References

[1] Sellamuthu PS, Arulselvan P, Muniappan BP, Fakurazi S, Kandasamy M. Mangiferin from salacia Chinensis prevents oxidative stress and protects pancreatic b-cells in streptozotocin-induced diabetic rats. J Med Food 2013;16:719–27.10.1089/jmf.2012.2480Suche in Google Scholar PubMed

[2] Askary-Ashtiani A, Ghanjal A, Motaqi M, Meftahi GH, Hatef B, Niknam H. The isokinetic and electromyographic assessment of knee muscles strength in the short- and long-term type 2 diabetes. Asian J Sports Med 2016;7:e37008.10.5812/asjsm.37008Suche in Google Scholar PubMed PubMed Central

[3] Kim SH, Hyun SH, Choung SY. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol 2006;104:119–23.10.1016/j.jep.2005.08.059Suche in Google Scholar PubMed

[4] Samarghandian S, Azimi-Nezhad M, Farkhondeh T. Immunomodulatory and antioxidant effects of saffron aqueous extract (Crocus sativus L.) on streptozotocin-induced diabetes in rats. IHJ 2017;69:151–9.10.1016/j.ihj.2016.09.008Suche in Google Scholar PubMed PubMed Central

[5] Matough FA, Budin SB, Hamid ZA, Alwahaibi N, Mohamed J. The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos Univ Med J 2012;12:5–18.10.12816/0003082Suche in Google Scholar PubMed PubMed Central

[6] Volpe CM, Villar-Delfino PH, Dos Anjos PMF, Nogueira-Machado JA. Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis 2018;9:119.10.1038/s41419-017-0135-zSuche in Google Scholar PubMed PubMed Central

[7] Sellamuthu PS, Arulselvan P, Kamalraj S, Fakurazi S, Kandasamy M. Protective nature of mangiferin on oxidative stress and antioxidant status in tissues of streptozotocin-induced diabetic rats. ISRN Pharmacol 2013;2013:750109.10.1155/2013/750109Suche in Google Scholar PubMed PubMed Central

[8] Mohamed AK, Bierhaus A, Schiekofer S, Tritschler H, Ziegler R, Nawroth PP. The role of oxidative stress and NF-κB activation in late diabetic complications. BioFactors 1999;10:157–67.10.1002/biof.5520100211Suche in Google Scholar PubMed

[9] Del Turco S, Basta G. An update on advanced glycation endproducts and atherosclerosis. Biofactors 2012;38:266–74.10.1002/biof.1018Suche in Google Scholar PubMed

[10] Nowotny K, Jung T, Hohn A, Weber D, Grune T. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules 2015;5:194–222.10.3390/biom5010194Suche in Google Scholar PubMed PubMed Central

[11] Yuan T, Yang T, Chen H, Fu D, Hu Y, Wang J, et al. New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis. Redox Biol 2019;20:247–60.10.1016/j.redox.2018.09.025Suche in Google Scholar PubMed PubMed Central

[12] Schleicher E, Friess U. Oxidative stress, AGE, and atherosclerosis. Kidney Int 2007;106:S17–S26.10.1038/sj.ki.5002382Suche in Google Scholar PubMed

[13] Lubrano V, Balzan S. LOX-1 and ROS, inseparable factors in the process of endothelial damage. Free Radic Res 2014;48:841–8.10.3109/10715762.2014.929122Suche in Google Scholar PubMed

[14] Kita T, Kume N, Minami M, Hayashida K, Murayama T, Sano H, et al. Role of oxidized LDL in atherosclerosis. Ann N Y Acad Sci 2001;947:199–205.10.1111/j.1749-6632.2001.tb03941.xSuche in Google Scholar PubMed

[15] Hashtjini MM, Jahromi GP, Meftahi GH. Aqueous extract of saffron administration along with amygdala deep brain stimulation promoted alleviation of symptoms in post-traumatic stress disorder (PTSD) in rats. Avicenna J Phytomed 2018;8:358–69.Suche in Google Scholar

[16] Ghodrat M, Sahraei H, Razjouyan J, Meftahi GH. Effects of a saffron alcoholic extract on visual short-term memory in humans: a psychophysical study. Neurophysiology 2014;46:247–53.10.1007/s11062-014-9436-3Suche in Google Scholar

[17] Hadipour M, Kaka G, Bahrami F, Meftahi GH, Pirzad Jahromi G, Mohammadi A, et al. Crocin improved amyloid beta induced long-term potentiation and memory deficits in the hippocampal CA1 neurons in freely moving rats. Synapse 2018;72:e22026.10.1002/syn.22026Suche in Google Scholar PubMed

[18] Shirali S, Bathaie Z, Nakhjavani M. Effect of crocin on the insulin resistance and lipid profile of streptozotocin-induced diabetic rats. Phytother Res 2013;27:1042–7.10.1002/ptr.4836Suche in Google Scholar PubMed

[19] Rajaei Z, Hadjzadeh MA, Nemati H, Hosseini M, Ahmadi M, Shafiee S. Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats. J Med Food 2013;16:206–10.10.1089/jmf.2012.2407Suche in Google Scholar PubMed

[20] Yaribeygi H, Sahraei H, Mohammadi AR, Meftahi GH. Saffron (Crocus sativus L.) and morphine dependence: A systematic review article. A J B L S 2014;2:41–5.Suche in Google Scholar

[21] Asalgoo S, Jahromi GP, Hatef B, Sahraei H, Sarshoori J, Sadr S, et al. Saffron (Crocus sativus) aqueous extract reverses the hypothalamus-pituitary-adrenal axis activity in rat model of post-traumatic stress disorder. Rev Bras Farmacogn 2019;29:470–6.10.1016/j.bjp.2019.01.011Suche in Google Scholar

