Yoyo Bitters, a polyherbal formulation influenced some biochemical parameters in Wistar rats
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Oluyomi Stephen Adeyemi
,
Moyinoluwa Fambegbe
Abstract
Background: Yoyo Bitters is an indigenous polyherbal preparation widely consumed in Nigeria. In spite of its wide consumption there is little scientific data on the safety/toxicity profile of Yoyo Bitters. This study determined the biochemical effect of daily administration of Yoyo Bitters on rat serum, kidney and liver.
Methods: A total of 20 Wistar rats, of average weight between 175 and 200 g, were randomly distributed into four groups of five rats each. Group A served as controls and received distilled water. Groups B, C and D were given Yoyo Bitters at various dosages. Treatments were orally administered for 28 days.
Results: Yoyo Bitters caused lipid peroxidation as reflected in serum and liver malondialdehyde (MDA) levels which were significantly (p<0.05) elevated in a dose-dependent manner. In groups treated with 1206.5 mg and 804.3 mg/kg dosages of Yoyo Bitters, serum superoxide dismutase (SOD) levels were also significantly (p<0.05) increased. By contrast, Yoyo Bitters caused a dose-dependent reduction in reduced glutathione (GSH) levels. It is not clear if free radicals or lipid peroxidation caused changes in SOD and GSH levels. However, Yoyo Bitters may have enhanced free radical generation and ensuing lipid peroxidation leading to increased SOD and subsequent dose-dependent depletion of GSH levels.
Conclusions: In light of this, caution and adherence to dosage prescription is strongly advised. This study is a contribution to scientific knowledge on the safety/toxicity profile of Yoyo Bitters among the growing list of Nigerian herbal remedies.
©2012 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Masthead
- Masthead
- Original Articles
- Yoyo Bitters, a polyherbal formulation influenced some biochemical parameters in Wistar rats
- Combinatorial cytotoxic effects of Curcuma longa and Zingiber officinale on the PC-3M prostate cancer cell line
- The influence of oxonate-induced hyperuricemia and allopurinol on behavioral reactions of random-bred mice
- Acetylcholinesterase (AChE) inhibitory activity, antioxidant properties and phenolic composition of two Aframomum species
- An in vitro study of the ameliorative role of α-tocopherol on methotrexate-induced oxidative stress in rat heart mitochondria
- Study on blood glucose concentration in patients with diabetes undergoing dental extraction under local anesthesia with and without adrenaline
- Drug use evaluation of diabetes mellitus in hospitalized patients of a tertiary care referral hospital
- Biochemical and morphological changes in Trypanosoma brucei brucei- infected rats treated with homidium chloride and diminazene aceturate
