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Salivary peptide histatin 1 mediated cell adhesion: a possible role in mesenchymal-epithelial transition and in pathologies

  • Irene A. van Dijk , Enno C.I. Veerman , Eric A.J. Reits , Jan G.M. Bolscher EMAIL logo and Jan Stap EMAIL logo
Published/Copyright: September 13, 2018

Abstract

Histatins are histidine-rich peptides present in the saliva of humans and higher primates and have been implicated in the protection of the oral cavity. Histatin 1 is one of the most abundant histatins and recent reports show that it has a stimulating effect on cellular adherence, thereby suggesting a role in maintaining the quality of the epithelial barrier and stimulating mesenchymal-to-epithelial transition. Here we summarize these findings and discuss them in the context of previous reports. The recent findings also provide new insights in the physiological functions of histatin 1, which are discussed here. Furthermore, we put forward a possible role of histatin 1 in various pathologies and its potential function in clinical applications.

Acknowledgments

The authors thank Jacob Aten, Department of Medical Biology, Academic Medical Center (AMC), University of Amsterdam, The Netherlands, for proofreading of the manuscript; Daisy Picavet and Wikky Tigchelaar, also affiliated with the AMC, for help with the immunohistochemistry; and Ton Bronckers, Academic Centre for Dentistry, Amsterdam, for providing the fetal tissue samples.

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Received: 2018-05-07
Accepted: 2018-07-31
Published Online: 2018-09-13
Published in Print: 2018-11-27

©2018 Walter de Gruyter GmbH, Berlin/Boston

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