Extracellular stimulation of lung fibroblasts with arachidonic acid increases interleukin 11 expression through p38 and ERK signaling

References

Alexander, L.D., Cui, X.L., Falck, J.R., and Douglas, J.G. (2001). Arachidonic acid directly activates members of the mitogen-activated protein kinase superfamily in rabbit proximal tubule cells. Kidney Int. 59: 2039–2053. https://doi.org/10.1046/j.1523-1755.2001.00718.x.Search in Google Scholar PubMed

Alsabeeh, N., Chausse, B., Kakimoto, P.A., Kowaltowski, A.J., and Shirihai, O. (2018). Cell culture models of fatty acid overload: problems and solutions. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1863: 143–151. https://doi.org/10.1016/j.bbalip.2017.11.006.Search in Google Scholar PubMed PubMed Central

Bamba, S., Andoh, A., Yasui, H., Makino, J., Kim, S., and Fujiyama, Y. (2003). Regulation of IL-11 expression in intestinal myofibroblasts: role of c-Jun AP-1- and MAPK-dependent pathways. Am. J. Physiol. Gastrointest. Liver Physiol. 285: G529–G538. https://doi.org/10.1152/ajpgi.00050.2003.Search in Google Scholar PubMed

Brock, T.G., McNish, R.W., and Peters-Golden, M. (1999). Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2. J. Biol. Chem. 274: 11660–11666. https://doi.org/10.1074/jbc.274.17.11660.Search in Google Scholar PubMed

Bryan, D.-L., Forsyth, K.D., Hart, P.H., and Gibson, R.A. (2006). Polyunsaturated fatty acids regulate cytokine and prostaglandin E2 production by respiratory cells in response to mast cell mediators. Lipids 41: 1101–1107. https://doi.org/10.1007/s11745-006-5059-9.Search in Google Scholar PubMed

Chang, L. and Karin, M. (2001). Mammalian MAP kinase signalling cascades. Nature 410: 37–40. https://doi.org/10.1038/35065000.Search in Google Scholar PubMed

Cook, S.A. and Schafer, S. (2020). Hiding in plain sight: interleukin-11 emerges as a master regulator of fibrosis, tissue integrity, and stromal inflammation. Annu. Rev. Med. 71: 263–276. https://doi.org/10.1146/annurev-med-041818-011649.Search in Google Scholar PubMed

Dietze, R., Hammoud, M.K., Gómez-Serrano, M., Unger, A., Bieringer, T., Finkernagel, F., Sokol, A.M., Nist, A., Stiewe, T., Reinartz, S., et al.. (2021). Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer. Theranostics 11: 1377–1395. https://doi.org/10.7150/thno.52442.Search in Google Scholar PubMed PubMed Central

Dimitriadis, E., Stoikos, C., Baca, M., Fairlie, W.D., McCoubrie, J.E., and Salamonsen, L.A. (2005). Relaxin and prostaglandin E(2) regulate interleukin 11 during human endometrial stromal cell decidualization. J. Clin. Endocrinol. Metab. 90: 3458–3465. https://doi.org/10.1210/jc.2004-1014.Search in Google Scholar PubMed

Dong, J., Viswanathan, S., Adami, E., Singh, B.K., Chothani, S.P., Ng, B., Lim, W.W., Zhou, J., Tripathi, M., Ko, N.S.J., et al.. (2021). Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nat. Commun. 12: 66. https://doi.org/10.1038/s41467-020-20303-z.Search in Google Scholar PubMed PubMed Central

Fujisawa, Y., Matsuda, K., and Uehara, T. (2020). Osteopontin enhances the migration of lung fibroblasts via upregulation of interleukin-6 through the extracellular signal-regulated kinase (ERK) pathway. Biol. Chem. 401: 1071–1080. https://doi.org/10.1515/hsz-2020-0125.Search in Google Scholar PubMed

Fung, K.Y., Louis, C., Metcalfe, R.D., Kosasih, C.C., Wicks, I.P., Griffin, M.D.W., and Putoczki, T.L. (2022). Emerging roles for IL-11 in inflammatory diseases. Cytokine 149: 155750. https://doi.org/10.1016/j.cyto.2021.155750.Search in Google Scholar PubMed

