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The role of synbiotics in improving inflammatory status in nasopharyngeal carcinoma patients

  • Minidian Fasitasari EMAIL logo , Hertanto Wahyu Subagio and Suprihati Suprihati
Published/Copyright: June 6, 2022
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 34 Issue 3

Abstract

Nasopharyngeal carcinoma (NPC) is a malignant tumor that grows from the epithelial cells of nasopharynx. NPC has the ability to modify its metabolism and leads the patient to suffer from malnutrition and cachexia, therefore aggravates the occurrence of impaired inflammatory response. Currently, available treatments for NPC are chemotherapy, radiotherapy, or chemoradiotherapy. Despite of its efficacy, these regimens have been known to elicit various inflammation-related side effects including infection, diarrhea, and mucositis. It has long been established that increased activity of inflammatory response is associated to low survival rate in both early and advanced stage of cancer. Furthermore, uncontrolled and dysregulated inflammatory response are significantly correlated with malignant progression of cancer. Considering how pivotal inflammation to malignancy progression, there is a need for effective strategies to modulate inflammatory response. Various strategies have been proposed to improve immune response in NPC patients including dietary supplementation of synbiotics. Synbiotics refers to the manipulation of both probiotics and prebiotics to provide a synergistic benefit to the host by promoting the growth of beneficial bacteria while inhibiting the growth of pathogenic bacteria. There is a growing number of evidences related to the potential of synbiotics in modulating the pro-inflammatory response and improve immune systems in a variety of conditions, including cancer. In this study, we will discuss the immunomodulatory effects of synbiotics in the nasopharyngeal carcinoma occurrences.

Keywords: nasopharyngeal carcinoma; nutrition; oncology; prebiotics; probiotics; synbiotics
Corresponding author: Minidian Fasitasari, MD, MSc, Department of Nutrition, Medical Faculty of Universitas Islam Sultan Agung, Semarang, Indonesia, Phone: +62 24 6582455, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

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Received: 2021-10-18
Accepted: 2022-04-29
Published Online: 2022-06-06

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2021-0320
Keywords for this article
nasopharyngeal carcinoma; nutrition; oncology; prebiotics; probiotics; synbiotics

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Investigating periprostatic adipose tissue as a driving force of prostate cancer progression: a new source of information for the advancement of targeted therapy in metastatic prostate cancer
  4. Reviews
  5. Pathophysiological effects of cadmium(II) on human health-a critical review
  6. The role of synbiotics in improving inflammatory status in nasopharyngeal carcinoma patients
  7. Anti-ageing effects of FDA-approved medicines: a focused review
  8. Diagnosis and management of uterine fibroids: current trends and future strategies
  9. Importance of moderate-to-vigorous physical activity during the COVID-19 pandemic: a systematic review and meta-analysis
  10. Original Articles
  11. Healthcare workers’ knowledge of evidence-based guidelines for prevention of ventilator-associated pneumonia in Hodeida, Yemen
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  15. Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice
  16. Antioxidant activity in off and on-pump coronary artery bypass grafting and valve replacement surgery
  17. A drug utilisation pattern in non-dialysis patients of diabetic nephropathy in a government-run tertiary care hospital in South-Asia
  18. Inguinal lymphadenectomy in penile cancer patients: a comparison between open and video endoscopic approach in a multicenter setting
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  23. A hypothesis that Notopterol may be effective in COVID-19 via JAK/STAT and other signaling pathways
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