Unresolved Problems in Optimal Therapy of Pubertal Disorders in Oncological and Bone Marrow Transplanted Patients
-
M. Bozzola
,
G.E. Butler
Abstract
Specialised clinics for the long-term follow-up of survivors from childhood cancer have developed over recent years. The problems encountered among patients who received multiple chemotherapy and radiotherapy can be challenging and require high expertise and close collaboration among different professionals (e.g. oncologists, endocrinologists, radiotherapists, psychologists). Endocrine disorders are often seen, particularly among those who received cranial radiotherapy or gonadotoxic chemotherapy; puberty can be affected and the spectrum of disorders may range from precocious or accelerated puberty to delayed, arrested or even absent pubertal development. Growth impairment can be multifactorial and growth hormone deficiency is an important but probably not the only factor involved. Many questions remain about the optimal management of this group of young patients. In the consensus guidelines that follow the overview an attempt is made to help optimise patients’ growth and puberty by suggesting practical clinical approaches to some of the most challenging issues.
© 2016 by Walter de Gruyter Berlin/Boston
Articles in the same Issue
- Titelei
- Table of Contents
- Introduction
- Opening Remarks
- Factors Determining Final Height in Congenital Adrenal Hyperplasia
- Management of Puberty for Optimal Auxological Results in β-Thalassaemia Major
- Unresolved Problems Concerning Optimal Therapy of Puberty in Children with Chronic Renal Diseases
- Management of Puberty in Constitutional Delay of Growth and Puberty
- Turner’s Syndrome
- Idiopathic Short Stature
- Current Concepts in Tall Stature and Overgrowth Syndromes
- Optimal Therapy of Pubertal Disorders in Precocious/Early Puberty
- Unresolved Problems in Optimal Therapy of Pubertal Disorders in Oncological and Bone Marrow Transplanted Patients
- Isolated Growth Hormone Deficiency in Children and Adolescents
- Multiple Pituitary Hormone Deficiency: Management of Puberty for Optimal Auxological Results
- Concluding Remarks
Articles in the same Issue
- Titelei
- Table of Contents
- Introduction
- Opening Remarks
- Factors Determining Final Height in Congenital Adrenal Hyperplasia
- Management of Puberty for Optimal Auxological Results in β-Thalassaemia Major
- Unresolved Problems Concerning Optimal Therapy of Puberty in Children with Chronic Renal Diseases
- Management of Puberty in Constitutional Delay of Growth and Puberty
- Turner’s Syndrome
- Idiopathic Short Stature
- Current Concepts in Tall Stature and Overgrowth Syndromes
- Optimal Therapy of Pubertal Disorders in Precocious/Early Puberty
- Unresolved Problems in Optimal Therapy of Pubertal Disorders in Oncological and Bone Marrow Transplanted Patients
- Isolated Growth Hormone Deficiency in Children and Adolescents
- Multiple Pituitary Hormone Deficiency: Management of Puberty for Optimal Auxological Results
- Concluding Remarks