Garbers, C. and Scheller, J. (2013). Interleukin-6 and interleukin-11: same same but different. Biol. Chem. 394: 1145–1161. https://doi.org/10.1515/hsz-2013-0166.Search in Google Scholar PubMed

Garcia, M.C., Ray, D.M., Lackford, B., Rubino, M., Olden, K., and Roberts, J.D. (2009). Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27. J. Biol. Chem. 284: 20936–20945. https://doi.org/10.1074/jbc.m109.020271.Search in Google Scholar PubMed PubMed Central

Guijas, C., Pérez-Chacón, G., Astudillo, A.M., Rubio, J.M., Gil-de-Gómez, L., Balboa, M.A., and Balsinde, J. (2012). Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes. J. Lipid Res. 53: 2343–2354. https://doi.org/10.1194/jlr.m028423.Search in Google Scholar

Guo, L., Lai, Z., Wang, Y., and Li, Z. (2020). In situ probing changes in fatty-acyl chain length and desaturation of lipids in cancerous areas using mass spectrometry imaging. J. Mass Spectrom. 56: e4621. https://doi.org/10.1002/jms.4621.Search in Google Scholar PubMed

Gupta, J., Robbins, J., Jilling, T., and Seth, P. (2011). TGFβ-dependent induction of interleukin-11 and interleukin-8 involves SMAD and p38 MAPK pathways in breast tumor models with varied bone metastases potential. Cancer Biol. Ther. 11: 311–316. https://doi.org/10.4161/cbt.11.3.14096.Search in Google Scholar PubMed PubMed Central

Hii, C.S., Huang, Z.H., Bilney, A., Costabile, M., Murray, A.W., Rathjen, D.A., Der, C.J., and Ferrante, A. (1998). Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type-specific activation of mitogen-activated protein kinases. J. Biol. Chem. 273: 19277–19282. https://doi.org/10.1074/jbc.273.30.19277.Search in Google Scholar PubMed

Hoang, B., Trinh, A., Birnbaumer, L., and Edwards, R.A. (2007). Decreased MAPK- and PGE2-dependent IL-11 production in Giα2−/− colonic myofibroblasts. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G1511–G1519. https://doi.org/10.1152/ajpgi.00307.2006.Search in Google Scholar PubMed

Huang, S., Wettlaufer, S.H., Hogaboam, C., Aronoff, D.M., and Peters-Golden, M. (2007). Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling. Am. J. Physiol. Lung Cell Mol. Physiol. 292: L405–L413. https://doi.org/10.1152/ajplung.00232.2006.Search in Google Scholar PubMed

Jianyong, Z., Yanruo, H., Xiaoju, T., Yiping, W., and Fengming, L. (2021). Roles of lipid profiles in human non-small cell lung cancer. Technol. Cancer Res. Treat. 20: 15330338211041472. https://doi.org/10.1177/15330338211041472.Search in Google Scholar PubMed PubMed Central

Kaps, L. and Schuppan, D. (2020). Targeting cancer associated fibroblasts in liver fibrosis and liver cancer using nanocarriers. Cells 9: 2027. https://doi.org/10.3390/cells9092027.Search in Google Scholar PubMed PubMed Central

Kirk, T., Ahmed, A. and Rognoni, E. (2021). Fibroblast memory in development, homeostasis and disease. Cells 10: 2840. https://doi.org/10.3390/cells10112840.Search in Google Scholar PubMed PubMed Central

Kortekaas, R.K., Burgess, J.K., van Orsoy, R., Lamb, D., Webster, M., and Gosens, R. (2021). Therapeutic targeting of IL-11 for chronic lung disease. Trends Pharmacol. Sci. 42: 354–366. https://doi.org/10.1016/j.tips.2021.01.007.Search in Google Scholar PubMed

Lecureur, V., Arzel, M., Ameziane, S., Houlbert, N., Le Vee, M., Jouneau, S., and Fardel, O. (2012). MAPK- and PKC/CREB-dependent induction of interleukin-11 by the environmental contaminant formaldehyde in human bronchial epithelial cells. Toxicology 292: 13–22. https://doi.org/10.1016/j.tox.2011.11.011.Search in Google Scholar PubMed

Li, Y.J., Wang, X.Q., Sato, T., Kanaji, N., Nakanishi, M., Kim, M., Michalski, J., Nelson, A.J., Sun, J.H., Farid, M., et al.. (2011). Prostaglandin E2 inhibits human lung fibroblast chemotaxis through disparate actions on different E-prostanoid receptors. Am. J. Respir. Cell Mol. Biol. 44: 99–107. https://doi.org/10.1165/rcmb.2009-0163oc.Search in Google Scholar

Liu, J., Mazzone, P.J., Cata, J.P., Kurz, A., Bauer, M., Mascha, E.J., and Sessler, D.I. (2014). Serum free fatty acid biomarkers of lung cancer. Chest 146: 670–679. https://doi.org/10.1378/chest.13-2568.Search in Google Scholar PubMed

Liu, Y., Lin, J., Chen, Y., Li, Z., Zhou, J., Lu, X., Chen, Z., and Zuo, D. (2021). Omega-3 polyunsaturated fatty acids inhibit IL-11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity. Int. J. Mol. Med. 48: 190. https://doi.org/10.3892/ijmm.2021.5023.Search in Google Scholar PubMed PubMed Central

Matsui, S., Yamashita, N., Mino, T., Taki, H., Sugiyama, E., Hayashi, R., Maruyama, M., and Kobayashi, M. (1999). Role of the endogenous prostaglandin E2 in human lung fibroblast interleukin-11 production. Respir. Med. 93: 637–642. https://doi.org/10.1016/s0954-6111(99)90103-8.Search in Google Scholar PubMed

Matsumoto, H., Naraba, H., Murakami, M., Kudo, I., Yamaki, K., Ueno, A., and Oh-ishi, S. (1997). Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. Biochem. Biophys. Res. Commun. 230: 110–114. https://doi.org/10.1006/bbrc.1996.5894.Search in Google Scholar PubMed

Meng, H., Shen, Y., Shen, J., Zhou, F., Shen, S., and Das, U.N. (2013). Effect of n-3 and n-6 unsaturated fatty acids on prostate cancer (PC-3) and prostate epithelial (RWPE-1) cells in vitro. Lipids Health Dis. 12: 160. https://doi.org/10.1186/1476-511x-12-160.Search in Google Scholar

Metcalfe, R.D., Putoczki, T.L., and Griffin, M.D.W. (2020). Structural understanding of interleukin 6 family cytokine signaling and targeted therapies: focus on interleukin 11. Front. Immunol. 11: 1424. https://doi.org/10.3389/fimmu.2020.01424.Search in Google Scholar PubMed PubMed Central

Mino, T., Sugiyama, E., Taki, H., Kuroda, A., Yamashita, N., Maruyama, M., and Kobayashi, M. (1998). Interleukin-1alpha and tumor necrosis factor alpha synergistically stimulate prostaglandin E2-dependent production of interleukin-11 in rheumatoid synovial fibroblasts. Arthritis Rheum. 41: 2004–2013. https://doi.org/10.1002/1529-0131(199811)41:11<2004::aid-art16>3.0.co;2-z.10.1002/1529-0131(199811)41:11<2004::AID-ART16>3.0.CO;2-ZSearch in Google Scholar

Morrison, D.K. (2012). MAP kinase pathways. Cold Spring Harbor Perspect. Biol. 4: a011254. https://doi.org/10.1101/cshperspect.a011254.Search in Google Scholar

Navarro-Tito, N., Robledo, T., and Salazar, E.P. (2008). Arachidonic acid promotes FAK activation and migration in MDA-MB-231 breast cancer cells. Exp. Cell Res. 314: 3340–3355. https://doi.org/10.1016/j.yexcr.2008.08.018.Search in Google Scholar

