Home Serum ischemia-modified albumin levels in adolescent smokers
Article
Licensed
Unlicensed Requires Authentication

Serum ischemia-modified albumin levels in adolescent smokers

  • Fatih Battal , Mustafa Tekin , Hakan Aylanç , Şule Yıldırım EMAIL logo , Hakan Türkön , Fatih Köksal Binnetoğlu , Nazan Kaymaz and Naci Topaloğlu
Published/Copyright: April 9, 2016

Abstract

Background:

It is known that the biochemical marker linked to tissue ischemia, ischemia-modified albumin (IMA), is related to oxidative stress. Cigarette smoking is a situation with increased oxidative stress causing cell damage and it is thought that many of the negative effects linked to smoking may occur after the biological material in the body is exposed to oxidative damage. This study aimed to identify variability in serum IMA levels in adolescents who smoke.

Methods:

This case-control study comprised 60 adolescents without any chronic disease. The smoking group was 30 adolescents between the ages of 14 and 17 years who smoked, while the control group was 30 healthy adolescents who did not smoke. Blood samples were collected from all subjects and serum IMA levels and serum nicotine metabolites were determined.

Results:

The serum IMA levels in the adolescents who smoked were 0.452±0.094 absorbance unit (ABSU), while the control group had ASBU levels of 0.427±0.054. There was no significant difference between the groups in terms of serum IMA levels (p=0.210). There was a significant difference between the control and smoking groups in terms of serum nicotine metabolite levels (p<0.001).

Conclusions:

Among adolescents who smoke, serum IMA levels may not be a good marker for oxidative stress.

  1. Conflict of interest statement: All authors listed have contributed sufficiently to the project to be included as authors. To the best of our knowledge, no conflict of interest, financial or other, exists.

References

1. O’Loughlin J, DiFranza J, Tyndale RF, Meshefedjian G, McMillan-Davey E, et al. Nicotine-dependence symptoms are associated with smoking frequency in adolescents. Am J Prev Med 2003;25:219–25.10.1016/S0749-3797(03)00198-3Search in Google Scholar PubMed

2. Arday DR, Ary DV, Booth M, Dee B, Chaloupka IV FJ, et al. Preventing tobacco use among young people: a report of the surgeon general. US Department of Health and Human Services, Atlanta, GA, 1994.Search in Google Scholar

3. Church DF, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985;64:111–26.10.1289/ehp.8564111Search in Google Scholar PubMed PubMed Central

4. Pryor WA, Stone K. Oxidants in cigarette smoke radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann N Y Acad Sci 1993;686:27–8.10.1111/j.1749-6632.1993.tb39148.xSearch in Google Scholar PubMed

5. Schetter AJ, Heegaard NHH, Harris CC. Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis 2010;31:37–49.10.1093/carcin/bgp272Search in Google Scholar PubMed PubMed Central

6. Harman D. Free radical theory of aging: an update. Ann N Y Acad 2006;1067:10–21.10.1196/annals.1354.003Search in Google Scholar PubMed

7. Osoata GO, Yamamura S, Ito M, Vuppusetty C, Adcock IM, et al. Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. Biochem Biophys Res Commun 2009:384:366–71.10.1016/j.bbrc.2009.04.128Search in Google Scholar PubMed

8. Kirkham PA, Caramori G, Casolari P, Papi AA, Edwards M, et al. Oxidative stress—induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011;184:796–802.10.1164/rccm.201010-1605OCSearch in Google Scholar PubMed PubMed Central

9. Mahapatra SK, Das S, Dey SK, Somenath R. Smoking induced oxidative stress in serum and neutrophil of the university students. Al Ameen J Med Sci 2008;1:20–31.Search in Google Scholar

10. Duarte MM, Rocha JB, Moresco RN, Duarte T, Da Cruz IB, et al. Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia. Clin Biochem 2009;42:666–71.10.1016/j.clinbiochem.2009.01.010Search in Google Scholar PubMed

11. Kaefer M, Piva SJ, De Carvalho JA, Da Silva DB, Becker AM, et al. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. Clin Biochem 2010;43:450–4.10.1016/j.clinbiochem.2009.11.018Search in Google Scholar PubMed

12. Valle Gottlieb MG, DaCruz IB, Duarte MM, Moresco RN, Wiehe M, et al. Associations among metabolic syndrome, ischemia, inflammatory, oxidatives and lipids biomarkers. J Clin Endocrinol Metab 2010;95:586–91.10.1210/jc.2009-1592Search in Google Scholar PubMed PubMed Central

13. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes-review and clinical implications. Clin Chem Lab Med 2011;49:177–84.10.1515/CCLM.2011.037Search in Google Scholar PubMed

14. Cakir M, Karahan SC, Mentese A, Sag E, Cobanoglu U, et al. Ischemia-modified albumin levels in children with chronic liver disease. Gut Liver 2012;6:92–7.10.5009/gnl.2012.6.1.92Search in Google Scholar PubMed PubMed Central

15. Gunduz A, Turkmen S, Turedi S, Mentese A, Yulug E, et al. Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia. Acad Emerg Med 2009;16:539–43.10.1111/j.1553-2712.2009.00414.xSearch in Google Scholar PubMed

16. Hacker M, Hoyer HX, La Fougère C, Akcakoyunlu E, Schuhmann C, et al. Effects of peripheral vascular intervention on ischemia-modified albumin. Coron Artery Dis 2007;18:375–9.10.1097/MCA.0b013e3281ac2094Search in Google Scholar PubMed

17. SeneŞ M, Kazan N, Coşkun O, Zengi O, Inan L, et al. Oxidative and nitrosative stress in acute ischaemic stroke. Ann Clin Biochem 2007;44:43–7.10.1258/000456307779596057Search in Google Scholar PubMed

18. Ellidag HY, Bulbuller N, Eren E, Abusoglu S, Akgol E, et al. Ischemia-modified albumin: could it be a new oxidative stress biomarker for colorectal carcinoma? Gut Liver 2013;7:675–80.10.5009/gnl.2013.7.6.675Search in Google Scholar PubMed PubMed Central

19. Ellidag HY, Eren E, Yilmaz N, Bayindir A. Ischemia modified albumin levels and increased oxidative stress in patients with multiple myeloma. J Med Biochem 2014;33:175–80.10.2478/jomb-2013-0027Search in Google Scholar

20. Borderie D, Allanore Y, Meune C, Devaux JY, Ekindjian OG, et al. High ischemia-modified albumin concentration reflects oxidative stress but not myocardial involvement in systemic sclerosis. Clin Chem 2004;50:2190–3.10.1373/clinchem.2004.034371Search in Google Scholar PubMed

21. Albarello K, Dos Santos GA, Bochi GV, Sangoi MB, Almeida TC, et al. Ischemia modified albumin and carbonyl protein as potential biomarkers of protein oxidation in hemodialysis. Clin Biochem 2012;45:450–4.10.1016/j.clinbiochem.2012.01.031Search in Google Scholar PubMed

22. Vincent HK, Taylor AG. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes (Lond) 2006;30:400–18.10.1038/sj.ijo.0803177Search in Google Scholar PubMed

23. Turedi S, Patan T, Gunduz A, Mentese A, Tekinbas C, et al. Ischemia-modified albumin in the diagnosis of pulmonary embolism: an experimental study. Am J Emerg Med 2009;27:635–40.10.1016/j.ajem.2008.05.002Search in Google Scholar

24. Lippi G, Montagnana M, Salvagno GL, Guidi GC. Potential value for new diagnostic markers in the early recognition of acute coronary syndromes. CJEM 2006;8:27–31.10.1017/S148180350001335XSearch in Google Scholar PubMed

25. Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt albumin binding and its potential as a marker for myocardial ischemia—A preliminary report. J Emerg Med 2000;19:311–5.10.1016/S0736-4679(00)00255-9Search in Google Scholar PubMed

26. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44–84.10.1016/j.biocel.2006.07.001Search in Google Scholar PubMed

27. Dundar ZD, Cander B, Gul M, Karabulut KU, Girisgin S. Serum ischemia-modified albumin levels in an experimental acute mesenteric ischemia model. Acad Emerg Med 2010;17:1233–8.10.1111/j.1553-2712.2010.00916.xSearch in Google Scholar PubMed

28. Erem C, Suleyman AK, Civan N, Mentese A, Nuhoglu I, et al. Ischemia-modified albümin and malondialdehyde levels in patients with overt and subclinical hyperthyroidism: effects of treatment on oxidative stress. Endocr J 2015;62:493–501.10.1507/endocrj.EJ14-0542Search in Google Scholar PubMed

29. Toker A, Kucuksen S, Kucuk A, Çicekler H. Serum ischemia-modified albumin and malondialdehyde levels and superoxide dismutase activity in patients with fibromyalgia. Clin Lab 2014;60:1609–15.10.7754/Clin.Lab.2014.131017Search in Google Scholar PubMed

30. Şahinli AS, Marakoğlu K, Kiyici A. Evaluation of the levels of oxidative stress factors and ischemia modified albumin in the cord blood of smoker and non-smoker pregnant women. J Matern Fetal Neonatal Medschetterduarte 2012;25:1064–8.10.3109/14767058.2011.622001Search in Google Scholar PubMed

Received: 2015-12-28
Accepted: 2016-2-28
Published Online: 2016-4-9

©2018 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Editorial
  2. Pre-aesculapian messages from ancient archives of Mesopotamia: the Epic of Gilgamesh and the library of Ashurbanipal
  3. Review
  4. A systematic review on critical thinking in medical education
  5. Original Articles
  6. Persistence of metabolic syndrome and its impact on glucose metabolism in overweight and obese children and adolescents
  7. Cross-sectional analysis of food choice frequency, sleep confounding beverages, and psychological distress predictors of sleep quality
  8. Adolescents’ knowledge and opinions about smoking: a qualitative study from the Jhaukhel-Duwakot Health Demographic Surveillance Site, Bhaktapur District, Nepal
  9. A qualitative study on how adolescent males in South India view reproductive health
  10. Perception of primary school teachers to school children’s mental health problems in Southwest Ethiopia
  11. Preparation for sexual and reproductive self-care in Iranian adolescent girls: a qualitative study
  12. Serum ischemia-modified albumin levels in adolescent smokers
  13. Perceptions and use of sources of health knowledge by young adolescents
  14. An exploratory study of fears among adolescent students from an urban cohort in India
  15. Alcohol misuse and gateway theory: a longitudinal study among adolescents in Switzerland
  16. Two-year prospective study of characteristics and outcome of adolescents referred to an adolescent urgent psychiatric clinic
  17. Screening for celiac disease in patients with eating disorders
  18. Clustering of behavioural risk factors for non-communicable diseases (NCDs) among rural-based adolescents in south-west Nigeria
  19. Knowledge, attitude, self-efficacy and estimation of frequency of condom use among Iranian students based on a crosswise model
  20. Depressive symptoms, hostility, and hopelessness in inner-city adolescent health clinic patients: factor structure and demographic correlates
  21. Short Communications
  22. Japanese university students’ views on lesbian, gay, bisexual, and transgender individuals based on previous encounters
  23. YouTube™ videos related to human papillomavirus: the need for professional communication
  24. Utility of salivary enzyme immunoassays for measuring estradiol and testosterone in adolescents: a pilot study
  25. Salivary testosterone as a potential indicator for risky behaviour associated with smoking-related peer pressure in adolescents
Downloaded on 9.9.2025 from https://www.degruyterbrill.com/document/doi/10.1515/ijamh-2015-0128/html
Scroll to top button