Genetic polymorphisms in the human tissue kallikrein (KLK) locus and their implication in various malignant and non-malignant diseases
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Jyotsna Batra
Dr Jyotsna Batra is an NHMRC Peter Doherty Fellow at Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, QUT. She has studied Biochemistry towards a Master’s degree at the Kurukshetra University, India in 2002. Jyotsna finished her PhD on Human genetics in 2008 from the Institute of Genomics and Integrative Biology, India, working on the complexity of the heredity allergic disorders. The focus of her current postdoctoral fellowship is to identify the molecular consequences of prostate cancer risk-associated single nucleotide polymorphisms (SNPs) already identified by GWAS and/or by fine mapping of the
KLK3 gene, and to investigate novel Kallikrein gene SNPs extracted from Nextgen sequencing for an association with prostate cancer risk and/or prognostic features.
,
Tracy O’Mara
Tracy O’Mara graduated with a Bachelor of Applied Science (Life Sciences) with first class honours from the Queensland University of Technology (QUT) in 2005. From 2006–2008 she worked as a Research Assistant for Dr Mary-Anne Kedda from the School of Public Health and Institute of Health and Biomedical Innovation, QUT. Tracy began her PhD investigating the role of single nucleotide polymorphisms on endometrial cancer risk and aggressiveness in 2008 under the supervision of A/Prof Amanda Spurdle from the Queensland Institute of Medical Research and Prof Judith Clements from the Institute of Biomedical Innovation, QUT.
Radhika Patnala completed her B.Tech Biotechnology from GITAM University, India in 2009 and graduated with Masters of Biotechnology (Honours) from the Australian National University, Canberra in 2011, under supervision of Dr Danny Rangasamy, John Curtin School of Medical Research. She then worked as a part time Research Assistant at Queensland University of Technology with Dr Jyotsna Batra. She will be pursuing doctoral research in the field of Neuroscience from August 2012 under A/Prof S Thameem Dheen at the Yong Loo Lin School of Medicine, National University of Singapore.
Felicity Lose completed her PhD from Queensland Institute of Medical Research in 2007 in cancer genetics. Since then, she have been involved in prostate cancer research, firstly as Project Co-ordinator for two large control recruitment projects (over 1200 controls recruited total), and now involved in genotyping and analysis of our large prostate cancer case and male control sample sets for the Kallikrein genes.
BAppSc, RMIT, 1982; MAppSc, RMIT, 1983; PhD, Monash University, 1989.
Professor Judith Clements is an NHMRC Principal Research Fellow, Scientific Director of the Australian Prostate Cancer Research Centre-Queensland and leads the Cancer Program at the Institute of Health and Biomedical Innovation, Queensland University of Technology. Her research focuses on mechanistic and translational studies of the role of PSA and the related kallikrein serine peptidases in prostate cancer.
©2012 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Highlight: 29th Winter School on Proteinases and Their Inhibitors
- Highlight: 29th Winter School on Proteinases and their Inhibitors
- Genetic polymorphisms in the human tissue kallikrein (KLK) locus and their implication in various malignant and non-malignant diseases
- Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon
- Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins
- Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines
- Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells
- Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes
- IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells
- Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-β1 activation and reduces regulatory ID gene expression
- Gingipain aminopeptidase activities in Porphyromonas gingivalis
- CLIPPER: an add-on to the Trans-Proteomic Pipeline for the automated analysis of TAILS N-terminomics data
- Review
- Integration of cellular bioenergetics with mitochondrial quality control and autophagy
- Research Articles/Short Communications
- Genes and Nucleic Acids
- A conformational switch is responsible for the reversal of the 6S RNA-dependent RNA polymerase inhibition in Escherichia coli
- Protein Structure and Function
- Molecular determinants of human dipeptidyl peptidase III sensitivity to thiol modifying reagents
- Modular structure of HEL protein from Arabidopsis reveals new potential functions for PR-4 proteins
- Proteolysis
- Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides
- Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Highlight: 29th Winter School on Proteinases and Their Inhibitors
- Highlight: 29th Winter School on Proteinases and their Inhibitors
- Genetic polymorphisms in the human tissue kallikrein (KLK) locus and their implication in various malignant and non-malignant diseases
- Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon
- Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins
- Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines
- Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells
- Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes
- IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells
- Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-β1 activation and reduces regulatory ID gene expression
- Gingipain aminopeptidase activities in Porphyromonas gingivalis
- CLIPPER: an add-on to the Trans-Proteomic Pipeline for the automated analysis of TAILS N-terminomics data
- Review
- Integration of cellular bioenergetics with mitochondrial quality control and autophagy
- Research Articles/Short Communications
- Genes and Nucleic Acids
- A conformational switch is responsible for the reversal of the 6S RNA-dependent RNA polymerase inhibition in Escherichia coli
- Protein Structure and Function
- Molecular determinants of human dipeptidyl peptidase III sensitivity to thiol modifying reagents
- Modular structure of HEL protein from Arabidopsis reveals new potential functions for PR-4 proteins
- Proteolysis
- Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides
- Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis
