De novo ceramide synthesis is involved in acute inflammation during labor
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Paola Signorelli
, Laura Avagliano , Marta R. Reforgiato , Nadia Toppi , Josefina Casas , Gemma Fabriàs , Anna Maria Marconi , Riccardo Ghidoni und Anna Caretti
Abstract
Gestation is regulated by an inflammatory process that allows implantation and parturition. The comprehension of such inflammatory switches is important for the identification of therapeutic targets in pregnancy defects. Sphingolipids are a class of structural membrane components with important signaling functions. Among sphingolipids, ceramide is a well-known mediator of stress signals and pro-inflammatory responses. In this paper, we evaluated the association between ceramide increase and the inflammatory process of labor, comparing placentas from vaginal deliveries, including both spontaneous and induced labor, versus elective cesarean. We demonstrated that: (i) the inflammatory marker IL-6 is upregulated in labored placentas; (ii) IL-6 content inversely correlates with labor duration; (iii) ceramide content and expression of serine palmitoyl transferase (SPT, rate limiting enzyme for de novo ceramide synthesis) are increased in labored placentas; (iv) the expression of SPT directly correlates with inflammation and inversely with labor duration. These observations suggest that ceramide metabolism and signaling may be implicated in controlling important inflammatory mechanisms driving gestation: we hypothesize that ceramide can be a therapeutic target in inflammatory complications of parturition.
Acknowledgments
Financial support from the institutional grants of the University of Milan and the PhD program in ‘Molecular and Translational Medicine’ of the University of Milan, Italy, is acknowledged.
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©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Research Articles/Short Communications
- Genes and Nucleic Acids
- Acute hypothalamo-pituitary-adrenal axis response to LPS-induced endotoxemia: expression pattern of kinin type B1 and B2 receptors
- Protein Structure and Function
- Crystal structure of cleaved vaspin (serpinA12)
- Semi-purification procedures of prions from a prion-infected brain using sucrose has no influence on the nonenzymatic glycation of the disease-associated prion isoform
- Involvement of loop 5 lysine residues and the N-terminal β-hairpin of the ribotoxin hirsutellin A on its insecticidal activity
- Membranes, Lipids, Glycobiology
- De novo ceramide synthesis is involved in acute inflammation during labor
- Cell Biology and Signaling
- A role for NGF and its receptors TrKA and p75NTR in the progression of COPD
- Proteolysis
- Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion
Artikel in diesem Heft
- Frontmatter
- Research Articles/Short Communications
- Genes and Nucleic Acids
- Acute hypothalamo-pituitary-adrenal axis response to LPS-induced endotoxemia: expression pattern of kinin type B1 and B2 receptors
- Protein Structure and Function
- Crystal structure of cleaved vaspin (serpinA12)
- Semi-purification procedures of prions from a prion-infected brain using sucrose has no influence on the nonenzymatic glycation of the disease-associated prion isoform
- Involvement of loop 5 lysine residues and the N-terminal β-hairpin of the ribotoxin hirsutellin A on its insecticidal activity
- Membranes, Lipids, Glycobiology
- De novo ceramide synthesis is involved in acute inflammation during labor
- Cell Biology and Signaling
- A role for NGF and its receptors TrKA and p75NTR in the progression of COPD
- Proteolysis
- Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion