Abstract
Postmenopausal osteoporosis, a silent epidemic, has become a major health hazard, afflicting about 50% of postmenopausal women worldwide and is thought to be a disease with one of the highest incidences in senile people. It is a chronic, progressive condition associated with micro-architectural deterioration of bone tissue that results in low bone mass, decreased bone strength that predisposes to an increased risk of fracture. Women are more likely to develop osteoporosis than men due to reduction in estrogen during menopause which leads to decline in bone formation and increase in bone resorption activity. Estrogen is able to suppress the production of proinflammatory cytokines like interleukin (IL)-1, IL-6, IL-7 and tumor necrosis factor (TNF-α). This is why these cytokines are elevated in postmenopausal women. In this review article we have made an attempt to collate the various methods and parameters most frequently used for screening of antiosteoporotic activity in postmenopausal osteoporosis. Pertaining to ovariectomized animal model, this is the most appropriate model for studying the efficacy of different drugs to prevent bone loss in postmenopausal osteoporosis.
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©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Review
- Experimental techniques for screening of antiosteoporotic activity in postmenopausal osteoporosis
- Preclinical Studies
- Immunomodulatory activity of methanol leaf extracts of Cameroonian medicinal plants
- Dietary supplementation with green tea extract promotes enhanced human leukocyte activity
- Newtonoate as an active principle of Newtonia griffoniana for anxiolytic activity in Swiss mice
- Antibacterial activity of combination of synthetic and biopolymer non-woven structures
- Amelioration of chronic inflammation and oxidative stress indices in diabetic Wistar rats using methanol leaf extract of Bridelia micrantha (Hochst) Baill. (Euphorbiaceae)
- Possible anti-diarrhoeal potential of ethanol leaf extract of Chromolaena odorata in castor oil-induced rats
- Inhibition of AKT signaling by supercritical CO2 extract of mango ginger (Curcuma amada Roxb.) in human glioblastoma cells
- Clinical Studies
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- Assessment of the impacts of traditional Persian medical schemes and recommendations on functional chronic constipation compared to a classic medicine lactulose, a randomized clinical trial
Articles in the same Issue
- Frontmatter
- Review
- Experimental techniques for screening of antiosteoporotic activity in postmenopausal osteoporosis
- Preclinical Studies
- Immunomodulatory activity of methanol leaf extracts of Cameroonian medicinal plants
- Dietary supplementation with green tea extract promotes enhanced human leukocyte activity
- Newtonoate as an active principle of Newtonia griffoniana for anxiolytic activity in Swiss mice
- Antibacterial activity of combination of synthetic and biopolymer non-woven structures
- Amelioration of chronic inflammation and oxidative stress indices in diabetic Wistar rats using methanol leaf extract of Bridelia micrantha (Hochst) Baill. (Euphorbiaceae)
- Possible anti-diarrhoeal potential of ethanol leaf extract of Chromolaena odorata in castor oil-induced rats
- Inhibition of AKT signaling by supercritical CO2 extract of mango ginger (Curcuma amada Roxb.) in human glioblastoma cells
- Clinical Studies
- A cross-sectional study on knowledge and attitude toward Traditional Chinese Medicine (TCM) among adults in selected regions of Malaysia
- Assessment of the impacts of traditional Persian medical schemes and recommendations on functional chronic constipation compared to a classic medicine lactulose, a randomized clinical trial