Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output
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Xianming Zhang
Abstract
The G protein-coupled receptors (GPCRs) are the largest class of membrane proteins that play key roles in transducing extracellular signals to intracellular proteins to generate cellular responses. The kinin GPCRs, named B1 (B1R) and B2 (B2R), are responsible for mediating the biological responses to kinin peptides released from the precursor kininogens. Bradykinin (BK) or kallidin (KD) are agonists for B2Rs, whereas their carboxypeptidase (CP)-generated metabolites, des-Arg9-BK or des-Arg10-KD, are specific agonists for B1Rs. Here, we review the evidence for a critical role of membrane-bound CPM in facilitating B1R signaling by its ability to directly activate the receptor via conformational crosstalk as well as generate its specific agonist. In endothelial cells, the CPM/B1R interaction facilitates B1R-dependent high-output nitric oxide under inflammatory conditions.
©2013 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Highlight: Kinin 2012 in Paris
- Highlight: Kinin 2012 in Paris
- Plasma kallikrein-kinin system and diabetic retinopathy
- Tissue kallikrein, blood pressure regulation, and hypertension: insight from genetic kallikrein deficiency
- Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output
- Interactions between BdkrB2 and p53 genes in the developing kidney
- Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist
- Role of kinin B2 receptors in opioid-induced hyperalgesia in inflammatory pain in mice
- Clinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation
- Bifunctional epitope-agonist ligands of the bradykinin B2 receptor
- Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor
- Review
- Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
- Research Articles/Short Communications
- Genes and Nucleic Acids
- A genetic variant in the promoter region of miR-34b/c is associated with a reduced risk of colorectal cancer
- Protein Structure and Function
- SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Highlight: Kinin 2012 in Paris
- Highlight: Kinin 2012 in Paris
- Plasma kallikrein-kinin system and diabetic retinopathy
- Tissue kallikrein, blood pressure regulation, and hypertension: insight from genetic kallikrein deficiency
- Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output
- Interactions between BdkrB2 and p53 genes in the developing kidney
- Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist
- Role of kinin B2 receptors in opioid-induced hyperalgesia in inflammatory pain in mice
- Clinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation
- Bifunctional epitope-agonist ligands of the bradykinin B2 receptor
- Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor
- Review
- Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
- Research Articles/Short Communications
- Genes and Nucleic Acids
- A genetic variant in the promoter region of miR-34b/c is associated with a reduced risk of colorectal cancer
- Protein Structure and Function
- SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins
