Evidence that cell surface localization of serine protease activity facilitates cleavage of the protease activated receptor CDCP1

References

Adams, M.N., Harrington, B.S., He, Y., Davies, C.M., Wallace, S.J., Chetty, N.P., Crandon, A.J., Oliveira, N.B., Shannon, C.M., Coward, J.I., et al. (2015). EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface. Oncogene 34, 1375–1383.10.1038/onc.2014.88Search in Google Scholar

Alajati, A., Guccini, I., Pinton, S., Garcia-Escudero, R., Bernasocchi, T., Sarti, M., Montani, E., Rinaldi, A., Montemurro, F., Catapano, C., et al. (2015). Interaction of CDCP1 with HER2 enhances HER2-driven tumorigenesis and promotes trastuzumab resistance in breast cancer. Cell Rep. 11, 564–576.10.1016/j.celrep.2015.03.044Search in Google Scholar

Awakura, Y., Nakamura, E., Takahashi, T., Kotani, H., Mikami, Y., Kadowaki, T., Myoumoto, A., Akiyama, H., Ito, N., Kamoto, T., et al. (2008). Microarray-based identification of CUB-domain containing protein 1 as a potential prognostic marker in conventional renal cell carcinoma. J. Cancer Res. Clin. Oncol. 134, 1363–1369.10.1007/s00432-008-0412-4Search in Google Scholar

Barre, O., Dufour, A., Eckhard, U., Kappelhoff, R., Beliveau, F., Leduc, R., and Overall, C.M. (2014). Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries. PLoS One 9, e105984.10.1371/journal.pone.0105984Search in Google Scholar

Bhatt, A.S., Erdjument-Bromage, H., Tempst, P., Craik, C.S., and Moasser, M.M. (2005). Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene 24, 5333–5343.10.1038/sj.onc.1208582Search in Google Scholar

Brown, T.A., Yang, T.M., Zaitsevskaia, T., Xia, Y., Dunn, C.A., Sigle, R.O., Knudsen, B., and Carter, W.G. (2004). Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. J. Biol. Chem. 279, 14772–14783.10.1074/jbc.M309678200Search in Google Scholar

Casar, B., He, Y., Iconomou, M., Hooper, J.D., Quigley, J.P., and Deryugina, E.I. (2012). Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. Oncogene 31, 3924–3938.10.1038/onc.2011.555Search in Google Scholar

Casar, B., Rimann, I., Kato, H., Shattil, S.J., Quigley, J.P., and Deryugina, E.I. (2014). In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling. Oncogene 33, 255–268.10.1038/onc.2012.547Search in Google Scholar

Chen, Y., Harrington, B.S., Lau, K.C., Burke, L.J., He, Y., Iconomou, M., Palmer, J.S., Meade, B., Lumley, J.W., and Hooper, J.D. (2017). Development of an enzyme-linked immunosorbent assay for detection of CDCP1 shed from the cell surface and present in colorectal cancer serum specimens. J. Pharm. Biomed. Anal. 139, 65–72.10.1016/j.jpba.2017.02.047Search in Google Scholar

Dano, K., Andreasen, P.A., Grondahl-Hansen, J., Kristensen, P., Nielsen, L.S., and Skriver, L. (1985). Plasminogen activators, tissue degradation, and cancer. Adv. Cancer Res. 44, 139–266.10.1016/S0065-230X(08)60028-7Search in Google Scholar

Dass, K., Ahmad, A., Azmi, A.S., Sarkar, S.H., and Sarkar, F.H. (2008). Evolving role of uPA/uPAR system in human cancers. Cancer Treat. Rev. 34, 122–136.10.1016/j.ctrv.2007.10.005Search in Google Scholar PubMed

Dong, Y., Harrington, B.S., Adams, M.N., Wortmann, A., Stephenson, S.A., Lisle, J., Herington, A., Hooper, J.D., and Clements, J.A. (2014). Activation of membrane-bound proteins and receptor systems: a link between tissue kallikrein and the KLK-related peptidases. Biol. Chem. 395, 977–990.10.1515/hsz-2014-0147Search in Google Scholar PubMed

Emerling, B.M., Benes, C.H., Poulogiannis, G., Bell, E.L., Courtney, K., Liu, H., Choo-Wing, R., Bellinger, G., Tsukazawa, K.S., Brown, V., et al. (2013). Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc. Natl. Acad. Sci. USA 110, 3483–3488.10.1073/pnas.1222435110Search in Google Scholar PubMed PubMed Central

Gaffney, P.J. and Heath, A.B. (1990). A collaborative study to establish a standard for high molecular weight urinary-type plasminogen activator (HMW/u-PA). Thromb. Haemost. 64, 398–401.10.1055/s-0038-1647326Search in Google Scholar

Gao, W., Chen, L., Ma, Z., Du, Z., Zhao, Z., Hu, Z., and Li, Q. (2013). Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential. Gastroenterology 145, 636–646 e635.10.1053/j.gastro.2013.05.049Search in Google Scholar PubMed

Gosalia, D.N., Salisbury, C.M., Maly, D.J., Ellman, J.A., and Diamond, S.L. (2005). Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays. Proteomics 5, 1292–1298.10.1002/pmic.200401011Search in Google Scholar PubMed

Harrington, B.S., He, Y., Davies, C.M., Wallace, S.J., Adams, M.N., Beaven, E.A., Roche, D.K., Kennedy, C., Chetty, N.P., Crandon, A.J., et al. (2016). Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer. Br. J. Cancer 114, 417–426.10.1038/bjc.2015.471Search in Google Scholar PubMed PubMed Central

He, Y., Wortmann, A., Burke, L.J., Reid, J.C., Adams, M.N., Abdul-Jabbar, I., Quigley, J.P., Leduc, R., Kirchhofer, D., and Hooper, J.D. (2010). Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCδ. J. Biol. Chem. 285, 26162–26173.10.1074/jbc.M109.096453Search in Google Scholar PubMed PubMed Central

He, Y., Harrington, B.S., and Hooper, J.D. (2016a). New crossroads for potential therapeutic intervention in cancer – intersections between CDCP1, EGFR family members and downstream signaling pathways. Oncoscience 3, 5–8.10.18632/oncoscience.286Search in Google Scholar PubMed PubMed Central

He, Y., Wu, A.C., Harrington, B.S., Davies, C.M., Wallace, S.J., Adams, M.N., Palmer, J.S., Roche, D.K., Hollier, B.G., Westbrook, T.F., et al. (2016b). Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance. Oncogene 35, 468–478.10.1038/onc.2015.101Search in Google Scholar PubMed

Hooper, J.D., Zijlstra, A., Aimes, R.T., Liang, H., Claassen, G.F., Tarin, D., Testa, J.E., and Quigley, J.P. (2003). Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene 22, 1783–1794.10.1038/sj.onc.1206220Search in Google Scholar PubMed

Ikeda, J., Oda, T., Inoue, M., Uekita, T., Sakai, R., Okumura, M., Aozasa, K., and Morii, E. (2009). Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung. Cancer Sci. 100, 429–433.10.1111/j.1349-7006.2008.01066.xSearch in Google Scholar PubMed

Lucas, J.M., Heinlein, C., Kim, T., Hernandez, S.A., Malik, M.S., True, L.D., Morrissey, C., Corey, E., Montgomery, B., Mostaghel, E., et al. (2014). The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov. 4, 1310–1325.10.1158/2159-8290.CD-13-1010Search in Google Scholar PubMed PubMed Central

Meyer, D., Sielaff, F., Hammami, M., Bottcher-Friebertshauser, E., Garten, W., and Steinmetzer, T. (2013). Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation. Biochem. J. 452, 331–343.10.1042/BJ20130101Search in Google Scholar PubMed

Razorenova, O.V., Finger, E.C., Colavitti, R., Chernikova, S.B., Boiko, A.D., Chan, C.K., Krieg, A., Bedogni, B., LaGory, E., Weissman, I.L., et al. (2011). VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKCδ-driven migration. Proc. Natl. Acad. Sci. USA 108, 1931–1936.10.1073/pnas.1011777108Search in Google Scholar PubMed PubMed Central

Reid, J.C., Matsika, A., Davies, C.M., He, Y., Broomfield, A., Bennett, N.C., Magdolen, V., Srinivasan, B., Clements, J.A., and Hooper, J.D. (2017). Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases. Am. J. Cancer Res. 7, 2257–2274.Search in Google Scholar

Tanabe, L.M. and List, K. (2017). The role of type II transmembrane serine protease-mediated signaling in cancer. FEBS J. 284, 1421–1436.10.1111/febs.13971Search in Google Scholar PubMed PubMed Central

Turdo, F., Bianchi, F., Gasparini, P., Sandri, M., Sasso, M., De Cecco, L., Forte, L., Casalini, P., Aiello, P., Sfondrini, L., et al. (2016). CDCP1 is a novel marker of the most aggressive human triple-negative breast cancers. Oncotarget 7, 69649–69665.10.18632/oncotarget.11935Search in Google Scholar PubMed PubMed Central

Uekita, T. and Sakai, R. (2011). Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis. Cancer Sci. 102, 1943–1948.10.1111/j.1349-7006.2011.02052.xSearch in Google Scholar PubMed

Varghese, R.T., Liang, Y., Guan, T., Franck, C.T., Kelly, D.F., and Sheng, Z. (2016). Survival kinase genes present prognostic significance in glioblastoma. Oncotarget 7, 20140–20151.10.18632/oncotarget.7917Search in Google Scholar PubMed PubMed Central

Wong, C.H., Baehner, F.L., Spassov, D.S., Ahuja, D., Wang, D., Hann, B., Blair, J., Shokat, K., Welm, A.L., and Moasser, M.M. (2009). Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers. Clin. Cancer Res. 15, 2311–2322.10.1158/1078-0432.CCR-08-2533Search in Google Scholar PubMed PubMed Central

Wright, H.J., Arulmoli, J., Motazedi, M., Nelson, L.J., Heinemann, F.S., Flanagan, L.A., and Razorenova, O.V. (2016). CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. Oncogene 35, 4762–4772.10.1038/onc.2016.7Search in Google Scholar PubMed PubMed Central

Yang, L., Dutta, S.M., Troyer, D.A., Lin, J.B., Lance, R.A., Nyalwidhe, J.O., Drake, R.R., and Semmes, O.J. (2015). Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. Oncotarget 22, 43743–43758.10.18632/oncotarget.6193Search in Google Scholar PubMed PubMed Central