Abstract
Purine-rich box1 (PU.1) is a transcription factor that not only has a key role in the development of most hematopoietic cell lineages but also in the suppression of leukemia. To exert these functions, PU.1 can cross-talk with multiple different proteins by forming complexes in order to activate or repress transcription. Among its protein partners are chromatin remodelers, DNA methyltransferases, and a number of other transcription factors with important roles in hematopoiesis. While a great deal of knowledge has been acquired about PU.1 function over the years, it was the development of novel genome-wide technologies, which boosted our understanding of how PU.1 acts on the chromatin to drive its repertoire of target genes. This review summarizes current knowledge and ideas of molecular mechanisms by which PU.1 controls hematopoiesis and suppresses leukemia.
Acknowledgments
We thank Michael Rehli (Regensburg, Germany) for valuable suggestions on the manuscript. The literature regarding PU.1 is overwhelming, and we wish to apologize to those whose work we were unable to cite. This work was supported by the Deutsche Forschungsgemeinschaft Research Unit 1336 and Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University of Münster, Germany.
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©2014 by De Gruyter
Articles in the same Issue
- Frontmatter
- Guest Editorial
- Integrating Epigenetics
- HIGHLIGHT: NEW INSIGHTS IN EPIGENETICS
- Epigenetic control of hematopoiesis: the PU.1 chromatin connection
- Role of lncRNAs in prostate cancer development and progression
- Polycomb and Trithorax group protein-mediated control of stress responses in plants
- Transcription as a force partitioning the eukaryotic genome
- The epigenetic tracks of aging
- Early epigenetic cancer decisions
- Reviews
- Functions of the neuron-specific protein ADAP1 (centaurin-α1) in neuronal differentiation and neurodegenerative diseases, with an overview of structural and biochemical properties of ADAP1
- Titin: central player of hypertrophic signaling and sarcomeric protein quality control
- Research Articles/Short Communications
- Protein Structure and Function
- Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity
Articles in the same Issue
- Frontmatter
- Guest Editorial
- Integrating Epigenetics
- HIGHLIGHT: NEW INSIGHTS IN EPIGENETICS
- Epigenetic control of hematopoiesis: the PU.1 chromatin connection
- Role of lncRNAs in prostate cancer development and progression
- Polycomb and Trithorax group protein-mediated control of stress responses in plants
- Transcription as a force partitioning the eukaryotic genome
- The epigenetic tracks of aging
- Early epigenetic cancer decisions
- Reviews
- Functions of the neuron-specific protein ADAP1 (centaurin-α1) in neuronal differentiation and neurodegenerative diseases, with an overview of structural and biochemical properties of ADAP1
- Titin: central player of hypertrophic signaling and sarcomeric protein quality control
- Research Articles/Short Communications
- Protein Structure and Function
- Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity