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Efficacy of flower pollen extract with vitamins in improving urinary and sexual function in patients with chronic prostatitis: a retrospective study

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Veröffentlicht/Copyright: 25. Dezember 2025
Journal of Basic and Clinical Physiology and Pharmacology
Aus der Zeitschrift Journal of Basic and Clinical Physiology and Pharmacology

Abstract

Objectives

To assess the efficacy and safety of Flower Pollen Extract with Vitamins (PEV) in improving urinary and sexual function in men diagnosed with chronic prostatitis (CP).

Methods

A retrospective controlled study was conducted involving 145 men with CP. Participants were divided into two groups: the intervention group received PEV (n=71) and the control group received ibuprofen (n=74). Clinical and functional outcomes were evaluated at baseline and at 1, 3, and 12 months post-treatment.

Results

Both groups exhibited comparable baseline characteristics. At 3 months, the PEV group demonstrated significantly greater improvement in IPSS (9.4 ± 2.7 vs. 10.3 ± 2.6, p=0.04), NIH-CPSI (11.5 ± 3.7 vs. 13.6 ± 4.2, p=0.002), and IIEF-5 (19.8 ± 3.6 vs. 17.7 ± 3.3, p<0.001). These benefits were maintained and further enhanced at 12 months, with mean IPSS 7.6 ± 2.1, NIH-CPSI 6.5 ± 2.4, and IIEF-5 21.6 ± 3.3 in the PEV group (all p<0.005). No significant differences were observed in Qmax.

Conclusions

Long-term PEV therapy significantly improves urinary and sexual function in men with CP compared with ibuprofen treatment, demonstrating sustained, time-dependent efficacy and excellent safety.

Keywords: chronic prostatitis; flower pollen extract; lower urinary tract symptoms; erectile dysfunction; phytotherapy
Corresponding author: Carlo Giulioni, Department of Urology, Casa di Cura Villa Igea, 60127, Ancona, Italy, E-mail:

Acknowledgments

CG: project development, manuscript writing, and data collection. FF: data collection. VM: data collection and analysis. FC: manuscript editing. AC: project development and manuscript editing.

  1. Research ethics: Not applicable.

  2. Informed consent: Written informed consent was obtained from all participants for the collection and anonymized analysis of their clinical data.

  3. Author contributions: CG: project development, manuscript writing, and data collection. FF: data collection. VM: data collection and analysis. FC: manuscript editing. AC: project development and manuscript editing.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: Authors state no conflict of interest.

  6. Research funding: Not applicable.

  7. Data availability: The dataset used in this study is available upon request from the corresponding author.

References

1. Collins, MM, Stafford, RS, O’Leary, MP, Barry, MJ. How common is prostatitis? A national survey of physician visits. J Urol 1998;159:1224–8. https://doi.org/10.1097/00005392-199804000-00037.Suche in Google Scholar

2. Su, ZT, Zenilman, JM, Sfanos, KS, Herati, AS. Management of chronic bacterial prostatitis. Curr Urol Rep 2020;21:29. https://doi.org/10.1007/s11934-020-00978-z.Suche in Google Scholar PubMed

3. Giulioni, C, Tallè, M, Papaveri, A, Mengoni, F, Orciani, R, Pandolfo, SD, et al.. The implementation of trifecta score to assess the quality of holmium laser enucleation of the prostate in elderly patients: an analysis of perioperative and functional outcomes and the impact of age. J Clin Med 2025;14:3410. https://doi.org/10.3390/jcm14103410.Suche in Google Scholar PubMed PubMed Central

4. Lee, JH, Lee, SW. Relationship between premature ejaculation and chronic prostatitis/chronic pelvic pain syndrome. J Sex Med 2015;12:697–704. https://doi.org/10.1111/jsm.12796.Suche in Google Scholar PubMed

5. Palumbo, S, Lucarelli, G, Lasorsa, F, Damiano, R, Autorino, R, Aveta, A, et al.. Urobiome and inflammation: a systematic review on microbial imbalances and diagnostic tools for urinary disorders. Urology 2025;200:206–15. https://doi.org/10.1016/j.urology.2025.03.050.Suche in Google Scholar PubMed