[22] Yaribeygi H, Mohammadi MT, Sahebkar A. Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats. Biomed Pharmacother 2018;98:333–7.10.1016/j.biopha.2017.12.077Suche in Google Scholar PubMed

[23] Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, et al. An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med 2018;8:361–76.10.1016/j.jtcme.2017.08.012Suche in Google Scholar PubMed PubMed Central

[24] Moradi B, Abbaszadeh S, Shahsavari S, Alizadeh M, Beyranvand F. The most useful medicinal herbs to treat diabetes. Biomed Res Ther 2018;5:2538–51.10.15419/bmrat.v5i8.463Suche in Google Scholar

[25] King A. The use of animal models in diabetes research. Br J Pharmacol 2012;166:877–94.10.1111/j.1476-5381.2012.01911.xSuche in Google Scholar PubMed PubMed Central

[26] Skovso S. Modeling type 2 diabetes in rats using high fat diet and streptozotocin. J Diabetes Invest 2014;5:349–58.10.1111/jdi.12235Suche in Google Scholar PubMed PubMed Central

[27] Dogukan A, Sahin N, Tuzcu M, Juturu V, Orhan C, Onderci M, et al. The effects of chromium histidinate on mineral status of serum and tissue in fat-fed and streptozotocin-treated type II diabetic rats. Biol Trace Elem Res 2009;131:124–32.10.1007/s12011-009-8351-8Suche in Google Scholar PubMed

[28] Suman RK, Mohanty IR, Borde MK, Maheshwari U, Deshmukh YA. Development of an experimental model of diabetes co-existing with metabolic syndrome in rats. Adv Pharmacol Sci 2016;2016:11. Article ID 9463476.10.1155/2016/9463476Suche in Google Scholar PubMed PubMed Central

[29] Pirmoradi L, Mohammadi MT, Safaei A, Mesbah F, Dehghani GA. Does the relief of glucose toxicity act as a mediator in proliferative actions of vanadium on pancreatic islet beta cells in streptozocin diabetic rats? IBJ 2014;18:173–80.Suche in Google Scholar

[30] Mohammadi MT, Pirmoradi L, Mesbah F, Safaee A, Dehghani GA. Trophic actions of oral vanadium and improved glycemia on the pancreatic beta-cell ultrastructure of streptozotocin-induced diabetic rats. JOP 2014;15:591–6.Suche in Google Scholar

[31] Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Gadbois TM, et al. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism 2000;49:1390–4.10.1053/meta.2000.17721Suche in Google Scholar PubMed

[32] Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocintreated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res 2005;52:313–20.10.1016/j.phrs.2005.05.004Suche in Google Scholar PubMed

[33] Hazman O, Aksoy L, Buyukben A. Effects of crocin on experimental obesity and type-2 diabetes. Turk J Med Sci 2016;46:1593–602.10.3906/sag-1506-108Suche in Google Scholar PubMed

[34] Zlatkis A, Zac B, Boyle AJ. A new method for the direct determination of serum cholesterol. J Lab Clin Med 1953;41:486–92.Suche in Google Scholar

[35] Riahi S, Mohammadi MT, Sobhani V, Ababzadeh S. Chronic aerobic exercise decreases lectin-like low density lipoprotein (LOX-1) receptor expression in heart of diabetic rat. Iran Biomed J 2016;20:26–32.Suche in Google Scholar

[36] Hudson BI, Wendt T, Bucciarelli LG, Rong LL, Naka Y, Yan S, et al. Diabetic vascular disease: it’s all the RAGE. Antioxid Redox Signal 2005;7:1588–600.10.1089/ars.2005.7.1588Suche in Google Scholar PubMed

[37] Gupta S, Kataria M, Gupta PK, Murganandan S, Yashroy RC. Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats. J Ethnopharmacol 2004;90:185–9.10.1016/j.jep.2003.09.024Suche in Google Scholar

[38] Shirali S, Bathaie Z, Nakhjavani M. Effect of Crocin on the insulin resistance and lipid profile of streptozotocin-induced diabetic rats. Phytother Res 2012;27:1042–7.10.1002/ptr.4836Suche in Google Scholar

[39] Sheng L, Qian Z, Zheng S, Xi L. Mechanism of hypolipidemic effect of crocin in rats: Crocin inhibits pancreatic lipase. Eur J Pharmacol 2006;543:116–22.10.1016/j.ejphar.2006.05.038Suche in Google Scholar

[40] Huggins KW, Camarota LM, Howles PN, Hui DY. Pancreatic lipase deficiency minimally affects dietary fat absorption but dramatically decreases dietary cholesterol absorption in mice. J Biol Chem 2003;278:42899–905.10.1074/jbc.M303422200Suche in Google Scholar

[41] Sharma S, Nasir A, Parbhu K, Mursy B, Dev G. Hypoglycemic and hypolipidemic effect of etanolic extract of seeds in alloxan induced diabetic rabbits. J Ethnopharmacol 2003;85:201–6.10.1016/S0378-8741(02)00366-5Suche in Google Scholar

[42] Mohajeri D, Tabrizi BA, Mousavi G, Mesgari M. Anti-diabetic activity of Crocus sativus L. (Saffron) stigma ethanolic extract in alloxan-induced diabetic rats. Res J Biol Sci 2008;3:1102–8.Suche in Google Scholar

[43] Chen M, Nagase M, Fujita T, Narumiya S, Masaki T, Sawamura T. Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE. Biochem Biophys Res Commun 2001;287:962–8.10.1006/bbrc.2001.5674Suche in Google Scholar PubMed

[44] Bierhaus A, Hofmann MA, Ziegler R, Nawroth PP. AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I Age Concept Circ Res 1998;37:586–600.10.1016/S0008-6363(97)00233-2Suche in Google Scholar