Ng, B., Dong, J., D’Agostino, G., Viswanathan, S., Widjaja, A.A., Lim, W.W., Ko, N.S.J., Tan, J., Chothani, S.P., Huang, B., et al.. (2019). Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis. Sci. Transl. Med. 11: eaaw1237. https://doi.org/10.1126/scitranslmed.aaw1237.Search in Google Scholar

Ng, B., Dong, J., Viswanathan, S., Widjaja, A.A., Paleja, B.S., Adami, E., Ko, N.S.J., Wang, M., Lim, S., Tan, J., et al.. (2020). Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease. Faseb. J. 34: 11802–11815. https://doi.org/10.1096/fj.202001045rr.Search in Google Scholar

Nishina, T., Deguchi, Y., Ohshima, D., Takeda, W., Ohtsuka, M., Shichino, S., Ueha, S., Yamazaki, S., Kawauchi, M., Nakamura, E., et al.. (2021). Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat. Commun. 12: 2281. https://doi.org/10.1038/s41467-021-22450-3.Search in Google Scholar

Nørregaard, R., Kwon, T.-H., and Frøkiær, J. (2015). Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney. Kidney Res. Clin. Pract. 34: 194–200.10.1016/j.krcp.2015.10.004Search in Google Scholar

Oh, E., Yun, M., Kim, S.K., Seo, G., Bae, J.S., Joo, K., Chae, G.T., and Lee, S.-B. (2014). Palmitate induces COX-2 expression via the sphingolipid pathway-mediated activation of NF-κB, p38, and ERK in human dermal fibroblasts. Arch. Dermatol. Res. 306: 339–345. https://doi.org/10.1007/s00403-013-1434-6.Search in Google Scholar

Oyesanya, R.A., Lee, Z.P., Wu, J., Chen, J., Song, Y., Mukherjee, A., Dent, P., Kordula, T., Zhou, H., and Fang, X. (2008). Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells. Faseb. J. 22: 2639–2651. https://doi.org/10.1096/fj.07-101428.Search in Google Scholar PubMed PubMed Central

Paine, E., Palmantier, R., Akiyama, S.K., Olden, K., and Roberts, J.D. (2000). Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway. J. Biol. Chem. 275: 11284–11290. https://doi.org/10.1074/jbc.275.15.11284.Search in Google Scholar PubMed

Piersma, B., Hayward, M.K., and Weaver, V.M. (2020). Fibrosis and cancer: a strained relationship. Biochim. Biophys. Acta Rev. Canc 1873: 188356. https://doi.org/10.1016/j.bbcan.2020.188356.Search in Google Scholar PubMed PubMed Central

Rajgopal, R., Butcher, M., Weitz, J.I., and Shaughnessy, S.G. (2006). Heparin synergistically enhances interleukin-11 signaling through up-regulation of the MAPK pathway. J. Biol. Chem. 281: 20780–20787. https://doi.org/10.1074/jbc.m600169200.Search in Google Scholar

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D.G., Egeblad, M., Evans, R.M., Fearon, D., Greten, F.R., Hingorani, S.R., Hunter, T., et al.. (2020). A framework for advancing our understanding of cancer-associated fibroblasts. Nat. Rev. Cancer 20: 174–186. https://doi.org/10.1038/s41568-019-0238-1.Search in Google Scholar PubMed PubMed Central

Samarelli, A.V., Masciale, V., Aramini, B., Coló, G.P., Tonelli, R., Marchioni, A., Bruzzi, G., Gozzi, F., Andrisani, D., Castaniere, I., et al.. (2021). Molecular mechanisms and cellular contribution from lung fibrosis to lung cancer development. Int. J. Mol. Sci. 22: 12179. https://doi.org/10.3390/ijms222212179.Search in Google Scholar PubMed PubMed Central

Shimodaira, T., Matsuda, K., Uchibori, T., Sugano, M., Uehara, T., and Honda, T. (2018). Upregulation of osteopontin expression via the interaction of macrophages and fibroblasts under IL-1β stimulation. Cytokine 110: 63–69, https://doi.org/10.1016/j.cyto.2018.04.025.Search in Google Scholar PubMed

