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Modulation of oncogenic signaling networks by Kaposi’s sarcoma-associated herpesvirus

  • Jason P. Wong and Blossom Damania EMAIL logo
Published/Copyright: March 11, 2017

Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of three human malignancies: Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. To persist and replicate within host cells, KSHV encodes proteins that modulate different signaling pathways. Manipulation of cell survival and proliferative networks by KSHV can promote the development of KSHV-associated malignancies. In this review, we discuss recent updates on KSHV pathogenesis and the viral life cycle. We focus on proteins encoded by KSHV that modulate the phosphatidylinositol-4,5-bisphosphate 3 kinase and extracellular signal-regulated kinases 1/2 pathways to create an environment favorable for viral replication and the development of KSHV malignancies.

Acknowledgements

We apologize for not citing many publications due to a reference limit per journal policy. We thank the members of the Damania lab for helpful discussions. Our work is supported by public health service grants CA019014, CA096500, CA163217, and DE023946. BD is a Leukemia and Lymphoma Society Scholar, and a Burroughs Wellcome Fund Investigator in Infectious Disease. J.P.W. was supported in part by the National Institutes of Health training grant T32 AI007419.

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Received: 2017-1-2
Accepted: 2017-3-8
Published Online: 2017-3-11
Published in Print: 2017-7-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

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