Startseite Numerical and Experimental Study on a Microfluidic Concentration Gradient Generator for Arbitrary Approximate Linear and Quadratic Concentration Curve Output
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Numerical and Experimental Study on a Microfluidic Concentration Gradient Generator for Arbitrary Approximate Linear and Quadratic Concentration Curve Output

  • Xueye Chen EMAIL logo , Zengliang Hu , Lei Zhang , Zhen Yao , Xiaodong Chen , Yue Zheng , Yanlin Liu , Qing Wang , Yang Liu , Xuemiao Cui und Hongxu Song
Veröffentlicht/Copyright: 11. Mai 2017
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Abstract

This work introduces a simple and versatile method for researching the concentration gradient generator (CGG) which can present the arbitrary approximate linear and quadratic concentration gradient curves output. The concentration gradients of arbitrary approximate linear curves with two inlets and arbitrary quadratic curves in the CGG with three inlets are obtained with the corresponding flow velocities. The CGG was simulated basing on the finite element method (FEM). The fluid-dynamic and mass-transport about the CGG was studied. Moreover, the feasibility of simulation was clearly verified by an experiment which two microfluidic chips of CGG on the PMMA substrate were processed using CNC engraving and milling machine. The paper successfully demonstrates the controllability of concentration gradient profiles in CGG with two inlets and three inlets. The study on the CGG can help the trends study of cell and molecule in different samples in the biochemical engineering.

Funding statement: This work was supported by National Natural Science Foundation of China (51405214), Liaoning Province Doctor Startup Fund (20141131), Fund of Liaoning Province Education Administration (L2014241), and the Fund in Liaoning University of Technology (X201301). Thanks Prof. Liu for COMSOL support.

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Published Online: 2017-5-11

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