The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves
Abstract
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is one of the most studied nuclear receptor since its identification as a target to treat metabolic and neurological diseases. In addition to exerting anti-inflammatory and neuroprotective effects, PPAR-γ agonists, such as the insulin-sensitizing drug pioglitazone, promote the differentiation of oligodendrocytes (OLs), the myelin-forming cells of the central nervous system (CNS). In addition, PPAR-γ agonists increase OL mitochondrial respiratory chain activity and OL’s ability to respond to environmental signals with oscillatory Ca2+ waves. Both OL maturation and oscillatory Ca2+ waves are prevented by the mitochondrial inhibitor rotenone and restored by PPAR-γ agonists, suggesting that PPAR-γ promotes myelination through mechanisms involving mitochondria.
This study was supported by FISM – Fondazione Italiana Sclerosi Multipla, Grant 2011/R/15.
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©2013 by Walter de Gruyter Berlin Boston
Artikel in diesem Heft
- Masthead
- Masthead
- Guest Editorial
- Highlight: perspectives in molecular neurobiology
- HIGHLIGHT: PERSPECTIVES IN MOLECULAR NEUROBIOLOGY
- Role of the peroxisome proliferator-activated receptors (PPAR)-α, β/δ and γ triad in regulation of reactive oxygen species signaling in brain
- Molecular triggers of neuroinflammation in mouse models of demyelinating diseases
- Sox appeal – Sox10 attracts epigenetic and transcriptional regulators in myelinating glia
- MeCP2 phosphorylation in the brain: from transcription to behavior
- The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves
- G-protein-coupled designer receptors – new chemical-genetic tools for signal transduction research
- Prolonged cultivation of hippocampal neural precursor cells shifts their differentiation potential and selects for aneuploid cells
- Reviews
- Eternity and functionality – rational access to physiologically relevant cell lines
- Structural and functional insights into the Spir/formin actin nucleator complex
Artikel in diesem Heft
- Masthead
- Masthead
- Guest Editorial
- Highlight: perspectives in molecular neurobiology
- HIGHLIGHT: PERSPECTIVES IN MOLECULAR NEUROBIOLOGY
- Role of the peroxisome proliferator-activated receptors (PPAR)-α, β/δ and γ triad in regulation of reactive oxygen species signaling in brain
- Molecular triggers of neuroinflammation in mouse models of demyelinating diseases
- Sox appeal – Sox10 attracts epigenetic and transcriptional regulators in myelinating glia
- MeCP2 phosphorylation in the brain: from transcription to behavior
- The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves
- G-protein-coupled designer receptors – new chemical-genetic tools for signal transduction research
- Prolonged cultivation of hippocampal neural precursor cells shifts their differentiation potential and selects for aneuploid cells
- Reviews
- Eternity and functionality – rational access to physiologically relevant cell lines
- Structural and functional insights into the Spir/formin actin nucleator complex