Startseite Defective actin dynamics in dendritic spines: cause or consequence of age-induced cognitive decline?
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Defective actin dynamics in dendritic spines: cause or consequence of age-induced cognitive decline?

  • Till Georg Alexander Mack , Patricia Kreis und Britta Johanna Eickholt EMAIL logo
Veröffentlicht/Copyright: 8. Oktober 2015
Biological Chemistry
Aus der Zeitschrift Biological Chemistry Band 397 Heft 3

Abstract

Ageing is a complex deteriorating process that coincides with changes in metabolism, replicative senescence, increased resistance to apoptosis, as well as progressive mitochondria dysfunction that lead to an increase production and accumulation of reactive oxygen species (ROS). Although controversy on the paradigm of the oxidative damage theory of ageing exists, persuasive studies in Caenorhabditis elegans and yeast have demonstrated that manipulation of ROS can modify the process of ageing and influences the damage of proteins, lipids and DNA. In neurons, ageing impacts on the intrinsic neuronal excitability, it decreases the size of neuronal soma and induces the loss of dendrites and dendritic spines. The actin cytoskeleton is an abundant and broadly expressed system that plays critical functions in many cellular processes ranging from cell motility to controlling cell shape and polarity. It is thus hardly surprising that the expression and the function of actin in neurons is crucial for the morphological changes that occur in the brain throughout life. We propose that alterations in actin filament dynamics in dendritic spines may be one of the key events contributing to the initial phases of ageing in the brain.

Keywords: actin binding proteins; actin cytoskeleton; ageing; age-induced cognitive decline; dendritic spines; synapse
Corresponding author: Britta Johanna Eickholt, Institute of Biochemistry and Cluster of Excellence NeuroCure, Charité – Universitätsmedizin Berlin, Charitéplatz 1, D-10115 Berlin, Germany, e-mail:
aTill Georg Alexander Mack and Patricia Kreis: These authors contributed equally to this article.

Acknowledgments

We would like to thank Pirta Hotulainen for commenting on the review.

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Received: 2015-6-2
Accepted: 2015-9-27
Published Online: 2015-10-8
Published in Print: 2016-3-1

©2016 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. Guest Editorial
  3. Highlight: Perspectives of molecular neuroscience in health and disease
  4. HIGHLIGHT: CURRENT CONCE PTS OF PROTECTION AND REGE NERATION IN BRAIN DISORDERS
  5. The cytoskeleton as a drug target for neuroprotection: the case of the autism- mutated ADNP
  6. Protein aggregate formation in oligodendrocytes: tau and the cytoskeleton at the intersection of neuroprotection and neurodegeneration
  7. How to build the fastest receptor on earth
  8. Signaling pathways regulating Homer1a expression: implications for antidepressant therapy
  9. RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunction
  10. Defective actin dynamics in dendritic spines: cause or consequence of age-induced cognitive decline?
  11. Review
  12. Role of chitinase-like proteins in cancer
  13. Research Articles/Short Communications
  14. Cell Biology and Signaling
  15. Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts
  16. Chemopreventive and hepatoprotective roles of adiponectin (SULF2 inhibitor) in hepatocelluar carcinoma
  17. Molecular Medicine
  18. Increased secretory sphingomyelinase activity in the first trimester of pregnancy in women later developing preeclampsia: a nested case-control study
https://doi.org/10.1515/hsz-2015-0185
Schlagwörter für diesen Artikel
actin binding proteins; actin cytoskeleton; ageing; age-induced cognitive decline; dendritic spines; synapse

Artikel in diesem Heft

  1. Frontmatter
  2. Guest Editorial
  3. Highlight: Perspectives of molecular neuroscience in health and disease
  4. HIGHLIGHT: CURRENT CONCE PTS OF PROTECTION AND REGE NERATION IN BRAIN DISORDERS
  5. The cytoskeleton as a drug target for neuroprotection: the case of the autism- mutated ADNP
  6. Protein aggregate formation in oligodendrocytes: tau and the cytoskeleton at the intersection of neuroprotection and neurodegeneration
  7. How to build the fastest receptor on earth
  8. Signaling pathways regulating Homer1a expression: implications for antidepressant therapy
  9. RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunction
  10. Defective actin dynamics in dendritic spines: cause or consequence of age-induced cognitive decline?
  11. Review
  12. Role of chitinase-like proteins in cancer
  13. Research Articles/Short Communications
  14. Cell Biology and Signaling
  15. Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts
  16. Chemopreventive and hepatoprotective roles of adiponectin (SULF2 inhibitor) in hepatocelluar carcinoma
  17. Molecular Medicine
  18. Increased secretory sphingomyelinase activity in the first trimester of pregnancy in women later developing preeclampsia: a nested case-control study
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