Maternal and Fetal Serum Insulin-like Growth Factor-I (IGF-I), IGF Binding Protein-3 (IGFBP-3), Leptin Levels and Early Postnatal Growth in Infants Born Asymmetrically Small for Gestational Age
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Zerrin Orbak
,
Şükran Darcan
Abstract
This study was planned to investigate the relationship between birth weight and insulinlike growth factor-I (IGF-I),IGF binding protein-3 (IGFBP-3), and leptin levels in neonates with normal growth (appropriate for gestational age: AGA) and retarded growth (small for gestational age: SGA); and to evaluate these growth factors’ effects in early postnatal growth. All newborns were full-term: gestational age 38-41 weeks. Of 50 neonates, 25 were SGA. IGF-I, IGFBP-3 and leptin levels were measured in maternal serum and venous cord blood at birth and at 15 days of life of neonates using specific RIAs. Maternal serum leptin concentrations were significantly higher than cord blood leptin concentrations (p <0.001). Maternal serum IGF-I, IGFBP-3 and leptin levels did not show correlations with birth weight. In contrast, there were significantly positive correlations between birth weight and venous cord blood IGF- I, IGFBP-3 and leptin levels (p <0.001). In the SGA group, the newborns with a slow postnatal growth pattern had lower umbilical cord serum IGF-I levels compared with newborns with a normal growth pattern. A similar result was also found in the AGA group. Similar results were not found for serum leptin and IGFBP-3.
In conclusion, cord blood IGF-I, IGFBP-3 and leptin levels play an important role in the regulation of fetal and neonatal growth. It is likely that IGF-I has a more important role than the other factors in early postnatal growth.
© 2016 by Walter de Gruyter Berlin/Boston
Artikel in diesem Heft
- Titelei
- Table of Contents
- Doping with Growth Hormone
- Intrauterine Diabetic Environment Confers Risks for Type 2 Diabetes Mellitus and Obesity in the Offspring, in Addition to Genetic Susceptibility
- Variable Presentation of X-linked Adrenal Hypoplasia Congenita
- Sustained Benefits of Growth Hormone on Body Composition, Fat Utilization, Physical Strength and Agility, and Growth in Prader-Willi Syndrome are Dose-Dependent
- Insufficient Adrenarche in Patients with Combined Pituitary Hormone Deficiency Caused by a PROP A Gene Defect
- Syndrome of Congenital Adrenocortical Unresponsiveness to ACTH. Report of Six Patients
- Maternal and Fetal Serum Insulin-like Growth Factor-I (IGF-I), IGF Binding Protein-3 (IGFBP-3), Leptin Levels and Early Postnatal Growth in Infants Born Asymmetrically Small for Gestational Age
- Relationships Between Levels of Leptin and Hematological Parameters in Healthy Term Infants
- Recombinant Growth Hormone Treatment in Short Patients with Thalassemia Major: Results after 24 and 36 Months
- Assessment of the Current Status of Iodine Prophylaxis in Bosnia and Herzegovina Federation
- Profiles of Obese Children Presenting for Metabolic Evaluation
- Effect of Growth Hormone Treatment on Hypoglycemia in a Patient with both Hepatic Glycogen Synthase and Isolated Growth Hormone Deficiencies
- Gliclazide-Induced Hepatitis, Hemiplegia and Dysphasia in a Suicide Attempt
- Neonatal Goiter Caused by Expectorant Usage
- Idiopathic Hypothalamic Dysfunction with Precocious Puberty and Adipsic Hypernatremia First Presenting in Adolescence
- Neonatal Hyperthyroidism m Infants of Mothers Previously Thyroidectomized due to Graves’ Disease
- Primary Hyperparathyroidism in an Infant with Three Parathyroid Glands and Pulmonary Calcinosis
- Asymmetric Crying Facies and Congenital Hypothyroidism: Report of Two Patients
- Obituary. Professor Dr. Andrea Prader (1919–2001)
- Meetings Calendar
- Author Index
Artikel in diesem Heft
- Titelei
- Table of Contents
- Doping with Growth Hormone
- Intrauterine Diabetic Environment Confers Risks for Type 2 Diabetes Mellitus and Obesity in the Offspring, in Addition to Genetic Susceptibility
- Variable Presentation of X-linked Adrenal Hypoplasia Congenita
- Sustained Benefits of Growth Hormone on Body Composition, Fat Utilization, Physical Strength and Agility, and Growth in Prader-Willi Syndrome are Dose-Dependent
- Insufficient Adrenarche in Patients with Combined Pituitary Hormone Deficiency Caused by a PROP A Gene Defect
- Syndrome of Congenital Adrenocortical Unresponsiveness to ACTH. Report of Six Patients
- Maternal and Fetal Serum Insulin-like Growth Factor-I (IGF-I), IGF Binding Protein-3 (IGFBP-3), Leptin Levels and Early Postnatal Growth in Infants Born Asymmetrically Small for Gestational Age
- Relationships Between Levels of Leptin and Hematological Parameters in Healthy Term Infants
- Recombinant Growth Hormone Treatment in Short Patients with Thalassemia Major: Results after 24 and 36 Months
- Assessment of the Current Status of Iodine Prophylaxis in Bosnia and Herzegovina Federation
- Profiles of Obese Children Presenting for Metabolic Evaluation
- Effect of Growth Hormone Treatment on Hypoglycemia in a Patient with both Hepatic Glycogen Synthase and Isolated Growth Hormone Deficiencies
- Gliclazide-Induced Hepatitis, Hemiplegia and Dysphasia in a Suicide Attempt
- Neonatal Goiter Caused by Expectorant Usage
- Idiopathic Hypothalamic Dysfunction with Precocious Puberty and Adipsic Hypernatremia First Presenting in Adolescence
- Neonatal Hyperthyroidism m Infants of Mothers Previously Thyroidectomized due to Graves’ Disease
- Primary Hyperparathyroidism in an Infant with Three Parathyroid Glands and Pulmonary Calcinosis
- Asymmetric Crying Facies and Congenital Hypothyroidism: Report of Two Patients
- Obituary. Professor Dr. Andrea Prader (1919–2001)
- Meetings Calendar
- Author Index