6. Gauhar, V, Giulioni, C, Gadzhiev, N, De Stefano, V, Teoh, JY, Tiong, HY, et al.. Na update of in vivo application of artificial intelligence and robotics for percutaneous nephrolithotripsy: results from a systematic review. Curr Urol Rep 2023;24:271–80. https://doi.org/10.1007/s11934-023-01155-8.Suche in Google Scholar PubMed

7. Yang, JX, Wang, HF, Chen, JZ, Li, HY, Hu, JC, Yu, AA, et al.. Potential neuroimmune interaction in chronic pain: a review on immune cells in peripheral and central sensitization. Front Pain Res (Lausanne) 2022;3:946846. https://doi.org/10.3389/fpain.2022.946846.Suche in Google Scholar PubMed PubMed Central

8. Pena, VN, Engel, N, Gabrielson, AT, Rabinowitz, MJ, Herati, AS. Diagnostic and management strategies for patients with chronic prostatitis and chronic pelvic pain syndrome. Drugs Aging 2021;38:845–86. https://doi.org/10.1007/s40266-021-00890-2.Suche in Google Scholar PubMed

9. Pirola, GM, Castellani, D, Naselli, A, Fong, KY, Biligere, S, Dellabella, M, et al.. Endoscopic enucleation of the prostate in men aged 80 years and older. Outcomes from a global, large, and multicenter series using different energy sources and techniques. World J Urol 2025;43:344. https://doi.org/10.1007/s00345-025-05699-x.Suche in Google Scholar PubMed

10. Bartoletti, R, Cai, T, Mondaini, N, Dinelli, N, Pinzi, N, Pavone, C, et al.. Prevalence, incidence estimation, risk factors and characterization of chronic prostatitis/chronic pelvic pain syndrome in urological hospital outpatients in Italy: results of a multicenter case-control observational study. J Urol 2007;178:2411–5. https://doi.org/10.1016/j.juro.2007.08.046.Suche in Google Scholar PubMed

11. Qin, Z, Zhang, C, Guo, J, Kwong, JSW, Li, X, Pang, R, et al.. Oral pharmacological treatments for chronic prostatitis/chronic pelvic pain syndrome: a systematic review and network meta-analysis of randomised controlled trials. eClinicalMedicine 2022;48:101457. https://doi.org/10.1016/j.eclinm.2022.101457.Suche in Google Scholar PubMed PubMed Central

12. Cai, T, Verze, P, La Rocca, R, Palmieri, A, Tiscione, D, Luciani, LG, et al.. The clinical efficacy of pollen extract and vitamins on chronic prostatitis/chronic pelvic pain syndrome is linked to a decrease in the pro-inflammatory cytokine Interleukin-8. World J Mens Health 2017;35:120–8. https://doi.org/10.5534/wjmh.2017.35.2.120.Suche in Google Scholar PubMed PubMed Central

13. Manfredi, C, Calace, FP, Fusco, F, Quattrone, C, Giordano, D, Crocetto, F, et al.. Escherichia coli Nissle 1917 as adjuvant therapy in patients with chronic bacterial prostatitis: a non-blinded, randomized, controlled trial. World J Urol 2021;39:4373–9. https://doi.org/10.1007/s00345-021-03773-8.Suche in Google Scholar PubMed

14. Nickel, JC, Downey, J, Clark, J, Casey, RW, Pommerville, PJ, Barkin, J, et al.. Levofloxacin for chronic prostatitis/chronic pelvic pain syndrome in men: a randomized placebo-controlled multicenter trial. Urology 2003;62:614–7. https://doi.org/10.1016/s0090-4295(03)00583-1.Suche in Google Scholar PubMed

15. Tallè, M, Giulioni, C, Papaveri, A, Mengoni, F, Orciani, R, Pandolfo, SD, et al.. Influence of preoperative indwelling urinary catheter on outcomes of high-power holmium laser enucleation for very large prostate (≥200 mL). World J Urol 2025;43:223. https://doi.org/10.1007/s00345-025-05624-2.Suche in Google Scholar PubMed

