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Role of lncRNAs in prostate cancer development and progression

  • Melanie Weiss

    Melanie Weiss studied Molecular Biology at the University of Strasbourg, France and received her Master’s degree under the supervision of Dr. H. Gronemeyer (IGBMC, Illkirch, France). Since 2012, she has been conducting her PhD studies in the Division of Cancer Epigenomics and Cancer Risk Factors at the German Cancer Research Center in Heidelberg, co-supervised by Dr. Clarissa Gerhäuser and Prof. Dr. Christoph Plass. Her thesis focuses on the roles of long non coding RNAs in prostate cancer and she is supported by the Helmholtz International Graduate School.

    , Christoph Plass

    Christoph Plass, studied in Berlin and Lübeck and obtained postdoctoral training in Molecular Biology at the Roswell Park Cancer Institute (RPCI) in Buffalo, NY. He became a full Professor at the Ohio State University in 2005 and accepted the position as head of the Division Epigenomics and Cancer Risk Factors at the German Cancer Research Center in Heidelberg in October 2007. His research interest is in the analysis of global genome-wide epigenetic patterns. Focus in his studies is to decipher the molecular mechanisms leading to epigenetic chances in cancer genomes.

    and Clarissa Gerhauser

    Clarissa Gerhäuser studied Pharmacy at the University of Würzburg and obtained a PhD (summa cum laude) in Pharmaceutical Biology at the University of Munich in 1993. She has worked as a postdoc and research Assistant Professor in the area of cancer chemoprevention at The University of Illinois at Chicago from 1993 to 1996. In 1996, she joined the German Cancer Research Center (DKFZ) in Heidelberg and currently heads the group Cancer Chemoprevention and Epigenomics. Her major research interest is the investigation of molecular mechanisms associated with breast and prostate cancer, with a strong focus on epigenetic mechanisms. She has authored more than 90 research articles, reviews and book chapters and holds four patents. Also, she has co-edited a comprehensive reference book on ‘Chemoprevention of Cancer and DNA damage by dietary factors’ (Wiley Press, 2009).

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Published/Copyright: August 19, 2014

Abstract

Prostate cancer (PCa) is the second most common cause of cancer-related deaths in men. Despite advances in the characterization of genomic and epigenetic aberrations contributing to PCa, the etiology of PCa is still far from being understood. Research over the past decade demonstrated the role of long non-coding RNAs (lncRNAs) in deregulation of target genes mainly through epigenetic mechanisms. In PCa, evidence accumulated that hundreds of lncRNAs are dysregulated. Functional analyses revealed their contribution to prostate carcinogenesis by targeting relevant pathways and gene regulation mechanisms including PTEN/AKT and androgen receptor signaling as well as chromatin remodeling complexes. Here we summarize our current knowledge on the roles of lncRNAs in PCa and their potential use as biomarkers for aggressive PCa and as novel therapeutic targets.


Corresponding author: Clarissa Gerhauser, Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany, e-mail:

About the authors

Melanie Weiss

Melanie Weiss studied Molecular Biology at the University of Strasbourg, France and received her Master’s degree under the supervision of Dr. H. Gronemeyer (IGBMC, Illkirch, France). Since 2012, she has been conducting her PhD studies in the Division of Cancer Epigenomics and Cancer Risk Factors at the German Cancer Research Center in Heidelberg, co-supervised by Dr. Clarissa Gerhäuser and Prof. Dr. Christoph Plass. Her thesis focuses on the roles of long non coding RNAs in prostate cancer and she is supported by the Helmholtz International Graduate School.

Christoph Plass

Christoph Plass, studied in Berlin and Lübeck and obtained postdoctoral training in Molecular Biology at the Roswell Park Cancer Institute (RPCI) in Buffalo, NY. He became a full Professor at the Ohio State University in 2005 and accepted the position as head of the Division Epigenomics and Cancer Risk Factors at the German Cancer Research Center in Heidelberg in October 2007. His research interest is in the analysis of global genome-wide epigenetic patterns. Focus in his studies is to decipher the molecular mechanisms leading to epigenetic chances in cancer genomes.

Clarissa Gerhauser

Clarissa Gerhäuser studied Pharmacy at the University of Würzburg and obtained a PhD (summa cum laude) in Pharmaceutical Biology at the University of Munich in 1993. She has worked as a postdoc and research Assistant Professor in the area of cancer chemoprevention at The University of Illinois at Chicago from 1993 to 1996. In 1996, she joined the German Cancer Research Center (DKFZ) in Heidelberg and currently heads the group Cancer Chemoprevention and Epigenomics. Her major research interest is the investigation of molecular mechanisms associated with breast and prostate cancer, with a strong focus on epigenetic mechanisms. She has authored more than 90 research articles, reviews and book chapters and holds four patents. Also, she has co-edited a comprehensive reference book on ‘Chemoprevention of Cancer and DNA damage by dietary factors’ (Wiley Press, 2009).

Acknowledgments

This work was supported in part by the German Federal Ministry of Education and Science in the program for medical genome research (FKZ: 01KU1001A). M.W. is supported by a PhD scholarship provided by the Helmholtz International Graduate School for Cancer Research at the German Cancer Research Center.

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Received: 2014-5-26
Accepted: 2014-8-12
Published Online: 2014-8-19
Published in Print: 2014-11-1

©2014 by De Gruyter

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