Dyslipidemia and hyperinsulinemia in children and adolescents with chronic liver disease: relation to disease severity
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Zeinab A. El-Kabbany
,
Salwa AH. Ibrahim
Abstract
Background: Lipid metabolism is profoundly disturbed in chronic liver diseases (CLD). Moreover, patients with cirrhosis displayed chronically elevated serum insulin (SI) concentrations.
Objectives: The aim of this work was to assess fasting lipid profile (FLP) and SI levels among Egyptian patients with CLD and their relation to severity of liver disease.
Methods: A total of 40 Egyptian children with CLD were compared with 30 age-, sex-, and pubertal stage-matched controls. All subjects were subjected to history and auxological assessment; their FLP, fasting blood glucose (FBG) and SI were measured; and their fasting glucose/insulin (G/I) ratios were calculated.
Results: Total cholesterol (TC, p=0.006), triglycerides (TG, p=0.03), low density lipoproteins (LDL, p=0.034), and SI (p<0.001) were significantly higher while high density lipoproteins (HDL, p<0.001) and G/I ratio (p<0.001) were significantly lower as serum albumin decreased; these were also lower among cases with a progressive decrease going from child A to C. Of the 40 studied cases, eight (20%) had hypercholesterolemia, 13 (32.5%) had hypertriglyceridemia, 17 (42.5%) had low HDL and 9 (22.5%) had high LDL, 32 (80%) had hyperinsulinemia (HI), and 11 (27.5%) had insulin resistance (IR).
Conclusions: Dyslipidemia and HI were frequent findings in patients with CLD, which worsened with increased severity of CLD.
Acknowledgments
The authors declare no financial support.
Conflict of interest statement: None.
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- Original articles
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- Dyslipidemia and hyperinsulinemia in children and adolescents with chronic liver disease: relation to disease severity
- A cross-national study to compare the knowledge, attitudes, perceptions of sexually transmitted diseases and the sexual risk behaviors of Latino adolescents
- University students and the risk of HIV and other sexually transmitted infections in Uganda: The Crane Survey
- Concurrent and simultaneous polydrug use among young Swiss males: use patterns and associations of number of substances used with health issues
- Sexual behavior of in-school adolescents in Osun State, Southwest Nigeria: a comparative study
- Health profile of urban adolescent girls from India
- Age of first reported sexual experience among U.S. soldiers
- Prehypertension and associated factors among university students in the Philippines
- School-based intervention to promote healthy nutrition in Sousse, Tunisia
- Awareness, acceptability, and use of female condoms among university students in Nigeria: implications for STI/HIV prevention
- Clustering of risk factors in the smoking habits of schoolchildren in Sousse, Tunisia
- Self-esteem in adolescents with chronic physical illness vs. controls in Northern Russia
- Gender differences in the mental health literacy of young people
- Case reports
- An adolescent with chronic giardiasis mimicking anorexia nervosa
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- Book Review
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