Home Medicine A drug utilisation pattern in non-dialysis patients of diabetic nephropathy in a government-run tertiary care hospital in South-Asia
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A drug utilisation pattern in non-dialysis patients of diabetic nephropathy in a government-run tertiary care hospital in South-Asia

  • Rajmohan Seetharaman ORCID logo EMAIL logo , Manjari Advani ORCID logo , Smita Mali ORCID logo and Sudhir Pawar ORCID logo
Published/Copyright: February 27, 2023
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 34 Issue 3

Abstract

Objectives

The objective of the present study was to evaluate the Drug utilisation pattern in patients of diabetic nephropathy (stage 1–4) in a tertiary care hospital in South-Asia.

Methods

A cross-sectional observational study was conducted in the nephrology out-patient-department of a tertiary care hospital in South-Asia. WHO core prescribing, dispensing, and patient care indicators were evaluated, and adverse drug reactions (ADRs) encountered by the patients were analysed for causality, severity, preventability, and outcome.

Results

The most commonly prescribed antidiabetics in diabetic nephropathy patients were insulin (17.42%), followed by metformin (4.66%). Current drugs of choice SGLT-2 inhibitors were prescribed in a lesser frequency than expected. Loop diuretics and calcium channel blockers (CCBs) were the preferred antihypertensives. The use of ACE inhibitors (1.26%) and ARBs (3.45%) for hypertension was restricted to Stage 1 and 2 nephropathy. The patients were on 6.47 drugs on average. 30.70% of drugs were prescribed by generic names, 59.07% of the drugs were prescribed from the national essential drugs list and 34.03% of the prescribed drugs were supplied by the hospital. CTCAE grade 1 (68.60%) and grade 2 (22.09%) ADR severity was the highest.

Conclusions

Prescribing patterns in patients of diabetic nephropathy were adapted from relevant medical evidence, affordability and availability of the drugs. Generic prescribing, availability of drugs and ADR preventability in the hospital have a broad scope for improvement.

Keywords: developing country; diabetic kidney disease; drug use; public hospital
Corresponding author: Dr. Rajmohan Seetharaman, Senior Resident, Department of Pharmacology & Therapeutics, Seth G.S. Medical College and KEM Hospital, Mumbai, 400012, India, Phone: +91 9930216995, E-mail:
Dr. Rajmohan Seetharaman and Dr. Manjari Advani are both First Authors.

Acknowledgements

The authors thank the Department of Nephrology, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, for granting them permission for carrying out the study. The authors also thank Mr. Manish Pawar, Clinical research coordinator and Biostatistician, Department of Pharmacology, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, for reviewing the statistical analysis.

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: Ethical approval was obtained from the Institutional Ethics Committee for Human Research, Lokmanya Tilak Municipal Medical College (IEC-HR-LTMMC) – Approval number: IEC/375/19.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/jbcpp-2023-0003).

Received: 2023-01-03
Accepted: 2023-02-07
Published Online: 2023-02-27

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2023-0003
Keywords for this article
developing country; diabetic kidney disease; drug use; public hospital

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Investigating periprostatic adipose tissue as a driving force of prostate cancer progression: a new source of information for the advancement of targeted therapy in metastatic prostate cancer
  4. Reviews
  5. Pathophysiological effects of cadmium(II) on human health-a critical review
  6. The role of synbiotics in improving inflammatory status in nasopharyngeal carcinoma patients
  7. Anti-ageing effects of FDA-approved medicines: a focused review
  8. Diagnosis and management of uterine fibroids: current trends and future strategies
  9. Importance of moderate-to-vigorous physical activity during the COVID-19 pandemic: a systematic review and meta-analysis
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  16. Antioxidant activity in off and on-pump coronary artery bypass grafting and valve replacement surgery
  17. A drug utilisation pattern in non-dialysis patients of diabetic nephropathy in a government-run tertiary care hospital in South-Asia
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