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Prevalence of autoantibodies in type 1 diabetes patients and its association with the clinical presentation – UAE Eastern Region experience

  • Noura Al-Hassani EMAIL logo , Fares Chedid , Suha Hadi and Walid Kaplan
Published/Copyright: July 9, 2014

Abstract

Background: Positive autoantibodies and its association with the clinical course of type 1 diabetes mellitus (T1DM) have been reported worldwide, however, no such data have been reported in United Arab Emirates population.

Objectives: To study the prevalence of positive autoantibodies in T1DM pediatric patients and its association with the clinical presentation.

Methods: Descriptive retrospective chart review of all new cases of pediatric T1DM at Tawam Hospital. Electronic patient records accessed to obtain data.

Results: 61 patients were identified. 88%±8.1 had at least 1 positive antibody and 82% of all patients were positive for anti-glutamic acid decarboxylase (GAD). While comparing the group of any positive antibody (n=54) with the group of all negative antibodies (n=7), a significant difference was found in the mean HbA1C (p=0.02) and nationality (p=0.03).

Conclusion: The vast majority of our T1DM pediatric patients are autoantibody positive, and anti-GAD antibodies were the most commonly detected antibodies.


Corresponding author: Noura Al-Hassani, MD, Pediatric Department, Tawam University Hospital, PO Box 15258, Al Ain, UAE, E-mail:

References

1. Statistical analysis section – Government of Dubai. Diabetes mellitus among school age children in Dubai. Statistical News 2006;6:1–2.Search in Google Scholar

2. Charn J, Yeungb V, Chowb C, Ko GT, Mackay IR, et al. Pancreatic p cell function and antibodies to glutamic acid decarboxylase (anti-GAD) in Chinese patients with clinical diagnosis of insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 1996;32:27–34.10.1016/0168-8227(96)01203-XSearch in Google Scholar

3. Tobon G, Arango A, Abad V, García J, Cuervo H, et al. Clinical and immunological characteristics of type 1 diabetes mellitus in a northwestern Colombian population. Diabetes Res Clin Pract 2006;72:170–5.10.1016/j.diabres.2005.10.016Search in Google Scholar

4. Hakbany M, Al Mutair A, Awadalla S. Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes. Hum Immunol 2010;71:1238–42.10.1016/j.humimm.2010.09.008Search in Google Scholar

5. Yi-Ching T, Mei-Huei C, Cheng-Ting L, Wen-Yu T. β-Cell autoantibodies and their function in Taiwanese children with type 1 diabetes mellitus. J Formos Med Assoc 2009;108:856–61.10.1016/S0929-6646(09)60417-4Search in Google Scholar

6. Falorni A, Brozzetti A. Diabetes-related antibodies in adult diabetic patients. Best Pract Res Clin Endocrinol Metab 2005;19:119–33.10.1016/j.beem.2004.11.010Search in Google Scholar

7. Zimmet P. Antibodies to glutamic acid decarboxylase in the prediction insulin dependency. Diabetes Res Clin Pract 1996;34:S125–31.10.1016/S0168-8227(96)90019-4Search in Google Scholar

8. Pietropaolo M, Yu S, Libman I, Pietropaolo SL, Riley K, et al. Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes 2005;6:184–92.10.1111/j.1399-543X.2005.00127.xSearch in Google Scholar

9. Serrano-Rios M, Gutierrez- Lopez MD, Parez-Bravo F, Martínez MT, Antona J, et al. HLA-DR, DQ and anti-GAD antibodies in first degree relatives of type I diabetes mellitus. Diabetes Res Clin Pract 1996;34:S133–9.10.1016/S0168-8227(96)90020-0Search in Google Scholar

10. Al-Abbasi A, Al-Jenaidi F. Frequency of auto-antibodies in newly diagnosed Bahraini type i diabetes mellitus children and their healthy siblings. J Bahrain Med Soc 2003;15:9–12.Search in Google Scholar

11. Takeuchi Y, Ito H, Oshikiri K, Antoku S, Abe M, et al. Reduced endogenous insulin secretion in diabetic patients with low-titer positive antibodies against GAD. J Diabetes Mellitus 2012;2:96–100.10.4236/jdm.2012.21015Search in Google Scholar

12. Mortensen H, Swift P, Holl R, Hougaard P, Hansen L, et al. Multinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycemic control 12 months after diagnosis. Pediatr Diabetes 2010;11:218–26.10.1111/j.1399-5448.2009.00566.xSearch in Google Scholar PubMed

13. Hickey D, Joshy G, Dunn P, Simmons D, Lawrenson R. Glycaemic control and antibody status among Waikato, New Zealand patients with newly diagnosed type I diabetes. NZ Med J 2007;120:1–8.Search in Google Scholar

14. Sochett E, Daneman D. Relationship of insulin autoantibodies to presentation and early course of IDDM in children. Diabetes Care 1989;12:517–23.10.2337/diacare.12.8.517Search in Google Scholar PubMed

15. Al-Gazali L, Bener A, Abdulrazzaq Y, Micallef R, Al-Khayat A, et al. Consanguineous marriages in the United Arab Emirates. J Biosoc Sci 1997;29:491–7.10.1017/S0021932097004914Search in Google Scholar

16. Dabelea D, Pihoker C, Talton JW, D’Agostino RB Jr, Fujimoto W, et al. Etiological approach to characterization of diabetes type: the SEARCH for diabetes in youth study. Diabetes Care 2011;34:1628–33.10.2337/dc10-2324Search in Google Scholar PubMed PubMed Central

17. Kimpimaki T, Kumala P, Savola K, Kupila A, Korhonen S, et al. Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population. J Clin Endocrinol Metab 2002;87:4572–9.10.1210/jc.2002-020018Search in Google Scholar PubMed

18. Zanone MM, Catalfamo E, Pietropaolo SL, Rabbone I, Sacchetti C, et al. Glutamic acid decarboxylase and ICA512/IA-2 autoantibodies as disease markers and relationship to residual beta-cell function and glycemic control in young type I diabetic patients. Metabolism 2003;52:25–9.10.1053/meta.2003.50003Search in Google Scholar PubMed

19. Schenker M, Hummel M, Ferber K, Walter M, Keller E, et al. Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygous and DR4/4 homozygous offspring of parents with type I diabetes: the German BABYDIAB study. Diabetologia 1999;42:671–7.10.1007/s001250051214Search in Google Scholar PubMed

Received: 2013-11-6
Accepted: 2014-6-13
Published Online: 2014-7-9
Published in Print: 2014-11-1

©2014 by De Gruyter

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