Startseite Increased secretory sphingomyelinase activity in the first trimester of pregnancy in women later developing preeclampsia: a nested case-control study
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Increased secretory sphingomyelinase activity in the first trimester of pregnancy in women later developing preeclampsia: a nested case-control study

  • Víctor Rodríguez-Sureda ORCID logo EMAIL logo , Francesca Crovetto , Stefania Triunfo , Olga Sánchez , Fátima Crispi , Elisa Llurba , Eduard Gratacós , Francesc Figueras und Carmen Domínguez
Veröffentlicht/Copyright: 12. Januar 2016
Biological Chemistry
Aus der Zeitschrift Biological Chemistry Band 397 Heft 3

Abstract

The pathogenic basis of abnormal placentation and dysfunction in preeclampsia (PE) is highly complex and incompletely understood. Secretory sphyngomyelinase activity (S-ASM) was analyzed in plasma samples from 158 pregnant women developing PE and 112 healthy pregnant controls. Serum PlGF, sFlt-1, s-Endoglin and sVCAM were measured. Results showed S-ASM activity to be higher in women who later developed PE than in those with uncomplicated pregnancies (40.6% and 28.8% higher in the late- and early-onset groups, respectively). Plasma S-ASM activity correlated significantly with circulating markers of endothelial damage in the late-PE group (endoglin and sVCAM-1), with plasma cholesterol and total lipid levels. However, these significant associations were not observed in the early-PE or control groups. This work provides the first evidence of significantly elevated circulating S-ASM activity in the first trimester of pregnancy in women who go on to develop PE; thus, it may be deduced that the circulating form of ASM is biologically active in PE and could contribute to promoting endothelial dysfunction and cardiovascular programming. Plasma S-ASM measurement may have clinical relevance as a further potential biomarker contributing to the earliest identification of women at risk of developing preeclampsia.

Keywords: angiogenic factors; first-trimester of pregnancy; lipids; preeclampsia; secretory acid sphingomyelinase (S-ASM); VCAM
Corresponding author: Víctor Rodríguez-Sureda, Centre for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, E-08035 Barcelona, Spain; and Biochemistry and Molecular Biology Research Centre for Nanomedicine, Hospital Universitari Vall d’Hebron, Pg. de la Vall d’Hebron, 119-129, E-08035 Barcelona, Spain, e-mail: .

Acknowledgments

Dr. Rodríguez-Sureda is supported by the Centre for Biomedical Network Research on Rare Diseases (CIBERER) from Instituto de Salud Carlos III. The study was supported in part by grants from Fondo de Investigaciones Sanitarias (FIS PI12/00851 and FIS PI13/01449). The samples used in this Project were provided by the Hospital Clínic-IDIBAPS Biobank and Biobanc HUVH with an appropiate ethical approval. We are grateful to Miss C. O’Hara for her help in editing the English language in the original manuscript.

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Received: 2015-10-15
Accepted: 2015-12-28
Published Online: 2016-1-12
Published in Print: 2016-3-1

©2016 by De Gruyter

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https://doi.org/10.1515/hsz-2015-0266
Schlagwörter für diesen Artikel
angiogenic factors; first-trimester of pregnancy; lipids; preeclampsia; secretory acid sphingomyelinase (S-ASM); VCAM

Artikel in diesem Heft

  1. Frontmatter
  2. Guest Editorial
  3. Highlight: Perspectives of molecular neuroscience in health and disease
  4. HIGHLIGHT: CURRENT CONCE PTS OF PROTECTION AND REGE NERATION IN BRAIN DISORDERS
  5. The cytoskeleton as a drug target for neuroprotection: the case of the autism- mutated ADNP
  6. Protein aggregate formation in oligodendrocytes: tau and the cytoskeleton at the intersection of neuroprotection and neurodegeneration
  7. How to build the fastest receptor on earth
  8. Signaling pathways regulating Homer1a expression: implications for antidepressant therapy
  9. RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunction
  10. Defective actin dynamics in dendritic spines: cause or consequence of age-induced cognitive decline?
  11. Review
  12. Role of chitinase-like proteins in cancer
  13. Research Articles/Short Communications
  14. Cell Biology and Signaling
  15. Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts
  16. Chemopreventive and hepatoprotective roles of adiponectin (SULF2 inhibitor) in hepatocelluar carcinoma
  17. Molecular Medicine
  18. Increased secretory sphingomyelinase activity in the first trimester of pregnancy in women later developing preeclampsia: a nested case-control study
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