Corrigendum
- Corrigendum to: Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys
Artikel in diesem Heft
- Frontmatter
- Review
- Medullary thyroid carcinoma: a review on ethical considerations in treatment of children
- Original Articles
- Monocyte chemoattractant protein 1 and macrophage migration inhibitory factor in children with type 1 diabetes
- Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes
- Seasonality of diagnosis of type 1 diabetes mellitus in the Netherlands (Young Dudes-2)
- Health-related quality of life in children and adolescents with type 1 diabetes mellitus from Montenegro: relationship to metabolic control
- Relation of fetuin A levels with cardiac, subcutaneous lipid accumulation and insulin resistance parameters in Turkish obese children
- Prooxidant-antioxidant balance in patients with phenylketonuria and its correlation to biochemical and hematological parameters
- Serum vaspin concentrations in girls with anorexia nervosa
- Effect of intramuscular cholecalciferol megadose in children with nutritional rickets
- Focus on BMI and subclinical hypothyroidism in adolescent girls first examined for amenorrhea or oligomenorrhea. The emerging role of polycystic ovary syndrome
- Absence of a relationship between thyroid hormones and vitamin D levels
- Parathyroid hormone-ionized calcium dynamics over the first year of life
- Biochemical markers of bone turnover in children with clinical bone fragility
- Adipocytokines and bone metabolism markers in relation to bone mineral values in early pubertal boys with different physical activity
- Bone mineral density in young Chilean patients with type 1 diabetes mellitus
- Case Reports
- A case of mature teratoma with a falsely high serum estradiol value measured with an immunoassay
- Leigh syndrome associated with a novel mutation in the COX15 gene
- More than one way to skin a thyroid. Managing pediatric hypothyroidism with weekly intramuscular levothyroxine
- First case report of rare congenital adrenal insufficiency caused by mutations in the CYP11A1 gene in the Czech Republic
- Arg924X homozygous mutation in insulin receptor gene in a Tunisian patient with Donohue syndrome
- Corrigendum
- Corrigendum to: Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys
