Dose exposure of Bisphenol- A on female Wistar rats fertility
-
Seema Srivastava
und
Nupoor Dhagga
Abstract
Background
2, 2-Bis (4-hydroxyphenyl propane [bisphenol A (BPA)] is one of the major environmental pollutants and has the adverse effects on human health. BPA mimics the structure of estrogen and binds to estrogen receptors and alters the secretion of the hormone. It is ingested in humans through the regular use of plastic containers, bottles and food cans.
Materials and methods
Female Wistar rats were exposed orally to 5, 50, 300, 600 and 800 mg BPA/kg body weight (bd. wt.)/week mixed in olive oil and administered every 168 h for 3 months continuing through the mating, gestation and lactation and its effects on fertility, reproductive organ weight and hormones [LH (luteinizing hormone), FSH (follicle stimulating hormone), estradiol (E2), progesterone (PROG) and PRL (prolactin)] were evaluated.
Results
The findings revealed that females exposed to BPA exhibited a decrease in female fertility rate and weight of reproductive organs (ovary and uterus) with significant decreased levels of LH, FSH, E2, PROG and PRL in the non-pregnancy phase whereas in cesarean and post-term females, no significance difference was found in fertility rate, reproductive organ weight and hormonal levels.
Conclusions
These data indicate an increased sensitivity to BPA needs careful evaluation of the current levels of exposure.
Acknowledgment
The authors express their sincere gratitude to the Head of the Department of Zoology, University of Rajasthan, Jaipur, Rajasthan for providing necessary research facilities for the successful completion of this study.
Author Statement
Research funding: No funding declared.
Conflict of interest: There are no conflicts of interest.
Informed consent: Not applicable.
Ethical approval: The experimental protocol was approved by the Institutional Animal Ethical Committee (IAEC), Department of Zoology, University of Rajasthan, Jaipur, India.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Original Articles
- Characterizing the differential physiological effects of adipocytokines visfatin and resistin in liver cancer cells
- Effects of different loading exercises on apelin levels and physical and hematologic parameters of swimmers
- Dose exposure of Bisphenol- A on female Wistar rats fertility
- Effect of moderate and high-intensity endurance and resistance training on serum concentrations of MSTN and IGF-1 in old male Wistar rats
Artikel in diesem Heft
- Original Articles
- Characterizing the differential physiological effects of adipocytokines visfatin and resistin in liver cancer cells
- Effects of different loading exercises on apelin levels and physical and hematologic parameters of swimmers
- Dose exposure of Bisphenol- A on female Wistar rats fertility
- Effect of moderate and high-intensity endurance and resistance training on serum concentrations of MSTN and IGF-1 in old male Wistar rats
