Effects of quinine on gastric ulcer healing in Wistar rats
-
Olasupo Stephen Adeniyi
,
Olubiyi Vincent Makinde
Abstract
Background
Quinine (QT) is an important anti-malarial drug; however, there is little information about its effects on the gut. Therefore, this study aimed to investigate the effects of a therapeutic dose of QT on the healing of gastric ulcer in rats.
Methods
Male Wistar rats weighing 150–200 g were divided into three groups: control rats without ulcer (group 1), ulcerated rats treated with 1 mL/kg (p.o.) normal saline (NS) (group 2), and ulcerated rats treated with 10 mg/kg (p.o.) QT (group 3). Ulcers were induced by serosal application of 80 % acetic acid to the stomach of rats anaesthetized with 50 mg/kg thiopentone sodium and treatment was given three times daily. Healing was assessed on days 3, 7 and 10 after ulcer induction by macroscopic measurement of: ulcer area, histology, lipid peroxidation, superoxide dismutase activity and gastric mucus secretion.
Results
At day 3, there was no significant difference (p>0.05) in ulcer areas between NS- and QT-treated rats. By day 10, however, the percentage area healed in NS treated (59.6±2.35 %) was significantly higher (p<0.05) than in QT rats (49.0±2.20 %) and clearing of inflammatory cells and re-epithelization was greater in NS-treated group. By days 7 and 10, lipid peroxidation was significantly higher in QT animals, when compared with NS-treated rats and controls (p<0.05). Superoxide dismutase activity and mucus secretion were significantly (p<0.05) higher in NS-treated than QT-treated rats.
Conclusions
QT delayed ulcer healing by prolonging the inflammatory phase of healing, increasing oxidative stress, reducing antioxidant activity and gastric mucus secretion
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Articles in the same Issue
- Review
- Effect of ginseng therapy on diabetes and its chronic complications: lessons learned
- Preclinical Studies
- Antioxidant and acetylcholinesterase inhibitory activities of ginger root (Zingiber officinale Roscoe) extract
- Evaluation of hepatic glycogen content, some haematological and biochemical parameters of alloxan-induced diabetic rats treated with combinations of glibenclamide and G. latifolium extract
- Ameliorative role of ethyl-acetate fraction of methanolic leaf extract of Camellia sinensis (green tea) on streptozotocin-induced diabetes linked testicular hypofunction in albino rat: A dose-dependent biochemical and genomic transection study
- Effects of quinine on gastric ulcer healing in Wistar rats
- Hypocholesterolemic activity of cornelian cherry (Cornus mas L.) fruits
- Phytochemical analysis of Myrtus communis plant: Conventional versus microwave assisted-extraction procedures
- Effects of pomegranate peel extract on histopathology, testosterone levels and sperm of testicular torsion–detorsion induced in adult Wistar rats
- Mechanism of antihypertensive effect of Mucuna pruriens L. seed extract and its isolated compounds
- Antioxidant capacity and phenolic content of two Algerian Mentha species M. rotundifolia (L.) Huds, M. pulegium L., extracted with different solvents
- Case Report
- An innovative mindfulness and educational care approach in an adult patient affected by gastroesophageal reflux: the IARA model
Articles in the same Issue
- Review
- Effect of ginseng therapy on diabetes and its chronic complications: lessons learned
- Preclinical Studies
- Antioxidant and acetylcholinesterase inhibitory activities of ginger root (Zingiber officinale Roscoe) extract
- Evaluation of hepatic glycogen content, some haematological and biochemical parameters of alloxan-induced diabetic rats treated with combinations of glibenclamide and G. latifolium extract
- Ameliorative role of ethyl-acetate fraction of methanolic leaf extract of Camellia sinensis (green tea) on streptozotocin-induced diabetes linked testicular hypofunction in albino rat: A dose-dependent biochemical and genomic transection study
- Effects of quinine on gastric ulcer healing in Wistar rats
- Hypocholesterolemic activity of cornelian cherry (Cornus mas L.) fruits
- Phytochemical analysis of Myrtus communis plant: Conventional versus microwave assisted-extraction procedures
- Effects of pomegranate peel extract on histopathology, testosterone levels and sperm of testicular torsion–detorsion induced in adult Wistar rats
- Mechanism of antihypertensive effect of Mucuna pruriens L. seed extract and its isolated compounds
- Antioxidant capacity and phenolic content of two Algerian Mentha species M. rotundifolia (L.) Huds, M. pulegium L., extracted with different solvents
- Case Report
- An innovative mindfulness and educational care approach in an adult patient affected by gastroesophageal reflux: the IARA model