Suryadevara, V., Ramchandran, R., Kamp, D.W., and Natarajan, V. (2020). Lipid mediators regulate pulmonary fibrosis: potential mechanisms and signaling pathways. Int. J. Mol. Sci. 21: 4257. https://doi.org/10.3390/ijms21124257.Search in Google Scholar PubMed PubMed Central

Taki, H., Sugiyama, E., Mino, T., Kuroda, A., and Kobayashi, M. (1998). Differential inhibitory effects of indomethacin, dexamethasone, and interferon-gamma (IFN-γ) on IL-11 production by rheumatoid synovial cells. Clin. Exp. Immunol. 112: 133–138. https://doi.org/10.1046/j.1365-2249.1998.00552.x.Search in Google Scholar PubMed PubMed Central

Villegas-Comonfort, S., Serna-Marquez, N., Galindo-Hernandez, O., Navarro-Tito, N., and Salazar, E.P. (2012). Arachidonic acid induces an increase of β-1,4-galactosyltransferase I expression in MDA-MB-231 breast cancer cells. J. Cell. Biochem. 113: 3330–3341. https://doi.org/10.1002/jcb.24209.Search in Google Scholar PubMed

Villegas-Comonfort, S., Castillo-Sanchez, R., Serna-Marquez, N., Cortes-Reynosa, P., and Salazar, E.P. (2014). Arachidonic acid promotes migration and invasion through a PI3K/Akt-dependent pathway in MDA-MB-231 breast cancer cells. Prostaglandins Leukot. Essent. Fatty Acids 90: 169–177. https://doi.org/10.1016/j.plefa.2014.01.007.Search in Google Scholar PubMed

Wang, X., Che, X., Liu, C., Fan, Y., Bai, M., Hou, K., Shi, X., Zhang, X., Liu, B., Zheng, C., et al.. (2018). Cancer-associated fibroblasts-stimulated interleukin-11 promotes metastasis of gastric cancer cells mediated by upregulation of MUC1. Exp. Cell Res. 368: 184–193. https://doi.org/10.1016/j.yexcr.2018.04.028.Search in Google Scholar PubMed

Wei, L., Wu, Z., and Chen, Y.Q. (2022). Multi-targeted therapy of cancer by omega-3 fatty acids-an update. Cancer Lett. 526: 193–204. https://doi.org/10.1016/j.canlet.2021.11.023.Search in Google Scholar PubMed

White, E.S., Atrasz, R.G., Dickie, E.G., Aronoff, D.M., Stambolic, V., Mak, T.W., Moore, B.B., and Peters-Golden, M. (2005). Prostaglandin E2 inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity. Am. J. Respir. Cell Mol. Biol. 32: 135–141. https://doi.org/10.1165/rcmb.2004-0126oc.Search in Google Scholar

White, K.E., Ding, Q., Moore, B.B., Peters-Golden, M., Ware, L.B., Matthay, M.A., and Olman, M.A. (2008). Prostaglandin E2 mediates IL-1β-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J. Immunol. 180: 637–646. https://doi.org/10.4049/jimmunol.180.1.637.Search in Google Scholar PubMed PubMed Central

Widjaja, A.A., Singh, B.K., Adami, E., Viswanathan, S., Dong, J., D’Agostino, G.A., Ng, B., Lim, W.W., Tan, J., Paleja, B.S., et al.. (2019). Inhibiting interleukin 11 signaling reduces hepatocyte death and liver fibrosis, inflammation, and steatosis in mouse models of nonalcoholic steatohepatitis. Gastroenterology 157: 777–792.e14. https://doi.org/10.1053/j.gastro.2019.05.002.Search in Google Scholar PubMed

Widjaja, A.A., Chothani, S.P., and Cook, S.A. (2020). Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy. Hum. Vaccines Immunother. 16: 2357–2362. https://doi.org/10.1080/21645515.2020.1761203.Search in Google Scholar PubMed PubMed Central

Widjaja, A.A., Viswanathan, S., Jinrui, D., Singh, B.K., Tan, J., Wei Ting, J.G., Lamb, D., Shekeran, S.G., George, B.L., Schafer, S., et al.. (2021). Molecular dissection of pro-fibrotic IL11 signaling in cardiac and pulmonary fibroblasts. Front. Mol. Biosci. 8: 740650. https://doi.org/10.3389/fmolb.2021.740650.Search in Google Scholar PubMed PubMed Central

Wu, F., Yang, J., Liu, J., Wang, Y., Mu, J., Zeng, Q., Deng, S., and Zhou, H. (2021). Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer. Signal Transduct. Targeted Ther. 6: 218. https://doi.org/10.1038/s41392-021-00641-0.Search in Google Scholar PubMed PubMed Central

Xin, C., Chu, L., Zhang, L., Geng, D., Wang, Y., Sun, D., Sui, P., Zhao, X., Gong, Z., Sui, M., et al.. (2019). Expression of cytosolic phospholipase A2 (cPLA2)-arachidonic acid (AA)-cyclooxygenase-2 (COX-2) pathway factors in lung cancer patients and its implication in lung cancer early detection and prognosis. Med. Sci. Monit. Int. Med. J. Exp. Clin. Res. 25: 5543–5551. https://doi.org/10.12659/msm.915314.Search in Google Scholar PubMed PubMed Central

Xu, D.H., Zhu, Z., Wakefield, M.R., Xiao, H., Bai, Q., and Fang, Y. (2016). The role of IL-11 in immunity and cancer. Cancer Lett. 373: 156–163. https://doi.org/10.1016/j.canlet.2016.01.004.Search in Google Scholar PubMed

Yamazumi, K., Nakayama, T., Kusaba, T., Wen, C.Y., Yoshizaki, A., Yakata, Y., Nagayasu, T., and Sekine, I. (2006). Expression of interleukin-11 and interleukin-11 receptor α in human colorectal adenocarcinoma; immunohistochemical analyses and correlation with clinicopathological factors. World J. Gastroenterol. 12: 317–321. https://doi.org/10.3748/wjg.v12.i2.317.Search in Google Scholar PubMed PubMed Central

Yoshida, K., Shinohara, H., Haneji, T., and Nagata, T. (2007). Arachidonic acid inhibits osteoblast differentiation through cytosolic phospholipase A2-dependent pathway. Oral Dis. 13: 32–39. https://doi.org/10.1111/j.1601-0825.2006.01239.x.Search in Google Scholar PubMed

Zhang, L., Han, L., He, J., Lv, J., Pan, R., and Lv, T. (2020). A high serum-free fatty acid level is associated with cancer. J. Cancer Res. Clin. Oncol. 146: 705–710. https://doi.org/10.1007/s00432-019-03095-8.Search in Google Scholar PubMed PubMed Central

Zhang, N., Wang, L., Luo, G., Tang, X., Ma, L., Zheng, Y., Liu, S., C, A.P., and Jiang, Z. (2019). Arachidonic acid regulation of intracellular signaling pathways and target gene expression in bovine ovarian granulosa cells. Animals 9: 374, https://doi.org/10.3390/ani9060374.Search in Google Scholar PubMed PubMed Central

Zhao, Z.A., Zhang, Z.R., Xu, X., Deng, W.B., Li, M., Leng, J.Y., Liang, X.H., and Yang, Z.M. (2012). Arachidonic acid regulation of the cytosolic phospholipase A 2α/cyclooxygenase-2 pathway in mouse endometrial stromal cells. Fertil. Steril. 97: 1199. https://doi.org/10.1016/j.fertnstert.2012.02.011.Search in Google Scholar PubMed

Zhu, B., Zhang, J., Zheng, Q., Dong, B., Wang, M., Liu, J., and Cao, Y. (2021). Free fatty acid is a promising biomarker in triage screening for patients with colorectal cancer: a case-control study. Cancer Manag. Res. 13: 3749–3759. https://doi.org/10.2147/cmar.s307753.Search in Google Scholar PubMed PubMed Central