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Diagnosis and management of uterine fibroids: current trends and future strategies

  • Azaz Ahmad , Manoj Kumar , Nihar Ranjan Bhoi , Badruddeen , Juber Akhtar , Mohammad Irfan Khan , Mohd Ajmal and Mohammad Ahmad ORCID logo EMAIL logo
Published/Copyright: March 30, 2023
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 34 Issue 3

Abstract

Uterine fibroids (UFs), leiomyomas or myomas, are a type of malignancy that affects the smooth muscle of the uterus, and it is most commonly detected in women of reproductive age. Uterine fibroids are benign monoclonal growths that emerge from uterine smooth muscle cells (myometrium) as well as fibroblasts. Uterine fibroid symptoms include abnormal menstrual bleeding leading to anaemia, tiredness, chronic vaginal discharge, and pain during periods. Other symptoms include protrusion of the abdomen, pain during intercourse, dysfunctions of bladder/bowel leading to urinary incontinence/retention, pain, and constipation. It is also associated with reproductive issues like impaired fertility, conceiving complications, and adverse obstetric outcomes. It is the leading cause of gynaecological hospitalisation in the American subcontinent and a common reason for the hysterectomy. Twenty-five percent of the reproductive women experience the symptoms of uterine fibroids, and among them, around 25% require hospitalization due to the severity of the disease. The frequency of the disease remains underestimated as many women stay asymptomatic and symptoms appear gradually; therefore, the condition remains undiagnosed. The exact frequency of uterine fibroids varies depending on the diagnosis, and the population investigated; nonetheless, the incidence of uterine fibroids in reproductive women ranges from 5.4 percent to 77 percent. The uterine fibroid treatment included painkillers, supplementation with iron, vitamin D3, birth control, hormone therapy, gonadotropin-releasing hormone (GnRH) agonists, drugs modulating the estrogen receptors, and surgical removal of the fibroids. However, more research needed at the level of gene to get a keen insight and treat the disease efficiently.

Keywords: cause of fibroids; gynaecological disorders; management of fibroids; uterine fibroids; uterine leiomyomas
Corresponding author: Dr. Mohammad Ahmad, Faculty of Pharmacy, Integral University, Dasauli Kursi Road, Lucknow 226026, India, Phone: +91-7408847578, E-mail:

Acknowledgments

Authors are thankful to Professor S.M. Hasan, Dean Faculty of Pharmacy, Integral University, Lucknow for providing technical support and guidance. Thanks to Dean R&D, Integral University for assigning manuscript communication reference IU/R&D/2022-MCN0001405.

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study. Not Applicable

  5. Ethical approval: The local Institutional Review Board deemed the study exempt from review.

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Received: 2022-08-18
Accepted: 2023-02-25
Published Online: 2023-03-30

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Investigating periprostatic adipose tissue as a driving force of prostate cancer progression: a new source of information for the advancement of targeted therapy in metastatic prostate cancer
  4. Reviews
  5. Pathophysiological effects of cadmium(II) on human health-a critical review
  6. The role of synbiotics in improving inflammatory status in nasopharyngeal carcinoma patients
  7. Anti-ageing effects of FDA-approved medicines: a focused review
  8. Diagnosis and management of uterine fibroids: current trends and future strategies
  9. Importance of moderate-to-vigorous physical activity during the COVID-19 pandemic: a systematic review and meta-analysis
  10. Original Articles
  11. Healthcare workers’ knowledge of evidence-based guidelines for prevention of ventilator-associated pneumonia in Hodeida, Yemen
  12. Comparison of cardiac autonomic function across complete glycaemic spectrum
  13. Prognostic value of heart rate variability in acute coronary syndrome
  14. Insights into the protective capacity of human dental pulp stem cells and its secretome in cisplatin-induced nephrotoxicity: effects on oxidative stress and histological changes
  15. Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice
  16. Antioxidant activity in off and on-pump coronary artery bypass grafting and valve replacement surgery
  17. A drug utilisation pattern in non-dialysis patients of diabetic nephropathy in a government-run tertiary care hospital in South-Asia
  18. Inguinal lymphadenectomy in penile cancer patients: a comparison between open and video endoscopic approach in a multicenter setting
  19. A randomized controlled trial to evaluate the efficacy of electrical vestibular nerve stimulation (VeNS), compared to a sham control for the management of sleep in young adults
  20. Short Communication
  21. The role of Bruton’s kinase inhibitors (BTKi) in accelerated Chronic Lymphocytic Leukemia (a-CLL): a case of successful response to acalabrutinib
  22. Letter to the Editor
  23. A hypothesis that Notopterol may be effective in COVID-19 via JAK/STAT and other signaling pathways
https://doi.org/10.1515/jbcpp-2022-0219
Keywords for this article
cause of fibroids; gynaecological disorders; management of fibroids; uterine fibroids; uterine leiomyomas

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Investigating periprostatic adipose tissue as a driving force of prostate cancer progression: a new source of information for the advancement of targeted therapy in metastatic prostate cancer
  4. Reviews
  5. Pathophysiological effects of cadmium(II) on human health-a critical review
  6. The role of synbiotics in improving inflammatory status in nasopharyngeal carcinoma patients
  7. Anti-ageing effects of FDA-approved medicines: a focused review
  8. Diagnosis and management of uterine fibroids: current trends and future strategies
  9. Importance of moderate-to-vigorous physical activity during the COVID-19 pandemic: a systematic review and meta-analysis
  10. Original Articles
  11. Healthcare workers’ knowledge of evidence-based guidelines for prevention of ventilator-associated pneumonia in Hodeida, Yemen
  12. Comparison of cardiac autonomic function across complete glycaemic spectrum
  13. Prognostic value of heart rate variability in acute coronary syndrome
  14. Insights into the protective capacity of human dental pulp stem cells and its secretome in cisplatin-induced nephrotoxicity: effects on oxidative stress and histological changes
  15. Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice
  16. Antioxidant activity in off and on-pump coronary artery bypass grafting and valve replacement surgery
  17. A drug utilisation pattern in non-dialysis patients of diabetic nephropathy in a government-run tertiary care hospital in South-Asia
  18. Inguinal lymphadenectomy in penile cancer patients: a comparison between open and video endoscopic approach in a multicenter setting
  19. A randomized controlled trial to evaluate the efficacy of electrical vestibular nerve stimulation (VeNS), compared to a sham control for the management of sleep in young adults
  20. Short Communication
  21. The role of Bruton’s kinase inhibitors (BTKi) in accelerated Chronic Lymphocytic Leukemia (a-CLL): a case of successful response to acalabrutinib
  22. Letter to the Editor
  23. A hypothesis that Notopterol may be effective in COVID-19 via JAK/STAT and other signaling pathways
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