Biochemical and morphological changes in Trypanosoma brucei brucei- infected rats treated with homidium chloride and diminazene aceturate
-
Oluyomi Stephen Adeyemi
and
Faoziyat Adenike Sulaiman
Abstract
Background: Chemotherapy which is one of the major methods for controlling trypanosomal infections is beset with several challenges including unwanted toxicity and limited efficacy. These factors and others underscore research efforts aimed at finding safer and more effective therapeutic agents for trypanosomiasis. Homidium chloride and diminazene aceturate are registered drugs for the treatment of animal trypanosomiasis.
Methods: Study investigated and compared, in an experimental Trypanosoma infection, the effects of two trypanocides on the pathology of tissues and some biochemical indices in rats.
Results: Data revealed that the levels of alkaline phosphatase, alanine transaminase and aspartate transaminase in infected positive animals were significantly (p<0.05) elevated relative to uninfected negative controls but showed no significant difference when compared with the trypanocide-treatment groups. The histopathological presentations in the infected and treatment groups are a demonstration of the inimical cellular alterations associated with Trypanosoma brucei brucei infection.
Conclusions: The inimical alterations to biochemical and morphological parameters observed in the infected as well as the treatment groups is an implication suggesting shortcomings of the investigated trypanocides to alleviate pathology associated with Trypanosoma brucei brucei infection. We present evidence that further supports the urgent need for the development of safer and more effective trypanocides.
©2012 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Masthead
- Masthead
- Original Articles
- Yoyo Bitters, a polyherbal formulation influenced some biochemical parameters in Wistar rats
- Combinatorial cytotoxic effects of Curcuma longa and Zingiber officinale on the PC-3M prostate cancer cell line
- The influence of oxonate-induced hyperuricemia and allopurinol on behavioral reactions of random-bred mice
- Acetylcholinesterase (AChE) inhibitory activity, antioxidant properties and phenolic composition of two Aframomum species
- An in vitro study of the ameliorative role of α-tocopherol on methotrexate-induced oxidative stress in rat heart mitochondria
- Study on blood glucose concentration in patients with diabetes undergoing dental extraction under local anesthesia with and without adrenaline
- Drug use evaluation of diabetes mellitus in hospitalized patients of a tertiary care referral hospital
- Biochemical and morphological changes in Trypanosoma brucei brucei- infected rats treated with homidium chloride and diminazene aceturate
