Mature cystic ovarian teratoma with squamous cell carcinoma transformation: a case report and literature review

Mahdi Abdoli Shadbad; Roghaiyeh Derogar; Ali Akbar Shekarchi; Farideh Akbari; Mehri Jafari Shobeiri

doi:10.1515/hmbci-2023-0001

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Article

Mature cystic ovarian teratoma with squamous cell carcinoma transformation: a case report and literature review

Mahdi Abdoli Shadbad , Roghaiyeh Derogar , Ali Akbar Shekarchi , Farideh Akbari and Mehri Jafari Shobeiri

Published/Copyright: January 30, 2024

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From the journal Hormone Molecular Biology and Clinical Investigation Volume 45 Issue 1

Abstract

Objectives

Cancerous transformation in mature cystic ovarian teratoma is rare. Herein, we reported a case of squamous cell carcinoma transformation in mature cystic ovarian teratoma and performed an in-depth literature review to highlight the risk factors, prognosis, and suggested treatment for these patients.

Case presentation

We report a 66-years old postmenopausal woman diagnosed with a 120×90 (mm) mass at the left adnexa compatible with mature cystic ovarian teratoma. Following resection, the histopathological investigations showed malignant transformation in her mature cystic ovarian teratoma, and the immunohistochemistry for cytokeratin (CK) 5/6 and tumor protein 63 (P63) indicated squamous cell carcinoma transformation. She has been observed for her stage IA tumor and has been cancer-free for 6 months.

Conclusions

Although malignant transformation in mature cystic ovarian teratoma is rare, it should be suspected if certain risk factors, e.g., elderly and high tumor size, exist. Stage IA patients’ prognosis is favorable, and chemotherapy is not recommended.

Keywords: neoplasms; ovarian teratoma; squamous cell carcinoma; case report; ovary

Corresponding authors: Mahdi Abdoli Shadbad, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran, E-mail: abdoli.med99@gmail.com; and Mehri Jafari Shobeiri, Fellowship in Gynecologic Oncology, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, E-mail: jafarimehri@yahoo.com

Mahdi Abdoli Shadbad and Roghaiyeh Derogar contributed equally to this work.

Acknowledgments

We appreciate all of the healthcare providers of Alzahra Hospital, a teaching and tertiary referral hospital affiliated with Tabriz University of Medical Sciences, Tabriz, Iran. The research protocol was approved and supported by Student Research Committee, Tabriz University of Medical Sciences.

Research ethics: This study was approved by the Ethics Committee of Tabriz University of Medical Sciences. Also, the study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).
Informed consent: Informed consent was obtained from the individual included in this study, or their legal guardians or wards.
Author contributions: M.A.S. wrote the initial draft of the manuscript. R.D. searched the databases, aided in data collection, performed the literature review, and aided in surgery and case detection. F.A. (attending medical oncologist) and A.A.S. (attending pathologist) critically revise the manuscript and provided the related information. M.J.S. supervised the study and surgery and edited the manuscript (attending gynecologic oncologist). The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: The authors state no conflict of interest.
Research funding: None declared.
Data availability: Not applicable.

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Received: 2023-01-05

Accepted: 2024-01-03

Published Online: 2024-01-30

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Articles in the same Issue

https://doi.org/10.1515/hmbci-2023-0001

Keywords for this article

neoplasms; ovarian teratoma; squamous cell carcinoma; case report; ovary