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Beyond anemia: hepcidin, monocytes and inflammation
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Xiaolan Zhang
Published/Copyright:
January 8, 2013
Abstract
Hepcidin is an iron regulatory protein mainly synthesized by the liver. Hepatocyte production of hepcidin is responsible for serum hepcidin, is responsive to body iron stores, and is critical for maintaining iron homeostasis. Monocytes and macrophages also express hepcidin, and in contrast to the liver, hepcidin expression is primarily regulated by inflammatory mediators and infectious agents. Monocyte and macrophage hepcidin is likely to be more important on a local rather than systemic level, contributes to host defense and may modulate inflammatory processes. This review summarizes recent findings and hypotheses on the relationship of hepcidin to the mononuclear phagocyte system.
Received: 2012-5-30
Accepted: 2012-9-27
Published Online: 2013-01-08
Published in Print: 2013-02-01
©2013 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Highlight: The physiology and dynamics of cellular microcompartments
- Highlight: The Physiology and Dynamics of Cellular Microcompartments
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- Microcompartments in the Drosophila heart and the mammalian brain: general features and common principles
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- Beyond anemia: hepcidin, monocytes and inflammation
- Melanoma resistance to photodynamic therapy: new insights
- The biosynthesis of caprazamycins and related liponucleoside antibiotics: new insights
- cCMP, cUMP, cTMP, cIMP and cXMP as possible second messengers: Development of a hypothesis based on studies with soluble guanylyl cyclase α1β1
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- Protein Structure and Function
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- Proteolysis
- ADAMTS: Novel proteases expressed by activated mast cells
- The proinflammatory cytokines interleukin-1α and tumor necrosis factor α promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes
