Startseite Aortic dilatation and dissection in Turner syndrome: What we know, what we are unclear about and what we should do in clinical practice?
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Aortic dilatation and dissection in Turner syndrome: What we know, what we are unclear about and what we should do in clinical practice?

  • Sze Choong Wong EMAIL logo , Michael Cheung und Margaret Zacharin
Veröffentlicht/Copyright: 31. Mai 2014

Abstract

Aortic dilatation and aortic dissection are increasingly recognised in patients with Turner syndrome (TS). Risk factors for aortic dissection include aortic dilatation, bicuspid aortic valves, coarctation of aorta and pregnancy. The risk of death due to aortic dissection in pregnancy in TS is 2%, which is approximately 100 times higher than the general population, as maternal mortality is extremely low. Ongoing cardiovascular monitoring is recommended, although there remain several unanswered questions in relation to cardiovascular imaging especially the choice of modality for detection of vascular, valvular abnormalities and measurements of aortic dimensions. Due to the relative short stature of patients with TS, aortic dimensions need to be defined by aortic measurements adjusted for body surface area, known as aortic sized index (ASI). The relationship of ASI and other risk factors with aortic dissection is only beginning to be clarified. Clinical management and monitoring of such patients should be delivered by a group of clinicians familiar with the issues unique to TS patients in a multidisciplinary fashion. All clinicians including the non-specialists need to have a low threshold of suspecting aortic dissection in these adolescents and young adults. This up to date review, including a summary of all 122 published cases of TS patients with aortic dissection, aims to provide a summary of recent publications on characteristics of aortic dissection and aortic dilatation in TS to highlight gaps in knowledge and propose possible clinical monitoring pathway of cardiovascular health in children and adults with TS. Cardiovascular assessment and risk counselling is especially crucial during the period of transition of adolescents with TS, although life long monitoring by expert cognizant to the issues specific in TS is essential.


Corresponding author: Sze Choong Wong, Centre for Hormone Research, Murdoch Childrens Research Institute, Flemington Road, Parkville, Melbourne, VIC 3052, Australia, Phone: +613 93455951, E-mail:

Acknowledgements

The Murdoch Childrens Research Institute is supported by the Victorian Government’s Operational Infrastructure Support Program. The Heart Research Group is supported by RCH 1000, The Royal Children’s Hospital Foundation.

Conflict of interest statement

All the authors have no conflicts of interest to declare in relation to this clinical review.

References

1. Stochholm K, Juul S, Juel K, Naeraa RW, Gravholt CH. Prevalence, incidence, diagnostic delay, and mortality in Turner syndrome. J Clin Endocrinol Metab 2006;91:3897–902.10.1210/jc.2006-0558Suche in Google Scholar

2. Bondy CA. Aortic dissection in Turner syndrome. Curr Opin Card 2008;23:519–26.10.1097/HCO.0b013e3283129b89Suche in Google Scholar

3. Bondy CA. Heart disease in Turner syndrome. Minerva Endocrinologica 2007;32:245–61.Suche in Google Scholar

4. Bondy CA. Congenital cardiovascular disease in Turner syndrome. Congenit 2008;3:2–15.10.1111/j.1747-0803.2007.00163.xSuche in Google Scholar

5. Mortensen KH, Andersen NH, Gravholt CH. Cardiovascular phenotype in Turner syndrome—integrating cardiology, genetics, and endocrinology. Endocr Rev 2012;33:677–714.10.1210/er.2011-1059Suche in Google Scholar

6. Gotzsche CO, Krag-Olsen B, Nielsen J, Sorensen KE, Kristensen BO. Prevalence of cardiovascular malformations and association with karyotypes in Turner’s syndrome. Arch Dis Child 1994;71:433–6.10.1136/adc.71.5.433Suche in Google Scholar

7. Ho VB, Bakalov VK, Cooley M, Van PL, Hood MN, et al. Major vascular anomalies in Turner syndrome: prevalence and magnetic resonance angiographic features. Circulation 2004;110:1694–700.10.1161/01.CIR.0000142290.35842.B0Suche in Google Scholar

8. Mazzanti L, Cacciari E. Congenital heart disease in patients with Turner’s syndrome. Italian Study Group for Turner Syndrome (ISGTS). J Pediatr 1998;133:688–92.10.1016/S0022-3476(98)70119-2Suche in Google Scholar

9. Prandstraller D, Mazzanti L, Picchio FM, Magnani C, Bergamaschi R, et al. Turner’s syndrome: cardiologic profile according to the different chromosomal patterns and long-term clinical follow-Up of 136 nonpreselected patients. Pediatr Cardiol 1999;20:108–12.10.1007/s002469900416Suche in Google Scholar PubMed

10. Hjerrild BE, Mortensen KH, Sorensen KE, Pedersen EM, Andersen NH, et al. Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study. J Cardiovasc Magn Reson 2010;12:12.10.1186/1532-429X-12-12Suche in Google Scholar PubMed PubMed Central

11. Sachdev V, Matura LA, Sidenko S, Ho VB, Arai AE, et al. Aortic valve disease in Turner syndrome. J Am Coll Cardiol 2008;51:1904–9.10.1016/j.jacc.2008.02.035Suche in Google Scholar PubMed

12. Volkl TMK, Degenhardt K, Koch A, Simm D, Dorr HG, et al. Cardiovascular anomalies in children and young adults with Ullrich-Turner syndrome the Erlangen experience. Clin Cardiol 2005;28:88–92.10.1002/clc.4960280209Suche in Google Scholar