16. Scarcella, S, Castellani, D, Gauhar, V, Teoh, JY, Giulioni, C, Piazza, P, et al.. Robotic-assisted versus open simple prostatectomy: results from a systematic review and meta-analysis of comparative studies. Investig Clin Urol 2021;62:631–40. https://doi.org/10.4111/icu.20210297.Suche in Google Scholar PubMed PubMed Central

17. Giulioni, C, Falsetti, F, Tallè, M, Papaveri, A, Mengoni, F, Orciani, R, et al.. Impact of preoperative catheter duration on perioperative safety and functional outcomes following holmium laser enucleation of the prostate for benign prostatic hyperplasia: results from a single-center series. Low Urin Tract Symptoms 2025;17:e70039. https://doi.org/10.1111/luts.70039.Suche in Google Scholar PubMed

18. Castellani, D, Yuen, SK, Giulioni, C, Fong, KY, Doizi, S, Moretto, S, et al.. To stop or not to stop. Endoscopic enucleation of the prostate in patients on blood thinners: outcomes, a real-life prospective multicenter study of 932 cases. World J Urol 2025;43:674. https://doi.org/10.1007/s00345-025-06072-8.Suche in Google Scholar PubMed

19. Barone, B, Mirto, BF, Falcone, A, Del Giudice, F, Aveta, A, Napolitano, L, et al.. The efficacy of flogofilm® in the treatment of chronic bacterial prostatitis as an adjuvant to antibiotic therapy: a randomized prospective trial. J Clin Med 2023;12:2784. https://doi.org/10.3390/jcm12082784.Suche in Google Scholar PubMed PubMed Central

20. Cai, T, Luciani, LG, Caola, I, Mondaini, N, Malossini, G, Lanzafame, P, et al.. Effects of pollen extract in association with vitamins (DEPROX 500®) for pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome: results from a pilot study. Urologia 2013;80:5–10. https://doi.org/10.5301/ru.2013.10597.Suche in Google Scholar PubMed

21. Wagenlehner, FM, Bschleipfer, T, Pilatz, A, Weidner, W. Pollen extract for chronic prostatitis-chronic pelvic pain syndrome. Urol Clin 2011;38:285–92. https://doi.org/10.1016/j.ucl.2011.04.004.Suche in Google Scholar PubMed

22. Rugendorff, EW, Weidner, W, Ebeling, L, Buck, AC. Results of treatment with pollen extract (Cernilton N) in chronic prostatitis and prostatodynia. Br J Urol 1993;71:433–8. https://doi.org/10.1111/j.1464-410x.1993.tb15988.x.Suche in Google Scholar PubMed

23. MacDonald, R, Ishani, A, Rutks, I, Wilt, TJ. A systematic review of Cernilton for the treatment of benign prostatic hyperplasia. BJU Int 2000;85:836–41. https://doi.org/10.1046/j.1464-410x.2000.00365.x.Suche in Google Scholar PubMed

24. Giulioni, C, Pitoni, L, Fuligni, D, Beltrami, M, Passarella, V, Palantrani, V, et al.. Pudendal nerve neurolysis outcomes for urogenital and rectal disorders in patients suffering from pudendal nerve entrapment: a systematic review. Investig Clin Urol 2024;65:230–9. https://doi.org/10.4111/icu.20230402.Suche in Google Scholar PubMed PubMed Central

25. Giulioni, C, Pirola, GM, Maggi, M, Pitoni, L, Fuligni, D, Beltrami, M, et al.. Pudendal nerve neurolysis in patients afflicted with pudendal nerve entrapment: a systematic review of surgical techniques and their efficacy. Int Neurourol J 2024;28:11–21. https://doi.org/10.5213/inj.2448010.005.Suche in Google Scholar PubMed PubMed Central

26. Al Hashimi, M, Pinggera, GM, Mostafa, T, Rambhatla, A, Hamoda, T, Shah, R, et al.. Regenerative therapy in erectile dysfunction: a survey on current global practice trends and GAF expert recommendations. World J Mens Health 2025;43:359–75. https://doi.org/10.5534/wjmh.240086.Suche in Google Scholar PubMed PubMed Central

