Abstract
The role of proteases in cancer was originally thought to be limited to the breakdown of basement membranes and extracellular matrix (ECM), thereby promoting cancer cell invasion into surrounding normal tissues. It is now well understood that proteases play a much more complicated role in all stages of cancer progression and that not only tumor cells, but also stromal cells are an important source of proteases in the tumor microenvironment. Among all the proteolytic enzymes potentially associated with cancer, some proteases have taken on heightened importance due to their significant up-regulation and ability to participate at multiple stages of cancer progression and metastasis. In this review, we discuss some of the advances in understanding of the roles of several key proteases from different classes in the development and progression of cancer and the potential to leverage their upregulated activity for the development of novel targeted treatment strategies.
Acknowledgments
The authors gratefully acknowledge W. Michael Kavanaugh for the critical review of the manuscript. Probody™ is a trademark of CytomX Therapeutics, Inc.
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© 2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- The multifaceted roles of tumor-associated proteases and harnessing their activity for prodrug activation
- Retrograde response by reactive oxygen/nitrogen species in plants involving different cellular organelles
- Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function
- STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases
- Research Articles/Short Communications
- Cell Biology and Signaling
- Zinc-induced activation of GPR39 regulates glucose homeostasis through glucose-dependent insulinotropic polypeptide secretion from enteroendocrine K-cells
- Long non-coding RNA CHRF promotes proliferation and mesenchymal transition (EMT) in prostate cancer cell line PC3 requiring up-regulating microRNA-10b
- LncRNA DYNLRB2-2 inhibits THP-1 macrophage foam cell formation by enhancing autophagy
- Geniposide alleviates lipopolysaccharide (LPS)-induced inflammation by downregulation of miR-27a in rat pancreatic acinar cell AR42J
- Tripterine inhibits proliferation, migration and invasion of breast cancer MDA-MB-231 cells by up-regulating microRNA-15a
- miR-99b-3p is induced by vitamin D3 and contributes to its antiproliferative effects in gastric cancer cells by targeting HoxD3
Articles in the same Issue
- Frontmatter
- Reviews
- The multifaceted roles of tumor-associated proteases and harnessing their activity for prodrug activation
- Retrograde response by reactive oxygen/nitrogen species in plants involving different cellular organelles
- Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function
- STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases
- Research Articles/Short Communications
- Cell Biology and Signaling
- Zinc-induced activation of GPR39 regulates glucose homeostasis through glucose-dependent insulinotropic polypeptide secretion from enteroendocrine K-cells
- Long non-coding RNA CHRF promotes proliferation and mesenchymal transition (EMT) in prostate cancer cell line PC3 requiring up-regulating microRNA-10b
- LncRNA DYNLRB2-2 inhibits THP-1 macrophage foam cell formation by enhancing autophagy
- Geniposide alleviates lipopolysaccharide (LPS)-induced inflammation by downregulation of miR-27a in rat pancreatic acinar cell AR42J
- Tripterine inhibits proliferation, migration and invasion of breast cancer MDA-MB-231 cells by up-regulating microRNA-15a
- miR-99b-3p is induced by vitamin D3 and contributes to its antiproliferative effects in gastric cancer cells by targeting HoxD3