Abstract
Dietary antioxidants are widely distributed in various types of our food. They are strongly associated with reduced risk of many chronic diseases such as atherosclerosis, cancer, and Alzheimer’s diseases. They include vitamins such as vitamins A, E, C, and carotenoids. Also, some minerals like; zinc, manganese, copper, iron, and selenium are essential for the activity of antioxidant enzymes. Furthermore, dietary polyphenols and flavonoids are considered as potent antioxidant compounds. Vegetables, fruits, and edible herbs are the richest sources of such antioxidants. Antioxidants reduce oxidative stress, either directly by reducing reactive species or indirectly by enhancing the body antioxidant defense mechanisms in different ways. These may include upregulating gene expression of some antioxidant enzymes via a nuclear factor erythroid 2 related factor2 pathway. Administration of a mixture of antioxidants is beneficial since they act synergistically in various phases. The aims of this review are to summarize the different antioxidants from dietary sources and their role in the prevention of different diseases.
Author contributions: AH and AA put the primary idea of the article and participated in collecting data. EM and KS modified the idea of the article, collecting data, writing, reviewing, and editing. All authors read and approved the final manuscript.
Novelty and contribution of this work: The link between the antioxidants and diseases is still poorly understood. therefore we tried to clarify the role of such antioxidants in various diseases. Also, we focused on their function in the induction of the nuclear factor erythroid 2 related factor2 by screening various review.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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- Pre-clinical studies
- Assessment of compliance level of ICH guidelines for organic volatile impurities in common ayurvedic hepatic formulations
- Nephroprotective properties of the methanol stem extract of Abrus precatorius on gentamicin-induced renal damage in rats
- Phytochemical analysis, cytotoxic and antioxidant activities of Myrtus communis essential oil from Morocco
- In vitro and in vivo toxicity assessment of biologically synthesized silver nanoparticles from Elaeodendron croceum
- Evaluation of in-vitro and in-vivo antidiabetic, antilipidemic and antioxidant potentials of aqueous root extract of Strophanthus hispidus DC (Apocynaceae)
- Clinical studies
- Effects of acupuncture on chronic idiopathic pruritus: an uncontrolled pilot study evaluating inflammatory changes with treatment
- Medicinal plants’ use among patients with dyslipidemia: an Iranian cross-sectional survey
- Music to reduce pain and anxiety in cystoscopy: a systematic review and meta-analysis
- Fenugreek dermal patch, a new natural topical antinociceptive medication for relieving the postherniotomy pain, a double-blind placebo controlled trial
- Evaluating the effect of lifestyle education based on peer model on anxiety in patients with acute myocardial infarction
- The effects of a Melissa officinalis L. based product on metabolic parameters in patients with type 2 diabetes mellitus: A randomized double-blinded controlled clinical trial
- Comparison of the effects of nature sounds and reflexology on hemodynamic indices among traumatic comatose patients: A randomized controlled clinical trial
- Short Communication
- Use of natural remedies to treat oral diseases among female patients in Al Madinah, western Saudi Arabia
- Case report
- An integrated approach for the management of diabetic foot ulcer: a case report
Articles in the same Issue
- Review
- A review on traditional practice of tooth brushing in Ayurveda and its relevance in current era
- Dietary antioxidant for disease prevention corroborated by the Nrf2 pathway
- Mini Review
- Effects of dietary supplementations and herbs on migraine – a systematic review
- Pre-clinical studies
- Assessment of compliance level of ICH guidelines for organic volatile impurities in common ayurvedic hepatic formulations
- Nephroprotective properties of the methanol stem extract of Abrus precatorius on gentamicin-induced renal damage in rats
- Phytochemical analysis, cytotoxic and antioxidant activities of Myrtus communis essential oil from Morocco
- In vitro and in vivo toxicity assessment of biologically synthesized silver nanoparticles from Elaeodendron croceum
- Evaluation of in-vitro and in-vivo antidiabetic, antilipidemic and antioxidant potentials of aqueous root extract of Strophanthus hispidus DC (Apocynaceae)
- Clinical studies
- Effects of acupuncture on chronic idiopathic pruritus: an uncontrolled pilot study evaluating inflammatory changes with treatment
- Medicinal plants’ use among patients with dyslipidemia: an Iranian cross-sectional survey
- Music to reduce pain and anxiety in cystoscopy: a systematic review and meta-analysis
- Fenugreek dermal patch, a new natural topical antinociceptive medication for relieving the postherniotomy pain, a double-blind placebo controlled trial
- Evaluating the effect of lifestyle education based on peer model on anxiety in patients with acute myocardial infarction
- The effects of a Melissa officinalis L. based product on metabolic parameters in patients with type 2 diabetes mellitus: A randomized double-blinded controlled clinical trial
- Comparison of the effects of nature sounds and reflexology on hemodynamic indices among traumatic comatose patients: A randomized controlled clinical trial
- Short Communication
- Use of natural remedies to treat oral diseases among female patients in Al Madinah, western Saudi Arabia
- Case report
- An integrated approach for the management of diabetic foot ulcer: a case report