27. Gauhar, V, Pirola, GM, Scarcella, S, De Angelis, MV, Giulioni, C, Rubilotta, E, et al.. Nephrostomy tube versus double J ureteral stent in patients with malignant ureteric obstruction. A systematic review and meta-analysis of comparative studies. Int Braz J Urol 2022;48:903–14. https://doi.org/10.1590/S1677-5538.IBJU.2022.0225.Suche in Google Scholar PubMed PubMed Central

28. Sievert, KD, Hennenlotter, J, Dillenburg, T, Toomey, P, Wöllner, J, Zweers, P, et al.. Extended periprostatic nerve distributions on the prostate surface confirmed using diffusion tensor imaging. BJU Int 2019;123:995–1004. https://doi.org/10.1111/bju.14508.Suche in Google Scholar PubMed

29. Agarwal, A, Farkouh, A, Saleh, R, Hamoda, TAA, Salvio, G, Boitrelle, F, et al.. Technical aspects and clinical limitations of sperm DNA fragmentation testing in Male infertility: a global survey, current guidelines, and expert recommendations. World J Mens Health 2024;42:202–15. https://doi.org/10.5534/wjmh.230076.Suche in Google Scholar PubMed PubMed Central

30. Farkouh, A, Agarwal, A, Hamoda, TAA, Kavoussi, P, Saleh, R, Zini, A, et al.. Controversy and consensus on the management of elevated sperm DNA fragmentation in Male infertility: a global survey, current guidelines, and expert recommendations. World J Mens Health 2023;41:809–47. https://doi.org/10.5534/wjmh.230008.Suche in Google Scholar PubMed PubMed Central

31. Giulioni, C, Maurizi, V, Scarcella, S, Di Biase, M, Iacovelli, V, Galosi, AB, et al.. Do environmental and occupational exposure to pyrethroids and organophosphates affect human semen parameters? Results of a systematic review and meta-analysis. Andrologia 2021;53:e14215. https://doi.org/10.1111/and.14215.Suche in Google Scholar PubMed

32. Graziani, A, Grande, G, Martin, M, Ferraioli, G, Colonnello, E, Iafrate, M, et al.. Chronic prostatitis/chronic pain pelvic syndrome and male infertility. Life 2023;13:1700. https://doi.org/10.3390/life13081700.Suche in Google Scholar PubMed PubMed Central

33. Giulioni, C, Falsetti, F, Maurizi, V, Del Giudice, F, Crocetto, F, Imbimbo, C, et al.. The impact of heavy metals exposure on male fertility: a scoping review of human studies. J Basic Clin Physiol Pharmacol 2025;36:129–37. https://doi.org/10.1515/jbcpp-2025-0049.Suche in Google Scholar PubMed

34. Zhang, FX, Chen, X, Niu, DC, Cheng, L, Huang, CS, Liao, M, et al.. Chronic prostatitis/chronic pelvic pain syndrome induces metabolomic changes in expressed prostatic secretions and plasma. Asian J Androl 2025;27:101–12. https://doi.org/10.4103/aja202434.Suche in Google Scholar PubMed PubMed Central

35. Lee, DH, Yu, YD. Multi-pharmacological treatment for young subfertile males with chronic prostatitis/chronic pelvic pain syndrome. Investig Clin Urol 2024;65:567–78. https://doi.org/10.4111/icu.20240191.Suche in Google Scholar PubMed PubMed Central

Received: 2025-11-17
Accepted: 2025-12-09
Published Online: 2025-12-25

© 2025 Walter de Gruyter GmbH, Berlin/Boston

https://doi.org/10.1515/jbcpp-2025-0200
Schlagwörter für diesen Artikel
chronic prostatitis; flower pollen extract; lower urinary tract symptoms; erectile dysfunction; phytotherapy
Heruntergeladen am 14.4.2026 von https://www.degruyterbrill.com/document/doi/10.1515/jbcpp-2025-0200/html
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