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Role of kinin B2 receptors in opioid-induced hyperalgesia in inflammatory pain in mice

  • Sébastien Grastilleur , Lionel Mouledous , Jerome Bedel , Jonathan Etcheverry , Michael Bader , Jean-Pierre Girolami , Olivier Fourcade , Bernard Frances EMAIL logo and Vincent Minville
Published/Copyright: February 2, 2013
Biological Chemistry
From the journal Biological Chemistry Volume 394 Issue 3

Abstract

Postoperative pain management is a clinical challenge that can be complicated by opioid-induced hyperalgesia (OIH). Kinin receptors could mediate both the acute and chronic phases of inflammation and pain. A few recent studies suggest that dynorphin A could maintain neuropathic pain by activating the bradykinin (BK) receptor. Thus, the effect of a single administration of sufentanil (a μ-opioid receptor agonist) was investigated in a model of carrageenan-induced inflammatory pain using three strains of mice, i.e., knockout mice for one kinin receptor, B1R or B2R (B1KO, B2KO), and wild-type C57/BL6J mice (WT) treated with either a B1R (R954) or a B2R antagonist (HOE140) or a KKS inhibitor (aprotinin). Pain was assessed and compared between the different groups using two behavioral tests exploring mechanical (von Frey filaments) and thermal (Hargreaves test) sensitivity. Pretreatment with sufentanil induced a sustained increase in pain sensitivity with a delayed return to baseline values characterizing an OIH in carrageenan-injected mice only. Sufentanil-induced OIH was not observed in B2KO but persisted in B1KO and was blunted by aprotinin and the B2R antagonist only. Collectively, our data indicate that the B2R receptor and BK synthesis or availability are essential peripheral steps in the mechanism leading to OIH in a pain context.

Keywords: aprotinin; B1 receptor; B2 receptor; bradykinin receptors; icatibant; opioid-induced hyperalgesia; sufentanil
Corresponding author: Bernard Frances, Université de Toulouse, Université Paul Sabatier, 118 Route de Narbonne, F-31062 Toulouse Cedex 9, France; and Centre de Recherches sur la Cognition Animale, CNRS UMR 5169, 118 Route de Narbonne, F-31062 Toulouse Cedex 9, France
Received: 2012-10-18
Accepted: 2013-1-3
Published Online: 2013-02-02
Published in Print: 2013-03-01

©2013 by Walter de Gruyter Berlin Boston

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Guest Editorial
  4. Highlight: Kinin 2012 in Paris
  5. Highlight: Kinin 2012 in Paris
  6. Plasma kallikrein-kinin system and diabetic retinopathy
  7. Tissue kallikrein, blood pressure regulation, and hypertension: insight from genetic kallikrein deficiency
  8. Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output
  9. Interactions between BdkrB2 and p53 genes in the developing kidney
  10. Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist
  11. Role of kinin B2 receptors in opioid-induced hyperalgesia in inflammatory pain in mice
  12. Clinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation
  13. Bifunctional epitope-agonist ligands of the bradykinin B2 receptor
  14. Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor
  15. Review
  16. Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
  17. Research Articles/Short Communications
  18. Genes and Nucleic Acids
  19. A genetic variant in the promoter region of miR-34b/c is associated with a reduced risk of colorectal cancer
  20. Protein Structure and Function
  21. SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins
https://doi.org/10.1515/hsz-2012-0305
Keywords for this article
aprotinin; B1 receptor; B2 receptor; bradykinin receptors; icatibant; opioid-induced hyperalgesia; sufentanil

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Guest Editorial
  4. Highlight: Kinin 2012 in Paris
  5. Highlight: Kinin 2012 in Paris
  6. Plasma kallikrein-kinin system and diabetic retinopathy
  7. Tissue kallikrein, blood pressure regulation, and hypertension: insight from genetic kallikrein deficiency
  8. Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output
  9. Interactions between BdkrB2 and p53 genes in the developing kidney
  10. Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist
  11. Role of kinin B2 receptors in opioid-induced hyperalgesia in inflammatory pain in mice
  12. Clinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation
  13. Bifunctional epitope-agonist ligands of the bradykinin B2 receptor
  14. Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor
  15. Review
  16. Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
  17. Research Articles/Short Communications
  18. Genes and Nucleic Acids
  19. A genetic variant in the promoter region of miR-34b/c is associated with a reduced risk of colorectal cancer
  20. Protein Structure and Function
  21. SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins
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