13. Olivieri LJ, Baba RY, Arai AE, Bandettini WP, Rosing DR, et al. Spectrum of aortic valve abnormalities associated with aortic dilation across age groups in Turner syndrome. Circ Cardiovasc Imaging 2013;6:1018–23.10.1161/CIRCIMAGING.113.000526Suche in Google Scholar

14. Kim HK, Gottliebson W, Hor K, Backeljauw P, Gutmark-Little I, et al. Cardiovascular anomalies in Turner syndrome: spectrum, prevalence, and cardiac MRI findings in a pediatric and young adult population. AJR Am J Roentgenol 2011;196:454–60.10.2214/AJR.10.4973Suche in Google Scholar

15. Price WH, Willey RF. Partial anomalous pulmonary venous drainage in two patients with Turner’s syndrome. J Med Genet 1980;17:133–4.10.1136/jmg.17.2.133Suche in Google Scholar

16. Fang J, Dagenais SL, Erickson RP, Arlt MF, Glynn MW, et al. Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome. Am J Hum Genet 2000;67:1382–8.10.1086/316915Suche in Google Scholar

17. Bondy C, Bakalov VK, Cheng C, Olivieri L, Rosing DR, et al. Bicuspid aortic valve and aortic coarctation are linked to deletion of the X chromosome short arm in Turner syndrome. J Med Genet 2013;50:662–5.10.1136/jmedgenet-2013-101720Suche in Google Scholar

18. Kim J, Park J, Choi S, Chi S-G, Mowbray AL, et al. X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival. Circ Res 2008;102:896–904.10.1161/CIRCRESAHA.107.163667Suche in Google Scholar

19. Gravholt CH, Landin-Wilhelmsen K, Stochholm K, Hjerrild BE, Ledet T, et al. Clinical and epidemiological description of aortic dissection in Turner’s syndrome. Cardiol Young 2006;16:430–6.10.1017/S1047951106000928Suche in Google Scholar

20. Gopal AS, Arora NS, Vardanian S, Messineo FC. Utility of transesophageal echocardiography for the characterization of cardiovascular anomalies associated with Turner’s syndrome. J Am Soc Echocardiogr 2001;14:60–2.10.1067/mje.2001.109197Suche in Google Scholar

21. Rubin K. Aortic dissection and rupture in Turner syndrome. J Pediatr 1993;122:670.10.1016/S0022-3476(05)83571-1Suche in Google Scholar

22. Price WH, Wilson J. Dissection of the aorta in Turner’s syndrome. J Med Genet 1983;20:61–3.10.1136/jmg.20.1.61Suche in Google Scholar

23. Sybert VP. Cardiovascular malformations and complications in Turner syndrome. Pediatrics 1998;101:E11.10.1542/peds.101.1.e11Suche in Google Scholar

24. Price WH, Clayton JF, Collyer S, De Mey R, Wilson J. Mortality ratios, life expectancy, and causes of death in patients with Turner’s syndrome. J Epidemiol Community Health 1986;40: 97–102.10.1136/jech.40.2.97Suche in Google Scholar

25. Hirose H, Amano A, Takahashi A, Nagano N, Kohmoto T. Ruptured aortic dissecting aneurysm in Turner’s syndrome: a case report and review of literature. Ann Thorac Cardiovasc Surg 2000;6:275–80.Suche in Google Scholar

26. Chlumsky J, Kolbel F, Buresova M, Svab P, Krutilkova V, et al. [A dissecting aortic aneurysm in a female patient with Turner syndrome]. Vnitr Lek 2000;46:34–6.Suche in Google Scholar

27. Meunier JP, Jazayeri S, David M. Acute type A aortic dissection in an adult patient with Turner’s syndrome. Heart 2001;86:546.10.1136/heart.86.5.546Suche in Google Scholar

28. Clement CI, Brereton J, Clifton-Bligh P. Aortic dissection in Turner syndrome. Med J Australia 2004;180:584.10.5694/j.1326-5377.2004.tb06097.xSuche in Google Scholar

29. Buheitel G, Singer H, Hofbeck M. [Aortic aneurysms in Ullrich-Turner syndrome]. Klin Padiatr 1996;208:42–5.10.1055/s-2008-1043992Suche in Google Scholar

30. Kusaba E, Imada T, Iwakuma A, Nonaka K. [Aortic aneurysm complicated with coarctation of the aorta and Turner syndrome]. Kyobu geka 1995;48:1115–7.Suche in Google Scholar

31. Allemann J, Muller G, Legat M. [Rare variant of a Turner-Ullrich syndrome]. Schweiz Med Wochenschr 1982;112:1249–55.Suche in Google Scholar

32. Lin AE, Lippe B, Rosenfeld RG. Further delineation of aortic dilation, dissection, and rupture in patients with Turner syndrome. Pediatrics 1998;102:e12.10.1542/peds.102.1.e12Suche in Google Scholar

33. Kostich ND, Opitz JM. Ullrich-Turner syndrome associated with cystic medial necrosis of the aorta and great vessels: case report and review of the literature. Am J Med 1965;38:943–50.10.1016/0002-9343(65)90014-8Suche in Google Scholar

34. Lippe BM, Kogut MD. Aortic rupture in gonadal dysgenesis. J Pediatr 1972;80:895–6.10.1016/S0022-3476(72)80162-8Suche in Google Scholar

35. Weytjens C, Bove T, Van Der Niepen P. Aortic dissection and Turner’s syndrome. J Cardiovasc Surg 2000;41:295–7.Suche in Google Scholar

36. Fejzic Z, van Oort A. Fatal dissection of the descending aorta after implantation of a stent in a 19-year-old female with Turner’s syndrome. Cardiol Young 2005;15:529–31.10.1017/S1047951105001447Suche in Google Scholar PubMed

37. Bordeleau L, Cwinn A, Turek M, Barron-Klauninger K, Victor G. Aortic dissection and Turner’s syndrome: case report and review of the literature. J Emerg Med 1998;16:593–6.10.1016/S0736-4679(98)00041-9Suche in Google Scholar

38. Landin-Wilhelmsen K, Bryman I, Hanson C, Hanson L. Spontaneous pregnancies in a Turner syndrome woman with Y-chromosome mosaicism. J Assist Reprod Genet 2004;21:229–30.10.1023/B:JARG.0000040239.40913.c3Suche in Google Scholar

39. Badmanaban B, Mole D, Sarsam MAI. Descending aortic dissection post coarctation repair in a patient with Turner’s syndrome. J Cardiac Surg 2003;18:153–4.10.1046/j.1540-8191.2003.02001.xSuche in Google Scholar

40. Bartlema KA, Hogervorst M, Akkersdijk GJ, Seelen J, Hoogland P, et al. Isolated abdominal aortic dissection in a patient with Turner’s syndrome. Surgery 1995;117:116–7.10.1016/S0039-6060(05)80241-7Suche in Google Scholar

41. Nagel TC, Tesch LG. ART and high risk patients. Fertil Steril 1997;68:748–9.Suche in Google Scholar

42. Hata J. Ultrastructural and histochemical studies on aortic dissection aneurysm. Myok Kangaku 1986;26:493–8.Suche in Google Scholar

43. Asch AJ. Turner’s syndrome occurring with Horner’s syndrome. Seen with coarctation of the aorta and aortic aneurysm. Am J Dis Child 1979;133:827–30.10.1001/archpedi.1979.02130080067013Suche in Google Scholar

44. Guerin FGD de Saint-Maur P, Akoun J, Josso N. Dissection aortique et syndrome de Turner. Couer 1974;5:771–5.Suche in Google Scholar

45. Imamura M, Aoki H, Eya K, Murakami T, Yasuda K. Balloon angioplasty before Wheat’s operation in a patient with Turner’s syndrome. Cardiovasc Surg 1995;3:70–2.10.1016/0967-2109(95)92908-ZSuche in Google Scholar

46. Ohuchi H, Takasugi H, Ohashi H, Okada Y, Yamada O, et al. Stratification of pediatric heart failure on the basis of neurohormonal and cardiac autonomic nervous activities in patients with congenital heart disease. Circulation 2003;108:2368–76.10.1161/01.CIR.0000101681.27911.FASuche in Google Scholar

47. Goldberg SM, Pizzarello RA, Goldman MA, Padmanabhan VT. Aortic dilatation resulting in chronic aortic regurgitation and complicated by aortic dissection in a patient with Turner’s syndrome. Clin Cardiol 1984;7:233–5.10.1002/clc.4960070408Suche in Google Scholar

48. Beauchesne LM, Connolly HM, Ammash NM, Warnes CA. Coarctation of the aorta: outcome of pregnancy. J Am Coll Cardiol 2001;38:1728–33.10.1016/S0735-1097(01)01617-5Suche in Google Scholar

49. Shiroma K, Ebine K, Tamura S, Yokomuro M, Suzuki H, et al. A case of Turner’s syndrome associated with partial anomalous pulmonary venous return complicated by dissecting aortic aneurysm and aortic regurgitation. J Cardiovasc Surg 1997; 38:257–9.Suche in Google Scholar

50. Apostolopoulos T, Kyriakidis M, Toutouzas P. Endarteritis of the aortic arch in Turner’s syndrome with cystic degeneration of the aorta. Int J Cardiol 1992;35:417–9.10.1016/0167-5273(92)90244-WSuche in Google Scholar

51. Slater DN, Grundman MJ, Mitchell L. Turner’s syndrome associated with bicuspid aortic stenosis and dissecting aortic aneurysm. Postgrad Med J 1982;58:436–8.10.1136/pgmj.58.681.436Suche in Google Scholar

52. Ravelo HR, Stephenson LW, Friedman S, Chatten J, Rashkind WJ, et al. Coarctation resection in children with Turner’s syndrome: a note of caution. J Thorac Cardiovasc Surg 1980;80:427–30.10.1016/S0022-5223(19)37770-0Suche in Google Scholar

53. Oohara K, Yamazaki T, Sakaguchi K, Nakayama M, Kobayashi A. Acute aortic dissection, aortic insufficiency, and a single coronary artery in a patient with Turner’s syndrome. J Cardiovasc Surg 1995;36:273–5.Suche in Google Scholar

54. Kido G, Miyagi A, Shibuya T, Miyagami M, Tsubokawa T, et al. [Turner’s syndrome with pituitary hyperplasia: a case report]. No Shinkei Geka 1994;22:333–8.Suche in Google Scholar

55. Akimoto N, Shimizu T, Ishikawa M, Ishimaru S, Furukawa K. The surgical treatment of aortic dissection in a patient with Turner’s syndrome: report of a case. Surgery Today 1994;24:929–32.10.1007/BF01651013Suche in Google Scholar

56. Salgado CR. [Turner’s syndrome. Report of a case associated with dissecting aneurysm of the aorta. Review of the literature]. Rev Fac Cienc Med Cordoba 1961;19:193–204.Suche in Google Scholar

57. Ota Y, Tsunemoto M, Shimada M, Ishizawa A, Koike K, et al. [Aortic dissection associated with Turner’s syndrome]. Kyobu Geka 1992;45:411–4.Suche in Google Scholar

58. Youker JE, Roe BB. Aneurysm of the aortic sinuses and ascending aorta in Turner’s syndrome. Am J Cardiol 1969;23:89–93.10.1016/0002-9149(69)90246-XSuche in Google Scholar

59. Cecchi F, Samoun M, Santoro G, Calamai G. [Chronic dissecting aortic aneurysm and Turner’s syndrome. Apropos of a case]. Arch Mal Coeur Vaiss 1992;85:1043–6.Suche in Google Scholar

60. Subramaniam PN. Turner’s syndrome and cardiovascular anomalies: a case report and review of the literature. Am J Med Sci 1989;297:260–2.10.1097/00000441-198904000-00014Suche in Google Scholar

61. Anabtawi IN, Ellison RG, Yeh TJ, Hall DP. Dissecting aneurysm of aorta associated with Turner’s syndrome. J Thorac Cardiovasc Surg 1964;47:750–4.10.1016/S0022-5223(19)33503-2Suche in Google Scholar

62. Lie JT. Aortic dissection in Turner’s syndrome. Am Heart J 1982;103:1077–80.10.1016/0002-8703(82)90577-4Suche in Google Scholar

63. Pollak H, Veit F, Enenkel W. [Presumed “successful” fibrinolysis in unrecognized acute aortic dissection]. Dtsch Med Wochenschr 1992;117:368–71.10.1055/s-2008-1062321Suche in Google Scholar PubMed

64. Hochberg Z. Sudden death in Turner’s syndrome. Harefuh 1995;129:285–8.Suche in Google Scholar

65. Jeresaty RM, Basu SK, Franco J. Dissecting aneurysm of the aorta in Turner’s syndrome. J Am Med Assoc 1972;222:574–6.10.1001/jama.1972.03210050046010Suche in Google Scholar

66. Miller JM, Herrera EL, Puga UC, Torres GS. Sindrome de Turner y aneurisma disecante de la aorta. Arch Inst Cardiol Mex 1974;44:771–5.Suche in Google Scholar

67. Carlson M, Airhart N, Lopez L, Silberbach M. Moderate aortic enlargement and bicuspid aortic valve are associated with aortic dissection in Turner syndrome: report of the international turner syndrome aortic dissection registry. Circulation 2012;126:2220–6.10.1161/CIRCULATIONAHA.111.088633Suche in Google Scholar PubMed

68. Carlson M, Silberbach M. Dissection of the aorta in Turner syndrome: two cases and review of 85 cases in the literature. J Med Genet 2007;44:745–9.10.1136/jmg.2007.052019Suche in Google Scholar PubMed PubMed Central

69. Matura LA, Ho VB, Rosing DR, Bondy CA. Aortic dilatation and dissection in Turner syndrome. Circulation 2007;116:1663–70.10.1161/CIRCULATIONAHA.106.685487Suche in Google Scholar PubMed

70. Chevalier N, Letur H, Lelannou D, Ohl J, Cornet D, et al. Materno-fetal cardiovascular complications in Turner syndrome after oocyte donation: insufficient prepregnancy screening and pregnancy follow-up are associated with poor outcome. J Clin Endocrinol Metab 2011;96:E260–7.10.1210/jc.2010-0925Suche in Google Scholar PubMed

71. Pleskacova J, Rucklova K, Popelova J, Cerny S, Syrucek M, et al. Aortic dissection and rupture in a 16-year-old girl with Turner syndrome following previous progression of aortic dilation. Eur J Pediatr 2010;169:1283–6.10.1007/s00431-010-1197-4Suche in Google Scholar PubMed

72. Mimasaka S, Ohtsu Y, Tsunenari S, Matsukawa A, Hashiyada M, et al. Sudden death of a young woman due to aortic dissection caused by Turner’s syndrome. Pathol Int 2007;57:219–23.10.1111/j.1440-1827.2007.02084.xSuche in Google Scholar PubMed

73. Oza NM, Siegenthaler M, Horvath K, Rosing DR, Chen MY, et al. Serious aortic complications in a patient with Turner syndrome. Eur J Pediatr 2013;172:703–5.10.1007/s00431-012-1808-3Suche in Google Scholar PubMed PubMed Central

74. Kin H, Okabayashi H, Nakajima T, Takahashi K. Aortic dissecting aneurysm with a bicuspid aortic valve in Turner’s syndrome: report of a case. Surgery Today 2007;37:667–70.10.1007/s00595-006-3462-8Suche in Google Scholar PubMed

75. Maureira JP, Vanhuyse F, Lekehal M, Hubert T, Vigouroux C, et al. Failure of Marfan anatomic criteria to predict risk of aortic dissection in Turner syndrome: necessity of specific adjusted risk thresholds. Interact Cardiovasc Thorac Surg 2012;14: 610–4.10.1093/icvts/ivr172Suche in Google Scholar PubMed PubMed Central

76. Jagannath AD, Rastogi U, Spooner AE, Lin AE, Agnihotri AK. Aortic dissection and moyamoya disease in Turner syndrome. Am J Med Genet A 2010;152A:2085–9.10.1002/ajmg.a.33539Suche in Google Scholar PubMed

77. Di Eusanio M, Pilato E, Pantaleo A, Di Bartolomeo R. Type B aortic dissection complicating an isthmic coarctation in a Turner patient. J Cardiovasc Med (Hagerstown). 2012;13:225–8.10.2459/JCM.0b013e32833b9653Suche in Google Scholar PubMed

78. Boissonnas CC, Davy C, Bornes M, Arnaout L, Meune C, et al. Careful cardiovascular screening and follow-up of women with Turner syndrome before and during pregnancy is necessary to prevent maternal mortality. Fertil Steril 2009;91:929.e5–7.10.1016/j.fertnstert.2008.09.037Suche in Google Scholar

79. Ohl J. [Oocyte donation in Turner syndrome]. Gynecologie, Obstetrique & Fertilite 2008;36:886–90.10.1016/j.gyobfe.2008.06.019Suche in Google Scholar

80. Garvey P, Elovitz M, Landsberger EJ. Aortic dissection and myocardial infarction in a pregnant patient with Turner syndrome. Obstet Gynecol 1998;91(5 Pt 2):864.10.1016/S0029-7844(97)00546-2Suche in Google Scholar

81. Strader WJ, 3rd, Wachtel HL, Lundberg GD, Jr. Hypertension and aortic rupture in gonadal dysgenesis. J Pediatr 1971;79: 473–5.10.1016/S0022-3476(71)80161-0Suche in Google Scholar

82. Vesin S, Chudanova V. [Aortic aneurysm in Turner’s syndrome]. Ceskoslovenska Radiologie 1989;43:226–9.Suche in Google Scholar

83. Martin MM, Beekman RH, Rocchini AP, Crowley DC, Rosenthal A. Aortic aneurysms after subclavian angioplasty repair of coarctation of the aorta. Am J Cardiol 1988;61:951–3.10.1016/0002-9149(88)90390-6Suche in Google Scholar

84. Edwards WD, Leaf DS, Edwards JE. Dissecting aortic aneurysm associated with congenital bicuspid aortic valve. Circulation 1978;57:1022–5.10.1161/01.CIR.57.5.1022Suche in Google Scholar PubMed

85. Donadille B, Rousseau A, Zenaty D, Cabrol S, Courtillot C, et al. Cardiovascular findings and management in Turner syndrome: insights from a French cohort. Eur J Endocrinol 2012;167: 517–22.10.1530/EJE-12-0434Suche in Google Scholar PubMed

86. Loscalzo ML, Van PL, Ho VB, Bakalov VK, Rosing DR, et al. Association between fetal lymphedema and congenital cardiovascular defects in Turner syndrome. Pediatrics 2005;115: 732–5.10.1542/peds.2004-1369Suche in Google Scholar PubMed

87. Prandstraller D, Mazzanti L, Giardini A, Lovato L, Tamburrino F, et al. Correlations of phenotype and genotype in relation to morphologic remodelling of the aortic root in patients with Turner’s syndrome. Cardiol Young 2009;19:264–71.10.1017/S1047951109004016Suche in Google Scholar PubMed

88. Elsheikh M, Casadei B, Conway GS, Wass JA. Hypertension is a major risk factor for aortic root dilatation in women with Turner’s syndrome. Clin Endocrinol (Oxf) 2001;54:69–73.10.1046/j.1365-2265.2001.01154.xSuche in Google Scholar PubMed

89. Bryman I, Sylven L, Berntorp K, Innala E, Bergstrom I, et al. Pregnancy rate and outcome in Swedish women with Turner syndrome. Fertil Steril 2011;95:2507–10.10.1016/j.fertnstert.2010.12.039Suche in Google Scholar

90. Hadnott TN, Gould HN, Gharib AM, Bondy CA. Outcomes of spontaneous and assisted pregnancies in Turner syndrome: the U.S. National Institutes of Health experience. Fertil Steril 2011;95:2251–6.10.1016/j.fertnstert.2011.03.085Suche in Google Scholar

91. Hovatta O. Pregnancies in women with Turner’s syndrome. Ann Med 1999;31:106–10.10.3109/07853899908998785Suche in Google Scholar

92. Hagman A, Kallen K, Bryman I, Landin-Wilhelmsen K, Barrenas ML, et al. Morbidity and mortality after childbirth in women with Turner karyotype. Hum Reprod 2013;28:1961–73.10.1093/humrep/det113Suche in Google Scholar

93. Hagman A, Loft A, Wennerholm UB, Pinborg A, Bergh C, et al. Obstetric and neonatal outcome after oocyte donation in 106 women with Turner syndrome: a Nordic cohort study. Hum Reprod 2013;28:1598–609.10.1093/humrep/det082Suche in Google Scholar

94. Hagman A, Kallen K, Barrenas ML, Landin-Wilhelmsen K, Hanson C, et al. Obstetric outcomes in women with Turner karyotype. J Clin Endocrinol Metab 2011;96:3475–2.10.1210/jc.2011-1421Suche in Google Scholar

95. Karnis MF, Zimon AE, Lalwani SI, Timmreck LS, Klipstein S, et al. Risk of death in pregnancy achieved through oocyte donation in patients with Turner syndrome: a national survey. Fertil Steril 2003;80:498–501.10.1016/S0015-0282(03)00974-9Suche in Google Scholar

96. Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, et al. Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway. J Pathol 2009;218:131–42.10.1002/path.2516Suche in Google Scholar

97. Zhou J, Arepalli S, Cheng CM, Bakalov VK, Bondy CA. Perturbation of the transforming growth factor beta system in Turner syndrome. Beijing da xue xue bao Yi xue ban. Journal of Peking University Health Sciences 2012;44:720–4.Suche in Google Scholar

98. Lin AE, Lippe BM, Geffner ME, Gomes A, Lois JF, et al. Aortic dilation, dissection, and rupture in patients with Turner syndrome. J Pediatr 1986;109:820–6.10.1016/S0022-3476(86)80700-4Suche in Google Scholar

99. Cleemann L, Mortensen KH, Holm K, Smedegaard H, Skouby SO, et al. Aortic dimensions in girls and young women with turner syndrome: a magnetic resonance imaging study. Pediatr Cardiol 2010;31:497–504.10.1007/s00246-009-9626-8Suche in Google Scholar PubMed

100. Baxter L, Bryant J, Cave CB, Milne R. Recombinant growth hormone for children and adolescents with Turner syndrome. Cochrane Database Syst Rev 2007 (1):CD003887.10.1002/14651858.CD003887.pub2Suche in Google Scholar

101. Hughes IP, Choong CS, Harris M, Ambler GR, Cutfield WS, et al. Growth hormone treatment for Turner syndrome in Australia reveals that younger age and increased dose interact to improve response. Clin Endocrinol (Oxf) 2011;74:473–80.10.1111/j.1365-2265.2011.03937.xSuche in Google Scholar

102. Castillo C, Cruzado M, Ariznavarreta C, Gil-Loyzaga P, Lahera V, et al. Body composition and vascular effects of growth hormone administration in old female rats. Exp Gerontol 2003;38:971–9.10.1016/S0531-5565(03)00156-6Suche in Google Scholar

103. Erikstrup C, Pedersen LM, Heickendorff L, Ledet T, Rasmussen LM. Production of hyaluronan and chondroitin sulphate proteoglycans from human arterial smooth muscle—the effect of glucose, insulin, IGF-I or growth hormone. Eur 2001;145:193–8.10.1530/eje.0.1450193Suche in Google Scholar PubMed

104. Bondy CA, Van PL, Bakalov VK, Ho VB. Growth hormone treatment and aortic dimensions in Turner syndrome. J Clin Endocrinol Metab 2006;91:1785–8.10.1210/jc.2005-2625Suche in Google Scholar PubMed

105. Sharma J, Friedman D, Dave-Sharma S, Harbison M. Aortic distensibility and dilation in Turner’s syndrome. Cardiol Young 2009;19:568–72.10.1017/S1047951109990874Suche in Google Scholar PubMed

106. Sbarouni E, Georgiadou P, Marathias A, Geroulanos S, Kremastinos DT. D-dimer and BNP levels in acute aortic dissection. Int J Cardiol 2007;122:170–2.10.1016/j.ijcard.2006.11.056Suche in Google Scholar PubMed

107. Gutin LS, Bakalov VK, Rosing DR, Arai AE, Gharib AM, et al. N-terminal pro-brain natriuretic peptide levels and aortic diameters. Am Heart J 2012;164:419–24.10.1016/j.ahj.2012.06.021Suche in Google Scholar PubMed PubMed Central

108. Rochiccioli P, Battin J, Bertrand AM, Bost M, Cabrol S, et al. Final height in Turner syndrome patients treated with growth hormone. Horm Res 1995;44:172–6.10.1159/000184620Suche in Google Scholar PubMed

109. Rochiccioli P, David M, Malpuech G, Colle M, Limal JM, et al. Study of final height in Turner’s syndrome: ethnic and genetic influences. Acta Paediatr 1994;83:305–8.10.1111/j.1651-2227.1994.tb18099.xSuche in Google Scholar PubMed

110. Dawson-Falk KL, Wright AM, Bakker B, Pitlick PT, Wilson DM, et al. Cardiovascular evaluation in Turner syndrome: utility of MR imaging. Australas Radiol 1992;36:204–9.10.1111/j.1440-1673.1992.tb03152.xSuche in Google Scholar

111. Lopez L, Arheart KL, Colan SD, Stein NS, Lopez-Mitnik G, et al. Turner syndrome is an independent risk factor for aortic dilation in the young. Pediatrics 2008;121:e1622–7.10.1542/peds.2007-2807Suche in Google Scholar

112. Ostberg JE, Brookes JAS, McCarthy C, Halcox J, Conway GS. A comparison of echocardiography and magnetic resonance imaging in cardiovascular screening of adults with Turner syndrome. J Clin Endocrinol Metab 2004;89:5966–71.10.1210/jc.2004-1090Suche in Google Scholar

113. Davies RR, Goldstein LJ, Coady MA, Tittle SL, Rizzo JA, et al. Yearly rupture or dissection rates for thoracic aortic aneurysms: simple prediction based on size. Ann Thorac Surg 2002;73:17–27; discussion -8.10.1016/S0003-4975(01)03236-2Suche in Google Scholar

114. Schoenhoff FS, Cameron DE, Matyas G, Carrel TP. Cardiovasc Surg in Marfan syndrome: implications of new molecular concepts in thoracic aortic disease. Future Cardiol 2011;7:557–69.10.2217/fca.11.37Suche in Google Scholar PubMed

115. Kaiser T, Kellenberger CJ, Albisetti M, Bergstrasser E, Valsangiacomo Buechel ER. Normal values for aortic diameters in children and adolescents–assessment in vivo by contrast-enhanced CMR-angiography. J Cardiovasc Magn Reson 2008;10:56.10.1186/1532-429X-10-56Suche in Google Scholar PubMed PubMed Central

116. Davies RR, Gallo A, Coady MA, Tellides G, Botta DM, et al. Novel measurement of relative aortic size predicts rupture of thoracic aortic aneurysms. Ann Thorac Surg 2006;81:169–77.10.1016/j.athoracsur.2005.06.026Suche in Google Scholar PubMed

117. Lanzarini L, Larizza D, Prete G, Calcaterra V, Klersy C. Prospective evaluation of aortic dimensions in Turner syndrome: a 2-dimensional echocardiographic study. J Am Soc Echocardiogr 2007;20:307–13.10.1016/j.echo.2006.08.028Suche in Google Scholar PubMed

118. Mortensen KH, Hjerrild BE, Stochholm K, Andersen NH, Sorensen KE, et al. Dilation of the ascending aorta in Turner syndrome – a prospective cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 2011;13:24.10.1186/1532-429X-13-24Suche in Google Scholar PubMed PubMed Central

119. Mortensen KH, Erlandsen M, Andersen NH, Gravholt CH. Prediction of aortic dilation in Turner syndrome – enhancing the use of serial cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2013;15:47.10.1186/1532-429X-15-47Suche in Google Scholar PubMed PubMed Central

120. Burman ED, Keegan J, Kilner PJ. Aortic root measurement by cardiovascular magnetic resonance: specification of planes and lines of measurement and corresponding normal values. Circ Cardiovasc Imaging 2008;1:104–13.10.1161/CIRCIMAGING.108.768911Suche in Google Scholar

121. Castro AVBd, Okoshi K, Ribeiro SM, Barbosa MF, Mattos PF, et al. Cardiovascular assessment of patients with Ullrich-Turner’s syndrome on Doppler echocardiography and magnetic resonance imaging. Arq Bras Cardiol 2002;78:51–8.Suche in Google Scholar

122. Xiaocheng W, Zhaohui S, Ka B, Junhui X, Lei Z, et al. The expression of calcitonin gene-related Peptide and acetylcholine in the vestibular-related nucleus population of wild-type mice and retinal degeneration fast mice after rotary stimulation. J Mol Neurosci 2013;51:514–21.10.1007/s12031-013-0087-4Suche in Google Scholar

123. Ayad RF, Grayburn PA, Ko JM, Filardo G, Roberts WC. Accuracy of two-dimensional echocardiography in determining aortic valve structure in patients >50 years of age having aortic valve replacement for aortic stenosis. Am J Cardiol 2011;108: 1589–99.10.1016/j.amjcard.2011.09.006Suche in Google Scholar

124. Brandenburg RO, Jr., Tajik AJ, Edwards WD, Reeder GS, Shub C, et al. Accuracy of 2-dimensional echocardiographic diagnosis of congenitally bicuspid aortic valve: echocardiographic-anatomic correlation in 115 patients. Am J Cardiol 1983;51:1469–73.10.1016/0002-9149(83)90659-8Suche in Google Scholar

125. Chan KL, Stinson WA, Veinot JP. Reliability of transthoracic echocardiography in the assessment of aortic valve morphology: pathological correlation in 178 patients. Can J Cardiol 1999;15:48–2.Suche in Google Scholar

126. Malaisrie SC, Carr J, Mikati I, Rigolin V, Yip BK, et al. Cardiac magnetic resonance imaging is more diagnostic than 2-dimensional echocardiography in determining the presence of bicuspid aortic valve. J Thorac Cardiovasc Surg 2012;144:370–6.10.1016/j.jtcvs.2011.09.068Suche in Google Scholar

127. Roberts WC. The congenitally bicuspid aortic valve. A study of 85 autopsy cases. Am J Cardiol 1970;26:72–83.10.1016/0002-9149(70)90761-7Suche in Google Scholar

128. Lanzarini L, Larizza D, Prete G, Calcaterra V, Meloni G, et al. Aortic dimensions in Turner’s syndrome: two-dimensional echocardiography versus magnetic resonance imaging. J Cardiovasc Med (Hagerstown) 2007;8:428–37.10.2459/01.JCM.0000269716.33435.d3Suche in Google Scholar PubMed

129. Hiratzka LF, Bakris GL, Beckman JA, Bersin RM, Carr VF, et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation 2010;121:e266–369.Suche in Google Scholar

130. Chalas Boissonnas C, Davy C, Marszalek A, Duranteau L, de Ziegler D, et al. Cardiovascular findings in women suffering from Turner syndrome requesting oocyte donation. Hum Reprod 2011;26:2754–62.10.1093/humrep/der262Suche in Google Scholar PubMed

131. Akyurek N, Atabek ME, Eklioglu BS, Alp H. Ambulatory blood pressure and subclinical cardiovascular disease in children with Turner syndrome. Pediatr Cardiol 2014;35:57–62.10.1007/s00246-013-0740-2Suche in Google Scholar PubMed

132. Freriks K, Timmermans J, Beerendonk CC, Verhaak CM, Netea-Maier RT, et al. Standardized multidisciplinary evaluation yields significant previously undiagnosed morbidity in adult women with Turner syndrome. J Clin Endocrinol Metab 2011;96:E1517–26.10.1210/jc.2011-0346Suche in Google Scholar PubMed

133. Giordano R, Forno D, Lanfranco F, Manieri C, Ghizzoni L, et al. Metabolic and cardiovascular outcomes in a group of adult patients with Turner’s syndrome under hormonal replacement therapy. Eur J Endocrinol 2011;164:819–26.10.1530/EJE-11-0002Suche in Google Scholar PubMed

134. Bondy CA, Ceniceros I, Van PL, Bakalov VK, Rosing DR. Prolonged rate-corrected QT interval and other electrocardiogram abnormalities in girls with Turner syndrome. Pediatrics 2006;118:e1220–5.10.1542/peds.2006-0776Suche in Google Scholar PubMed

135. Bondy CA, Van PL, Bakalov VK, Sachdev V, Malone CA, et al. Prolongation of the cardiac QTc interval in Turner syndrome. Medicine 2006;85:75–81.10.1097/01.md.0000205629.16302.bcSuche in Google Scholar PubMed

136. Practice Committee of American Society For Reproductive Medicine. Increased maternal cardiovascular mortality associated with pregnancy in women with Turner syndrome. Fertil Steril 2012;97:282–4.Suche in Google Scholar

137. Cabanes L, Chalas C, Christin-Maitre S, Donadille B, Felten ML, et al. Turner syndrome and pregnancy: clinical practice. Recommendations for the management of patients with Turner syndrome before and during pregnancy. Eur J Obstet Gynecol Reprod Biol 2010;152:18–24.10.1016/j.ejogrb.2010.05.019Suche in Google Scholar PubMed

138. Cook JR, Nistala H, Ramirez F. Drug-based therapies for vascular disease in Marfan syndrome: from mouse models to human patients. Mt Sinai J Med 2010;77:366–73.10.1002/msj.20200Suche in Google Scholar PubMed PubMed Central

139. Hartog AW, Franken R, Zwinderman AH, Groenink M, Mulder BJM. Current and future pharmacological treatment strategies with regard to aortic disease in Marfan syndrome. Expert Opin Pharmacother 2012;13:647–62.10.1517/14656566.2012.665446Suche in Google Scholar PubMed

140. Peng H, Carretero OA, Vuljaj N, Liao T-D, Motivala A, et al. Angiotensin-converting enzyme inhibitors: a new mechanism of action. Circulation 2005;112:2436–45.10.1161/CIRCULATIONAHA.104.528695Suche in Google Scholar PubMed PubMed Central

141. Ahimastos AA, Aggarwal A, D’Orsa KM, Formosa MF, White AJ, et al. Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial. J Am Med Assoc 2007;298:1539–47.10.1001/jama.298.13.1539Suche in Google Scholar PubMed

142. Brooke BS, Habashi JP, Judge DP, Patel N, Loeys B,et al. Angiotensin II blockade and aortic-root dilation in Marfan’s syndrome. N Engl J Med 2008;358:2787–95.10.1056/NEJMoa0706585Suche in Google Scholar PubMed PubMed Central

143. Kataoka K, Ozawa A, Inage A, Benson LN. Transcatheter repair of native coarctation in children with Turner syndrome: three case reports and literature review. Congenit 2006;1:315–20.10.1111/j.1747-0803.2006.00054.xSuche in Google Scholar PubMed

144. Devernay M, Ecosse E, Coste J, Carel J-C. Determinants of medical care for young women with Turner syndrome. J Clin Endocrinol Metab 2009;94:3408–13.10.1210/jc.2009-0495Suche in Google Scholar PubMed

Received: 2013-11-3
Accepted: 2014-4-17
Published Online: 2014-5-31
Published in Print: 2014-11-1

©2014 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Cardiovascular disease and prevention
  4. Reviews
  5. Future orientation: a construct with implications for adolescent health and wellbeing
  6. Aortic dilatation and dissection in Turner syndrome: What we know, what we are unclear about and what we should do in clinical practice?
  7. Original articles
  8. Gender differences in early trauma and high-risk behaviors among street-entrenched youth in British Columbia
  9. Health-promoting lifestyle and its predictors among Iranian adolescent girls, 2013
  10. Health risk behaviors and sexual initiation among in-school adolescents in rural communities in southwestern Nigeria
  11. Is change in health behavior of Dutch medical students related to change in their ideas on how a physician’s lifestyle influences their patient’s lifestyle?
  12. Awareness of current recommendations and guidelines regarding strength training for youth
  13. Non-medical prescription drug and illicit street drug use among young Swiss men and associated mental health issues
  14. Prevalence of health behaviors and their associated factors among a sample of university students in India
  15. Quality of life measures and psychiatric symptoms in adolescents with systemic lupus erythematosus and familial Mediterranean fever
  16. Risk behaviors related to violence and injury among school-going adolescents in Karnataka, Southern India
  17. Polycystic ovary syndrome in Iranian adolescents
  18. Relational stressors as predictors for repeat aggressive and self-harming incidents in child and adolescent psychiatric inpatient settings
  19. Effect of life skills training on physical activity patterns amongst school adolescents in Delhi: a non-randomized interventional study
  20. Association of oral hygiene habits and food intake with the risk of dental caries among undergraduate university women in Saudi Arabia
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