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Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor
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Thomas Kryza
Published/Copyright:
February 2, 2013
Abstract
Kallikrein-12 (KLK12) may play an important role in angiogenesis modulating proangiogenic factor bioavailability and activating the kinin receptor B2 pathway. We studied whether KLK12 had an impact on angiogenesis and the activation of kinin receptor B2 results from the KLK12-dependent generation of kinins. KLK12 efficiently hydrolyzed high molecular weight kininogen, liberating a fragment containing the carboxy-terminal end of kinins. The kininogenase activity of KLK12 was poor, however, due to the cleavage resistance of the N-terminal side of the kinin sequence. A very low amount of kinins was accordingly released after in vitro incubation of high molecular weight kininogen with KLK12 and thus the proangiogenic activity of KLK12 in lung endothelial cells was not related to a kinin release.
Received: 2012-9-20
Accepted: 2012-11-3
Published Online: 2013-02-02
Published in Print: 2013-03-01
©2013 by Walter de Gruyter Berlin Boston
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Keywords for this article
angiogenesis;
kallikrein-related peptidase 12;
kininogenase;
serine protease
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Highlight: Kinin 2012 in Paris
- Highlight: Kinin 2012 in Paris
- Plasma kallikrein-kinin system and diabetic retinopathy
- Tissue kallikrein, blood pressure regulation, and hypertension: insight from genetic kallikrein deficiency
- Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output
- Interactions between BdkrB2 and p53 genes in the developing kidney
- Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist
- Role of kinin B2 receptors in opioid-induced hyperalgesia in inflammatory pain in mice
- Clinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation
- Bifunctional epitope-agonist ligands of the bradykinin B2 receptor
- Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor
- Review
- Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
- Research Articles/Short Communications
- Genes and Nucleic Acids
- A genetic variant in the promoter region of miR-34b/c is associated with a reduced risk of colorectal cancer
- Protein Structure and Function
- SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins
